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991.
Trajectories of impairment in amyotrophic lateral sclerosis: Insights from the Pooled Resource Open‐Access ALS Clinical Trials cohort
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Nimish J. Thakore MD DM Brittany R. Lapin PhD MPH Erik P. Pioro MD PhD Pooled Resource Open‐Access ALS Clinical Trials Consortium 《Muscle & nerve》2018,57(6):937-945
Introduction: Rate of decline of the Amyotrophic Lateral Sclerosis Functional Rating Scale‐Revised (ALSFRS‐R) score is a common outcome measure and a powerful predictor of mortality in ALS. Methods: Observed rate of decline (postslope) of ALSFRS‐R, its linearity, and its relationship to decline at first visit (preslope) were examined in the Pooled Resource Open‐Access ALS Clinical Trials cohort by using longitudinal mixed effects models. Results: Mean ALSFRS‐R postslope in 3,367 patients was ?0.99 points/month. Preslope and postslope were correlated and had powerful effects on survival. ALSFRS‐R trajectories were slightly accelerated overall, but slope and direction/degree of curvature varied. Subscore decline was sequential by site of onset. Respiratory subscore decline was the least steep. Discussion: Variable curvilinearity of ALSFRS‐R trajectories confounds interpretation in clinical studies that assume linear decline. Subscore trajectories recapitulate phenotypic diversity and topographical progression of ALS. ALSFRS‐R is better used as a multidimensional measure. Muscle Nerve 57 : 937–945, 2018 相似文献
992.
Prevalence and predictors of peripheral neuropathy in nondiabetic children with chronic kidney disease
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Sangeetha Yoganathan DM Arvind Bagga MD Sheffali Gulati MD G. S. Toteja PhD Pankaj Hari MD Aditi Sinha MD Ravindra Mohan Pandey MD Mohammad Irshad MD 《Muscle & nerve》2018,57(5):792-798
Introduction: This study sought to determine the prevalence and predictors of peripheral neuropathy in nondiabetic children with chronic kidney disease (CKD). Methods: Fifty‐one consecutive normally nourished children, 3–18 years of age, with CKD stages IV and V of nondiabetic etiology were enrolled from May to December 2012. Nerve conduction studies were performed in 50 children. Blood samples were analyzed for the biochemical parameters, trace elements, and micronutrients. Results: The prevalence of peripheral neuropathy in our cohort was 52% (95% confidence interval 37.65, 66.34). The majority (80.8%) of the children had axonal neuropathy, and 11.5% had demyelinating neuropathy. Isolated motor neuropathy was identified in 92.3% of the children, and sensorimotor neuropathy was identified in 7.6%. The significant risk factors associated with peripheral neuropathy were older age, low serum copper, and dialysis therapy. Discussion: Electrodiagnostic studies should be performed in children with CKD to assess for peripheral neuropathy for the purpose of optimizing medical care. Muscle Nerve 57 : 792–798, 2018 相似文献
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Amy E. Vincent PhD Hannah S. Rosa PhD Kamil Pabis MRes Conor Lawless PhD Chun Chen MBBS MRes Anne Grünewald PhD Karolina A. Rygiel PhD Mariana C. Rocha PhD Amy K. Reeve PhD Gavin Falkous MSc Valentina Perissi PhD Kathryn White PhD Tracey Davey Basil J. Petrof MD FRCP Avan A. Sayer PhD FRCP Cyrus Cooper DM FRCP David Deehan MD FRCS Robert W. Taylor PhD FRCPath Doug M. Turnbull PhD FRCP Martin Picard PhD 《Annals of neurology》2018,84(2):289-301
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Failed Attempt With Paired Associative Stimulation to Separate Functional and Organic Dystonia
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