全文获取类型
收费全文 | 418篇 |
免费 | 22篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 74篇 |
妇产科学 | 6篇 |
基础医学 | 26篇 |
口腔科学 | 105篇 |
临床医学 | 15篇 |
内科学 | 88篇 |
皮肤病学 | 2篇 |
神经病学 | 14篇 |
特种医学 | 6篇 |
外科学 | 39篇 |
综合类 | 2篇 |
预防医学 | 7篇 |
眼科学 | 16篇 |
药学 | 26篇 |
肿瘤学 | 14篇 |
出版年
2023年 | 3篇 |
2022年 | 8篇 |
2021年 | 9篇 |
2020年 | 13篇 |
2019年 | 12篇 |
2018年 | 18篇 |
2017年 | 12篇 |
2016年 | 14篇 |
2015年 | 17篇 |
2014年 | 23篇 |
2013年 | 18篇 |
2012年 | 27篇 |
2011年 | 37篇 |
2010年 | 17篇 |
2009年 | 17篇 |
2008年 | 20篇 |
2007年 | 35篇 |
2006年 | 31篇 |
2005年 | 25篇 |
2004年 | 20篇 |
2003年 | 9篇 |
2002年 | 12篇 |
2001年 | 10篇 |
2000年 | 10篇 |
1999年 | 5篇 |
1998年 | 1篇 |
1997年 | 1篇 |
1996年 | 1篇 |
1995年 | 4篇 |
1994年 | 2篇 |
1993年 | 4篇 |
1992年 | 1篇 |
1990年 | 3篇 |
1989年 | 2篇 |
排序方式: 共有441条查询结果,搜索用时 31 毫秒
31.
Polyostotic monosystemic calvarial and spinal langerhans' cell histiocytosis treated by surgery and chemotherapy 总被引:6,自引:0,他引:6
There are several treatment modalities for Langerhans' cell histiocytosis (LCH) of bone, formerly usually referred to as eosinophilic granuloma, including surgery, radiotherapy and chemotherapy. In spinal lesions, surgery is not recommended generally, because of the potential for reconstitution of vertebral height. We report a case of multifocal monosystemic LCH treated by surgery and chemotherapy for calvarial and spinal lesions. A 7-year-old boy was initially operated for an occipital monostotic LCH of bone. Then, he was treated by surgery for cervical and thoracic lesions, and by chemotherapy with vinblastine. The patient had no complaints at the 24-month follow-up. Although surgery is not recommended for spinal lesions in children with LCH of bone, short segmental fusion and internal fixation may be a suitable choice for selected cases, especially in children who are not likely to comply with activity restrictions and in those who it is difficult to follow up. The treatment must be planned according to the characteristics of the patient. 相似文献
32.
33.
Bedia Ko?yi?it Kaymak?io?lu Sevim Rollas Eylem K?rce?ez Feyza Aricio?lu 《European journal of pharmaceutical sciences》2005,26(1):97-103
Several thiourea and urea derivatives were prepared by the reaction of 4-aminopyrazoles with substituted isothiocyanates or isocyanates. The novel compounds were tested anticonvulsant activity using by pentylenetetrazole-induced seizure (PTZ) and maximal electroshock seizure (MES) tests. Among the tested compounds, thiourea derivatives of 4b were afforded 90 and 100% protection in PTZ and MES tests at 50mg/kg, respectively. Urea derivatives of 5a and 5b were afforded 82 and 100% protection both at 25 and 50mg/kg. Also synthesized compounds were screened for antituberculosis activity against Mycobacterium tuberculosis H37Rv at 6.25 microg/mL concentration but they were not found active at these concentration. In addition, some selected compounds were evaluated for in vitro anti-HIV activity and they were all negative. 相似文献
34.
35.
F Ba F Darendeliler Petorak B Sadikolu A Bilir R Bundak N Saka & H Günöz 《Journal of paediatrics and child health》1999,35(4):401-405
Progressive diaphyseal dysplasia (PDD), a rare disorder of bones, in recent years has been accepted as a systemic disease within the spectrum of connective tissue disorders associated with immunological abnormalities. Steroids have been used in the treatment of PDD with variable success. In this report PDD is described in a 5-year-old boy who presented with leg pain, fatigue, headache and anorexia with an onset in infancy. Physical examination revealed a waddling gait, thorax deformity and thickening in the upper extremities. The diagnosis was made by radiologic demonstration of cortical thickening and a narrowed medullary cavity of the long bones of extremities. Bone scintigraphy showed areas of increased osteoblastic activity in the diaphyseal part of the long bones of extremities and the skull. Electron microscopic examination revealed myopathic and vascular changes. Serum immunoglobulin A, G and M levels were elevated and CD4 positive T cell numbers were low. Deflazacort, a steroid with a similar anti-inflammatory effect to prednisolone but with fewer adverse effects, was started in a dose of 1.2 mg/kg/day. Deflazacort treatment resulted in clinical and radiological improvement within 12 months with no side effects. In conclusion, steroids may be recommended as an effective method of treatment in PDD and deflazacort may be a safe alternative steroid. 相似文献
36.
Eralp L Ozkan K Kocaoglu M Aktas S Zihni M Türker M Ozkan FU 《Advances in therapy》2007,24(2):326-332
Investigators in the present study explored the effects of hyperbaric oxygen (HBO) therapy on distraction osteogenesis in
a rabbit limb-lengthening model. HBO treatment was provided to participants in a small animal pressure chamber once a day
during the latent period of distraction osteogenesis at 2.5 absolute atmospheres of pressure. Bone mineral density measurements
were obtained through torsional testing. The control group received no HBO treatment. Animals were killed 8 wk postoperatively
for biomechanical testing. There was a statistically significant increase in bone mineral density in the HBO group compared
with that in the non-HBO group, but no statistically significant differences were observed between biomechanical parameters
of the 2 groups. The investigators suggest that these results must be further studied through histologic examination to determine
the stepwise effects of HBO during and after collagen synthesis. 相似文献
37.
Ustuner Z Basaran M Dizdar Y Agaoglu FY Bilgic B Sakar B Basaran GA Darendeliler E Ozger H Onat H Bavbek S 《The Tohoku journal of experimental medicine》2007,213(3):221-229
Rhabdomyosarcoma (RMS) is rare disease in adults (age >or= 16 years). The data from randomized prospective trials are scarce; the clinical outcome of these patients seems poor with the currently available treatment strategies. In this study, we report a single institution's experience in the treatment of adult RMS. We reviewed the medical records of patients with RMS who were >or= 16 years and have been treated in our institution between 1988 and 2003 retrospectively. We analyzed the survival outcome of these patients and the prognostic impact of clinical/pathological factors on their survival. In total, 23 patients with RMS were identified. Median age was 26 years (range, 16-72 years). Majority of patients were male (n: 17, 73.9%), and had large tumors (>or= 5 cm, n: 13, 56.5%), localized disease (N0, M0, n: 12, 52.2%), and embryonal histology (n: 10, 43.5%). Median overall survival was 31.3 months, and the 3-year progression-free survival and overall survival rates were 19.9% and 34.94%, respectively. Patients with smaller tumors (< 5 cm) (p < 0.04), local disease (p < 0.01), and normal lactic dehydrogenase (LDH) level (p < 0.01) at the time of diagnosis were found to have better survival outcome. The tumor size, serum LDH level, and metastatic disease at the time of diagnosis are potential predictors of outcome in patients with adult RMS. Adult RMS is an aggressive disease with poor survival despite treatment. The data from prospective, randomized multicenter trials are necessary in order to improve the clinical outcome of adult RMS patients. 相似文献
38.
39.
40.
Aycan Z Cetinkaya E Darendeliler F Vidinlisan S Bas F Bideci A Demirel F Darcan S Buyukgebiz A Yildiz M Berberoglu M Bundak R 《Clinical endocrinology》2008,68(5):769-772
Background Patients with Turner syndrome (TS) are treated with GH to increase adult height. Although it is well established that GH promotes longitudinal bone growth, the effects of GH treatment on bone density are less clear. Objective To determine how GH treatment affects trabecular bone mineral density (BMD) in girls with TS at prepubertal ages in a prospective multicentre study. Patients and method Twenty‐two patients with TS in the prepubertal period with a mean age of 9·8 ± 2·5 (range 3·6–12·8) years were included in the study. All girls with TS underwent measurement of areal BMD using dual‐energy X‐ray absorptiometry (DXA) to obtain pretreatment anteroposterior (AP) lumbar spine values at L1–L4. Patients received GH (Genotropin) subcutaneously for 1 year at a dose of 0·05 mg/kg/day. Height and weight were measured at 3‐monthly intervals. The AP lumbar spine areal BMD was remeasured using the same technique after 1 year of treatment. Lumbar spine BMD Z‐scores and volumetric BMD (vBMD) Z‐scores were calculated using national standards. Results The height SDS of our cases showed a significant increase with GH therapy. The pretreatment lumbar spine (L1–L4) BMD Z‐score was –1·2 ± 1·2 SD and the vBMD Z‐score was –0·8 ± 1·6 SD. There were no significant changes in these values after 1 year of GH treatment. Prepubertal TS girls more than 11 years of age had lower vBMD Z‐scores (–1·7 ± 1·7 SD) than the girls aged less than 11 (–0·1 ± 1·0 SD) (P < 0·05) at the onset of therapy. No significant changes were observed in these values after 1 year of GH therapy. Conclusions Osteopaenia becomes apparent in prepubertal TS patients as they reach pubertal age. BMD evaluation may be necessary in these prepubertal TS girls at diagnosis. Short‐term GH therapy in these TS patients does not have a significant effect on bone density when measured at a site with a predominance of trabecular bone. 相似文献