全文获取类型
收费全文 | 18821篇 |
免费 | 1441篇 |
国内免费 | 492篇 |
专业分类
耳鼻咽喉 | 190篇 |
儿科学 | 351篇 |
妇产科学 | 403篇 |
基础医学 | 2483篇 |
口腔科学 | 341篇 |
临床医学 | 2038篇 |
内科学 | 3596篇 |
皮肤病学 | 425篇 |
神经病学 | 1262篇 |
特种医学 | 820篇 |
外国民族医学 | 3篇 |
外科学 | 2425篇 |
综合类 | 1421篇 |
一般理论 | 5篇 |
预防医学 | 1163篇 |
眼科学 | 471篇 |
药学 | 1515篇 |
4篇 | |
中国医学 | 335篇 |
肿瘤学 | 1503篇 |
出版年
2023年 | 166篇 |
2022年 | 363篇 |
2021年 | 639篇 |
2020年 | 352篇 |
2019年 | 459篇 |
2018年 | 470篇 |
2017年 | 409篇 |
2016年 | 428篇 |
2015年 | 595篇 |
2014年 | 697篇 |
2013年 | 783篇 |
2012年 | 1260篇 |
2011年 | 1359篇 |
2010年 | 828篇 |
2009年 | 722篇 |
2008年 | 1031篇 |
2007年 | 1063篇 |
2006年 | 1025篇 |
2005年 | 951篇 |
2004年 | 860篇 |
2003年 | 696篇 |
2002年 | 638篇 |
2001年 | 500篇 |
2000年 | 438篇 |
1999年 | 445篇 |
1998年 | 213篇 |
1997年 | 210篇 |
1996年 | 244篇 |
1995年 | 197篇 |
1994年 | 159篇 |
1993年 | 106篇 |
1992年 | 209篇 |
1991年 | 195篇 |
1990年 | 172篇 |
1989年 | 151篇 |
1988年 | 147篇 |
1987年 | 120篇 |
1986年 | 116篇 |
1985年 | 116篇 |
1984年 | 90篇 |
1983年 | 80篇 |
1982年 | 70篇 |
1981年 | 69篇 |
1980年 | 55篇 |
1979年 | 61篇 |
1978年 | 62篇 |
1977年 | 42篇 |
1976年 | 29篇 |
1975年 | 31篇 |
1974年 | 47篇 |
排序方式: 共有10000条查询结果,搜索用时 406 毫秒
11.
12.
Matthew D. Li Katrina F. Chu Allegra DePietro Vincent Wu Eric Wehrenberg-Klee Omar Zurkiya Raymond W. Liu Suvranu Ganguli 《Journal of vascular and interventional radiology : JVIR》2019,30(3):314-319
Purpose
To evaluate the feasibility of a same-day yttrium-90 (90Y) radioembolization protocol with resin microspheres (including pretreatment angiography, lung shunt fraction [LSF] determination, and radioembolization) for the treatment of hepatocellular carcinoma (HCC) and liver metastases.Materials and Methods
All same-day radioembolization procedures performed over 1 y (February 2017 to January 2018) were included in this single-institutional retrospective analysis, in which 34 procedures were performed in 26 patients (median age, 63 y; 13 women), 19 with liver metastases and 7 with HCC. Yttrium-90 treatment activities were calculated by body surface area method. Tumor imaging response was assessed by Response Evaluation Criteria In Solid Tumors (RECIST) 1.1 for liver metastases and modified RECIST for HCC. Clinical side effects and adverse events were graded per Common Terminology Criteria for Adverse Events version 4.0.Results
All planned cases were technically successful, and no cases were canceled for elevated LSF or vascular anatomic reasons. Pretreatment angiography modified the planned 90Y treatment activity in 1 case in which vascular anatomy required a lobar-dose split into 2 for segmental infusions. In 18% of cases, patients were briefly admitted after the procedure for observation or symptom management. Imaging evaluation of initial efficacy at 1 month demonstrated partial response in 25% and stable disease in 67% of patients with liver metastases and partial/complete response in 43% and stable disease in 14% of patients with HCC. Grade ≥ 3 adverse events occurred in 6% of cases, with no systemic therapy–limiting toxicities. The mean total procedure time was 4.2 hours.Conclusions
A same-day 90Y radioembolization protocol with resin microspheres is feasible in select patients, which can expedite cancer therapy. 相似文献13.
14.
15.
16.
17.
R. H. Wiesner B. J. Steffen K. M. David A. H. Chu R. D. Gordon J. R. Lake 《American journal of transplantation》2006,6(7):1609-1616
Mycophenolate mofetil (MMF) used in a triple-drug regimen has been shown to decrease acute rejection rates, compared to a double-drug regimen. The impact of MMF on late acute rejection (LAR) episodes has not been well described. To investigate the risk of LAR (rejection > or = 6 months post-transplantation) data from the Scientific Registry of Transplant Recipients (SRTR) were used. We studied adult primary liver transplant recipients transplanted between June 1, 1995, and April 30, 2004, with hepatitis C virus (HCV) (n = 3356), hepatitis B virus (HBV) (n = 550) or a nonviral (n = 5740) primary cause of liver disease who were recorded as receiving continuous 3-(MMF + Tacro + steroids) versus 2-drug (Tacro + steroids) therapy for at least 6 months immediately post transplantation. Kaplan-Meier analysis showed significantly lower LAR rates 4 years post-transplant in 3- versus 2-drug HCV, HBV and nonviral disease patients. Multivariate regression confirmed 3- versus 2-drug therapy to be associated with a decreased risk of LAR. Late graft survival was significantly lower at 4 years post-transplant for patients with LAR 6-12 months post-transplantation versus patients with early rejection (78.0% vs. 87.0%, p < 0.001) and no rejection (88.1%, p < 0.001). Three-drug versus 2-drug therapy for a minimum of 6 months may offer a better treatment strategy to avoid the consequences and expense of LAR episodes. 相似文献
18.
K U Chu S Higashide B M Evers S Rajaraman J Ishizuka C M Townsend Jr J C Thompson 《Annals of surgery》1994,220(4):570-577
OBJECTIVE: The authors determined whether bombesin could improve survival from methotrexate (MTX)-induced enterocolitis. SUMMARY BACKGROUND DATA: Bombesin prevents gut mucosal atrophy, which is produced by feeding rats an elemental diet. Administration of MTX produces a lethal enterocolitis in rats fed an elemental diet. METHODS: On treatment day 0, 60 rats were divided randomly into three groups and fed an elemental diet (Vivonex TEN, Sandoz, Minneapolis, MN) as the only source of nutrition. Groups were subdivided further to receive either saline or bombesin (10 micrograms/kg, subcutaneously, three times a day) beginning either on day 0 or day 14. Methotrexate (20 mg/kg, intraperitoneally) was given to all rats 14 days after the start of an elemental diet. RESULTS: Bombesin prevented the mucosal atrophy in the ileum produced by the elemental diet and significantly decreased mortality in rats given MTX (whether given as a pretreatment or at the time of MTX administration). CONCLUSION: Bombesin significantly improved survival in a lethal model of MTX-induced enterocolitis, possibly by maintaining gut mucosal structure. Administration of bombesin to patients receiving chemotherapy may be clinically useful in preventing the severe enterocolitis induced by various chemotherapeutic agents. 相似文献
19.
Sonoelasticity imaging of prostate cancer: in vitro results 总被引:2,自引:0,他引:2
20.
Ferdinand Heinrich Koss 《Journal of molecular medicine (Berlin, Germany)》1938,17(44):1537-1538
Ohne Zusammenfassung 相似文献