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Filippo Spreafico Michele Murelli Brian W. Timmons Maura Massimino Ronald Barr 《Pediatric blood & cancer》2019,66(8)
The burden of morbidities affecting cardiovascular and musculoskeletal systems, metabolism, and psychosocial health in young patients with cancer is high. It is alarming that patients and survivors of childhood cancer are less physically active than their healthy peers, since exercise may improve many of these conditions significantly and is associated with reduction in all‐cause mortality in the general population. Systematic integration of exercise programing into cancer care remains an exception, above all in children. Pediatric oncologists may contribute to a culture shift towards educating patients and stakeholders on the benefit of exercise and sports for children and adolescents with cancer. 相似文献
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Miriş Dikmen Yusuf Öztürk Gianni Sagratini Massimo Ricciutelli Sauro Vittori Filippo Maggi 《Phytotherapy research : PTR》2011,25(2):208-214
For centuries, Hypericum perforatum has been used in folk medicine to treat wounds. In the present study, the wound healing activities of extracts of H. perforatum ssp. perforatum (HPP) and H. perforatum ssp. veronense (HPV) were evaluated by comparing with a titrated extract of Centella asiatica (TECA) on NIH3T3 fibroblasts. The cells were incubated with the extracts. Using microscopical methods by staining cells, mitotic ability, morphological changes and collagen production in the fibroblasts were evaluated as parameters to approach possible wound repair mechanism(s). The wound healing activity caused an increase in the percentage of polygonal fibroblasts and in collagen granule numbers in fibroblasts of HPP and HPV. At 1 µg/mL, HPP caused a greater increase in mitotic cell numbers than HPV. The most increases in polygonal cell numbers were observed with HPV at 1 and 10 µg/mL. The number of collagen granules was increased with 1 µg/mL HPV being higher than HPP. As an indication of cytotoxic effects, round cells in response to HPV and HPP extracts, were found to be increased in concentrations higher than 10–50 µg/mL. The results indicated that the two subspecies of H. perforatum have different wound healing profiles as a result of the fibroblast migration and stimulation of collagen synthesis. Copyright © 2010 John Wiley & Sons, Ltd. 相似文献
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Barbara Tomasino Eleonora Maggioni Carolina Bonivento Maria Nobile Serena D'Agostini Filippo Arrigoni Franco Fabbro Paolo Brambilla 《Human brain mapping》2022,43(13):4116
Mental imagery is part of people''s own internal processing and plays an important role in everyday life, cognition and pathology. The neural network supporting mental imagery is bottom‐up modulated by the imagery content. Here, we examined the complex associations of gender and age with the neural mechanisms underlying emotion imagery. We assessed the brain circuits involved in emotion mental imagery (vs. action imagery), controlled by a letter detection task on the same stimuli, chosen to ensure attention to the stimuli and to discourage imagery, in 91 men and women aged 14–65 years using fMRI. In women, compared with men, emotion imagery significantly increased activation within the right putamen, which is involved in emotional processing. Increasing age, significantly decreased mental imagery‐related activation in the left insula and cingulate cortex, areas involved in awareness of ones'' internal states, and it significantly decreased emotion verbs‐related activation in the left putamen, which is part of the limbic system. This finding suggests a top‐down mechanism by which gender and age, in interaction with bottom‐up effect of type of stimulus, or directly, can modulate the brain mechanisms underlying mental imagery. 相似文献
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Palaia I Pernice M Graziano M Bellati F Panici PB 《American journal of obstetrics and gynecology》2007,197(4):e5-e6
Management of cervicocarcinoma during pregnancy is influenced by gestational age, stage of disease, and patient's desire to maintain her pregnancy. We report a case of a pregnant patient with locally advanced cervicocarcinoma successfully treated by neoadjuvant chemotherapy, followed by caesarean section and radical surgery. 相似文献
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Benedetti Panici P Manci N Bellati F Di Donato V Marchetti C Calcagno M Morano G Servodio C Muzii L Angioli R 《Journal of minimally invasive gynecology》2007,14(3):348-351
The Bartholin's gland cyst is a condition that occurs in approximately 2% of women, most of whom are of reproductive age. Although benign, it is associated with significant patient discomfort. Definitive treatment involves the surgical removal of the entire cyst. The objective of this study was to describe an alternative conservative surgical technique with CO(2) laser adopted in our institution and to evaluate the feasibility, complication rate, and results obtained with this technique in an office setting. Our study showed that CO(2) laser treatment of the Bartholin's gland cyst can be carried out safely in an outpatient setting, with minimum patient discomfort and high long-term cure rates. 相似文献
60.
Gennaro Daniele Clorinda Schettino Laura Arenare Domenico Bilancia Fabio Farinati Piera Federico Stefano Tamberi Gino Crivellari Sandro Barni Raffaella Tortora Francesco Izzo Antonio Frassoldati Luigi Cavanna Claudia Mucciarini Luigi Bolondi Angelo Dinota Filippo Pelizzaro Maria Carmela Piccirillo Piera Gargiulo Massimo Di Maio Ciro Gallo Francesco Perrone Bruno Daniele 《肝癌研究(英文版)》2021,7(7):52-65
Aim: Only patients with good liver function {[Child-Pugh (CP)] A class} were eligible for trials testing sorafenib as first-line treatment of hepatocellular car... 相似文献