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131.
Angelo Nascimbene Courtney McAlister Daniel Yo Stanislava Matejin Mateja Jezovnik Igor D. Gregoric Biswajit Kar 《Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital》2022,49(5)
The transcatheter aortic valve replacement procedure is used in patients with aortic stenosis. Transcatheter aortic valve replacement devices are quite versatile; thus, they are increasingly being used for nonaortic applications, such as tricuspid valve-in-valve implantation. This case series describes a transcatheter aortic valve replacement procedure in 4 patients with anatomic challenges (eg, aortic tortuosity, high valvular calcium burden, highly calcified bicuspid valve, low coronary artery takeoff, left main coronary artery occlusion, and large aortic annulus) and a fifth patient who had a failed tricuspid bioprosthesis and underwent a tricuspid valve-in-valve implantation with the Edwards SAPIEN 3 transcatheter heart valve (Edwards Lifesciences). All procedures required adjustments to the standard protocol, and each procedure was successful. The critical, technical adjustments in the deployment technique and preprocedural planning of the procedures are detailed to provide a road map for other cardiologists who encounter similar challenges. 相似文献
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Zuyao Y. Shan Sara J. Mateja Wilburn E. Reddick John O. Glass Barry L. Shulkin 《Journal of digital imaging》2011,24(3):485-493
The purpose of this study is to evaluate the accuracy of registration positron emission tomography (PET) head images to the
MRI-based brain atlas. The [18F]fluoro-2-deoxyglucose PET images were normalized to the MRI-based brain atlas using nine registration algorithms including
objective functions of ratio image uniformity (RIU), normalized mutual information (NMI), and normalized cross correlation
(CC) and transformation models of rigid-body, linear, affine, and nonlinear transformations. The accuracy of normalization
was evaluated by visual inspection and quantified by the gray matter (GM) concordance between normalized PET images and the
brain atlas. The linear and affine registration based on the RIU provided the best GM concordance (average similarity index
of 0.71 for both). We also observed that the GM concordances of linear and affine registration were higher than those of the
rigid and nonlinear registration among the methods evaluated. 相似文献
136.
Dyslipidemia, statins, and venous thromboembolism 总被引:1,自引:0,他引:1
Venous thromboembolism (VTE) is one of the most frequent and serious vascular diseases. Although the major risk factors of VTE are well recognized, the pathology often develops in subjects without any obvious precipitating factor. Recent evidence suggests a link between arterial and venous thrombosis, particularly in patients with idiopathic venous thrombosis. Therefore, similar or identical risk factors may play a role in the development of both diseases. A positive association between classical risk factors of atherosclerosis, including dyslipidemia, and VTE has been reported. Recent studies demonstrated an association between hypercholesterolemia and objectively verified VTE. Circulating lipids have been shown to have both prothrombotic- and endothelium-deteriorating properties. Studies suggested a greater generation of thrombin, endothelial dysfunction, and higher platelet activity in hyperlipidemic blood. By impeding these mechanisms, statins may protect against VTE. Observational, controlled studies and two meta-analyses showed that statins significantly reduced VTE risk, most likely in a process independent from cholesterol lowering, through mechanisms related to the pleiotropic effects of these drugs. Currently, it is unknown whether VTE prevention is a class-effect of statins, or if statins differ in their antithrombotic efficacy, and it is also unknown if statin benefit is dose-dependent. However, there are also opposite findings about the efficacy of statins in prevention of VTE. Therefore, the use of statins for prophylaxis of VTE cannot be generally recommended at this stage. Further studies are needed to identify those patients who could eventually benefit maximally from treatment with statins for prevention of VTE. 相似文献
137.
Intermediate filaments attenuate stimulation‐dependent mobility of endosomes/lysosomes in astrocytes
Maja Potokar Matja Stenovec Mateja Gabrijel Lizhen Li Marko Kreft Sonja Grilc Milos Pekny Robert Zorec 《Glia》2010,58(10):1208-1219
Intermediate filament (IF) proteins upregulation is a hallmark of astrocyte activation and reactive gliosis, but its pathophysiological implications remain incompletely understood. A recently reported association between IFs and directional mobility of peptidergic vesicles allows us to hypothesize that IFs affect vesicle dynamics and exocytosis‐mediated astrocyte communication with neighboring cells. Here, we ask whether the trafficking of recycling vesicles (i.e., those fused to and then retrieved from the plasma membrane) and endosomes/lysosomes depends on IFs. Recycling vesicles were labeled by antibodies against vesicle glutamate transporter 1 (VGLUT1) and atrial natriuretic peptide (ANP), respectively, and by lysotracker, which labels endosomes/lysosomes. Quantitative fluorescence microscopy was used to monitor the mobility of labeled vesicles in astrocytes, derived from either wild‐type (WT) mice or mice deficient in glial fibrillary acidic protein and vimentin (GFAP−/−Vim−/−), the latter lacking astrocyte IFs. Stimulation with ionomycin or ATP enhanced the mobility of VGLUT1‐positive vesicles and reduced the mobility of ANP‐positive vesicles in WT astrocytes. In GFAP−/−Vim−/− astrocytes, both vesicle types responded to stimulation, but the relative increase in mobility of VGLUT1‐positive vesicles was more prominent compared with nonstimulated cells, whereas the stimulation‐dependent attenuation of ANP‐positive vesicles mobility was reduced compared with nonstimulated cells. The mobility of endosomes/lysosomes decreased following stimulation in WT astrocytes. However, in GFAP−/−Vim−/− astrocytes, a small increase in the mobility of endosomes/lysosomes was observed. These findings show that astrocyte IFs differentially affect the stimulation‐dependent mobility of vesicles. We propose that upregulation of IFs in pathologic states may alter the function of astrocytes by deregulating vesicle trafficking. © 2010 Wiley‐Liss, Inc. 相似文献
138.
Skin pigmentation in animals is an important trait with many functions. The present study focused on two closely related salmonid species, marble trout (Salmo marmoratus) and brown trout (S. trutta), which display an uncommon labyrinthine (marble‐like) and spot skin pattern, respectively. To determine the role of chromatophore type in the different formation of skin pigment patterns in the two species, the distribution and ultrastructure of chromatophores was examined with light microscopy and transmission electron microscopy. The presence of three types of chromatophores in trout skin was confirmed: melanophores; xanthophores; and iridophores. In addition, using correlative microscopy, erythrophore ultrastructure in salmonids was described for the first time. Two types of erythrophores are distinguished, both located exclusively in the skin of brown trout: type 1 in black spot skin sections similar to xanthophores; and type 2 with a unique ultrastructure, located only in red spot skin sections. Morphologically, the difference between the light and dark pigmentation of trout skin depends primarily on the position and density of melanophores, in the dark region covering other chromatophores, and in the light region with the iridophores and xanthophores usually exposed. With larger amounts of melanophores, absence of xanthophores and presence of erythrophores type 1 and type L iridophores in the black spot compared with the light regions and the presence of erythrophores type 2 in the red spot, a higher level of pigment cell organisation in the skin of brown trout compared with that of marble trout was demonstrated. Even though the skin regions with chromatophores were well defined, not all the chromatophores were in direct contact, either homophilically or heterophilically, with each other. In addition to short‐range interactions, an important role of the cellular environment and long‐range interactions between chromatophores in promoting adult pigment pattern formation of trout are proposed. 相似文献
139.
Inflammation Research - 相似文献
140.
Carrie M. Durward Mateja Savoie-Roskos Abiodun Atoloye Patrice Isabella Melanie D. Jewkes Brenda Ralls Kathleen Riggs Heidi LeBlanc 《Journal of nutrition education and behavior》2019,51(3):342-347