全文获取类型
收费全文 | 10148篇 |
免费 | 1297篇 |
国内免费 | 40篇 |
专业分类
耳鼻咽喉 | 157篇 |
儿科学 | 363篇 |
妇产科学 | 198篇 |
基础医学 | 1217篇 |
口腔科学 | 850篇 |
临床医学 | 944篇 |
内科学 | 2323篇 |
皮肤病学 | 388篇 |
神经病学 | 622篇 |
特种医学 | 315篇 |
外科学 | 1645篇 |
综合类 | 219篇 |
一般理论 | 4篇 |
预防医学 | 581篇 |
眼科学 | 230篇 |
药学 | 623篇 |
中国医学 | 48篇 |
肿瘤学 | 758篇 |
出版年
2024年 | 7篇 |
2023年 | 100篇 |
2022年 | 290篇 |
2021年 | 497篇 |
2020年 | 351篇 |
2019年 | 560篇 |
2018年 | 618篇 |
2017年 | 474篇 |
2016年 | 533篇 |
2015年 | 469篇 |
2014年 | 590篇 |
2013年 | 734篇 |
2012年 | 699篇 |
2011年 | 810篇 |
2010年 | 531篇 |
2009年 | 380篇 |
2008年 | 465篇 |
2007年 | 453篇 |
2006年 | 398篇 |
2005年 | 414篇 |
2004年 | 375篇 |
2003年 | 302篇 |
2002年 | 259篇 |
2001年 | 166篇 |
2000年 | 142篇 |
1999年 | 124篇 |
1998年 | 61篇 |
1997年 | 46篇 |
1996年 | 49篇 |
1995年 | 39篇 |
1994年 | 26篇 |
1993年 | 30篇 |
1992年 | 34篇 |
1991年 | 24篇 |
1990年 | 27篇 |
1989年 | 31篇 |
1988年 | 43篇 |
1987年 | 50篇 |
1986年 | 42篇 |
1985年 | 37篇 |
1984年 | 32篇 |
1983年 | 17篇 |
1982年 | 11篇 |
1981年 | 16篇 |
1979年 | 13篇 |
1978年 | 7篇 |
1977年 | 12篇 |
1975年 | 10篇 |
1969年 | 7篇 |
1966年 | 8篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
91.
Stanley Crankson Mohammed J Al Salman Khalid A Al Mane Abdullah A Al Zaben 《Tropical gastroenterology》2004,25(1):47-48
We report the case of a 7-month-old boy who presented with a history of vomiting since birth. A computed tomography study showed circumferential thickening of the lower oesophageal wall with enhancement of the mucosa. After a period of antireflux medication, the patient underwent simultaneous oesophageal dilatation and Nissen fundoplication. He is doing well at 2-year follow up. 相似文献
92.
93.
The objective of our study was to determine the influence of gender and age of onset on the outcome in Saudi children with systemic lupus erythematosus (SLE). Medical records of children with SLE treated at King Faisal Specialist Hospital and Research Center were reviewed. Outcome measures included Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index score (SLICC/ACR), renal disease requiring dialysis, or transplant and death related to SLE. Patients were classified based on age at disease onset into early onset (<5 years) and late onset (>5 years). Data were analyzed, and comparison was made according to the gender and age groups. Eighty-nine patients (76 female and 13 male) were included. The median disease duration was 5 years. Twelve patients had early-onset disease. There was no difference in the mean age, age at diagnosis, disease duration, and follow-up between the different groups. Logistic regression analysis showed significant association of high SLICC/ACR score with early-onset disease and male gender, while renal disease requiring dialysis and renal transplant was associated significantly with male gender independently of age of disease onset. In contrast, death related to SLE was influenced by early-onset disease. Male children and early onset disease of this cohort had poorer outcome. This finding indicates that gender and early-onset disease influence the long-term outcome of SLE in children. 相似文献
94.
Harry Gibbs Ben Freedman Mårten Rosenqvist Saverio Virdone Wael Al Mahmeed Giuseppe Ambrosio A. John Camm Barry Jacobson Carlos Jerjes-Sanchez Gloria Kayani Ali Oto Elizaveta Panchenko Hany Ragy Ajay K. Kakkar 《The American journal of medicine》2021,134(7):893-901.e11
BackgroundAsymptomatic atrial fibrillation is often detected incidentally. Prognosis and optimal therapy for asymptomatic compared with symptomatic atrial fibrillation is uncertain. This study compares clinical characteristics, treatment, and 2-year outcomes of asymptomatic and symptomatic atrial fibrillation presentations.MethodsGlobal Anticoagulant Registry in the Field-Atrial Fibrillation (GARFIELD-AF) is a global, prospective, observational study of newly diagnosed atrial fibrillation with ≥1 stroke risk factors (http://www.clinicaltrials.gov, unique identifier: NCT01090362). Patients were characterized by atrial fibrillation-related symptoms at presentation and the CHA2DS2-VASc score. Two-year follow-up recorded anticoagulation patterns (vitamin K antagonist, direct oral anticoagulants, parenteral therapy) and outcomes (stroke/systemic embolism, all-cause mortality, and bleeding).ResultsAt presentation, of 52,032 eligible patients, 25.4% were asymptomatic and 74.6% symptomatic. Asymptomatic patients were slightly older (72 vs 70 years), more often male (64.2% vs 52.9%), and more frequently initiated on anticoagulation ± antiplatelets (69.4% vs 66.0%). No difference in events (adjusted hazard ratios, 95% confidence interval) for nonhemorrhagic stroke/systemic embolism (1.19, 0.97-1.45), all-cause mortality (1.06, 0.94-1.20), or bleeding (1.02, 0.87-1.19) was observed. Anticoagulation was associated with comparable reduction in nonhemorrhagic stroke/systemic embolism (0.59, 0.43–0.82 vs 0.78, 0.65–0.93) and all-cause mortality (0.69, 0.59-0.81 vs 0.77, 0.71-0.85) in asymptomatic versus symptomatic, respectively.ConclusionsMajor outcomes do not differ between asymptomatic and symptomatic atrial fibrillation presentations and are comparably reduced by anticoagulation. Opportunistic screening-detected asymptomatic atrial fibrillation likely has the same prognosis as asymptomatic atrial fibrillation at presentation and likely responds similarly to anticoagulation thromboprophylaxis. 相似文献
95.
Reem J. Al Argan Safi G. Alqatari Abir H. Al Said Raed M. Alsulaiman Abdulsalam Noor Lameyaa A. Al Sheekh Fedaa H. Al Beladi 《Medicine》2021,100(19)
Introduction:Corona virus disease-2019 (COVID-19) presents primarily with respiratory symptoms. However, extra respiratory manifestations are being frequently recognized including gastrointestinal involvement. The most common gastrointestinal symptoms are nausea, vomiting, diarrhoea and abdominal pain. Gastrointestinal perforation in association with COVID-19 is rarely reported in the literature.Patient concerns and diagnosis:In this series, we are reporting 3 cases with different presentations of gastrointestinal perforation in the setting of COVID-19. Two patients were admitted with critical COVID-19 pneumonia, both required intensive care, intubation and mechanical ventilation. The first one was an elderly gentleman who had difficult weaning from mechanical ventilation and required tracheostomy. During his stay in intensive care unit, he developed Candidemia without clear source. After transfer to the ward, he developed lower gastrointestinal bleeding and found by imaging to have sealed perforated cecal mass with radiological signs of peritonitis. The second one was an obese young gentleman who was found incidentally to have air under diaphragm. Computed tomography showed severe pneumoperitoneum with cecal and gastric wall perforation. The third case was an elderly gentleman who presented with severe COVID-19 pneumonia along with symptoms and signs of acute abdomen who was confirmed by imaging to have sigmoid diverticulitis with perforation and abscess collection.Interventions:The first 2 cases were treated conservatively. The third one was treated surgically.Outcome:Our cases had a variable hospital course but fortunately all were discharged in a good clinical condition.Conclusion:Our aim from this series is to highlight this fatal complication to clinicians in order to enrich our understanding of this pandemic and as a result improve patients’ outcome. 相似文献
96.
Tawfiq M. Al Antary Hussein Estityah Nizar Haddad Eman T. Al-Antary 《Toxin reviews》2015,34(4):190-194
Chlorinated pesticide residues in human breast milk from five southern Jordan districts were analyzed in 2012/2013. The total number of samples from all districts was 100. The number of samples gathered from each district was collected according to their population densities. The present study shows that 59% of the samples which contained pesticides’ residues were p,p’-DDE, 30% contained β-HCH, 10% contained p,p′-DDT, 6% contained α-HCH, 2% contained heptachlor and 1% contained endrin. These human milk samples were free of aldrin, dieldrin, α-endosulfan, β-endosulfan, HCB, γ-HCH, o,p′-DDD, o,p′-DDT and o,p′-DDE. The levels of the six mentioned compounds detected in all mother’s milk samples were higher in Ghor El-Safi district compared with the other four districts. In this study, it is recommended to continue the pesticides residues monitoring in all parts of Jordan, particularly in Ghor El-Safi district and other regions in the cultivated Jordan Valley. 相似文献
97.
98.
This report evaluates the diagnostic method in 167 patients with colonic schistosomiasis. These patients formed a part of a large number of patients who had sigmoidoscopy or colonoscopy for various gastrointestinal problems. During sigmoidoscopy or colonoscopy examination, typical intestinal Schistosomia lesions could be seen and at the same time several biopsies could be taken. Stool examination showed Schistosoma mansoni ova in only 19 patients (11.37%) of the 167 patients whose colonic biopsies were positive for Schistosoma mansoni. Serological tests were carried out in 115 of these patients and 88 patients (52.69%) had a titre of 64 or more. This study shows that endoscopic colonic biopsy is a better method than stool examination and serological tests in the diagnosis of intestinal or hepatosplenic schistosomiasis. 相似文献
99.
Dr. José V. Roig M.D. Carlos Villoslada M.D. Salvador Lledó M.D. Amparo Solana M.D. Elvira Buch M.D. Rafael Alós M.D. Joaquín Hinojosa M.D. 《Diseases of the colon and rectum》1995,38(9):952-958
PURPOSE: A prospective study was made of the prevalence and associations of pudendal neuropathy in 96 patients with fecal incontinence (72 females and 24 males). METHODS: Clinical exploration, perineal level measurement, anorectal manometry, and electrophysiologic evaluations (pudendal nerve terminal motor latency (PNTML) and external sphincter fiber density (FD)) were performed. RESULTS: Pudendal neuropathy (defined as PNTML>2.2 ms or FD>1.65) was found in 67 patients (69.8 percent) and was more common in females (75 percent) than in males (50 percent;P
= 0.05). Pudendal neuropathy was also more frequent in patients with pathologic perineal descent (85 percent
vs.
55 percent;P
<0.01) or exhibiting risk factors such as difficult labor or excessive defecatory straining (P
<0.01). Perineal level at straining correlated inversely with both PNTML and FD (P
<0.01). Manometric findings suggested greater external anal sphincter damage in patients with pudendal neuropathy than in those suffering fecal incontinence but no neuropathy (P
<0.05). Pressure caused by the striated anal sphincter was also inversely correlated to PNTML. Pudendal neuropathy was encountered in 37 of 63 (58.7 percent) patients with sphincter injury
vs.in 31 of 33 (93.9 percent) patients with idiopathic fecal incontinence (P
< 0.01). CONCLUSIONS: Pudendal neuropathy is an etiologic or associated factor often present in patients with fecal incontinence. In this sense, clinical, perineometric, and manometric findings correlate with pudendal neuropathy, though such explorations do not suffice to detect it.Read at the meeting of The American Society of Colon and Rectal Surgeons, Orlando, Florida, May 8 to 13, 1994. 相似文献
100.
Sequential hydrophile and lipophile solubilization as an efficient method for decellularization of porcine aortic valve leaflets: Structure,mechanical property and biocompatibility study 下载免费PDF全文
Wei‐hua Qiao Peng Liu Dan Hu Mahmoud Al Shirbini Xian‐ming Zhou Nian‐guo Dong 《Journal of tissue engineering and regenerative medicine》2018,12(2):e828-e840
Antigenicity of xenogeneic tissues is the major obstacle to increased use of these materials in clinical medicine. Residual xenoantigens in decellularized tissue elicit the immune response after implantation, causing graft failure. With this in mind, the potential use is proposed of three protein solubilization‐based protocols for porcine aortic valve leaflets decellularization. It was demonstrated that hydrophile solubilization alone achieved incomplete decellularization; lipophile solubilization alone (LSA) completely removed all cells and two most critical xenoantigens – galactose‐α(1,3)‐galactose (α‐Gal) and major histocompatibility complex I (MHC I) – but caused severe alterations of the structure and mechanical properties; sequential hydrophile and lipophile solubilization (SHLS) resulted in a complete removal of cells, α‐Gal and MHC I, and good preservation of the structure and mechanical properties. In contrast, a previously reported method using Triton X‐100, sodium deoxycholate and IGEPAL CA‐630 resulted in a complete removal of all cells and MHC I, but with remaining α‐Gal epitope. LSA‐ and SHLS‐treated leaflets showed significantly reduced leucocyte activation (polymorphonuclear elastase) upon interaction with human blood in vitro. When implanted subdermally in rats for 6 weeks, LSA‐ or SHLS‐treated leaflets were presented with more biocompatible implants and all four decellularized leaflets were highly resistant to calcification. These findings illustrate that the SHLS protocol could be considered as a promising decellularization method for the decellularization of xenogeneic tissues in tissue engineering and regenerative medicine. Copyright © 2016 John Wiley & Sons, Ltd. 相似文献