全文获取类型
收费全文 | 196452篇 |
免费 | 17784篇 |
国内免费 | 13392篇 |
专业分类
耳鼻咽喉 | 1547篇 |
儿科学 | 2330篇 |
妇产科学 | 2866篇 |
基础医学 | 21831篇 |
口腔科学 | 3195篇 |
临床医学 | 25198篇 |
内科学 | 29715篇 |
皮肤病学 | 1992篇 |
神经病学 | 10240篇 |
特种医学 | 7148篇 |
外国民族医学 | 100篇 |
外科学 | 20686篇 |
综合类 | 33906篇 |
现状与发展 | 36篇 |
一般理论 | 21篇 |
预防医学 | 13601篇 |
眼科学 | 5057篇 |
药学 | 20783篇 |
194篇 | |
中国医学 | 10851篇 |
肿瘤学 | 16331篇 |
出版年
2024年 | 610篇 |
2023年 | 2799篇 |
2022年 | 7171篇 |
2021年 | 8953篇 |
2020年 | 6810篇 |
2019年 | 6016篇 |
2018年 | 6301篇 |
2017年 | 5835篇 |
2016年 | 5385篇 |
2015年 | 8405篇 |
2014年 | 10555篇 |
2013年 | 10177篇 |
2012年 | 14917篇 |
2011年 | 16464篇 |
2010年 | 10719篇 |
2009年 | 8797篇 |
2008年 | 10959篇 |
2007年 | 10915篇 |
2006年 | 10682篇 |
2005年 | 10231篇 |
2004年 | 7067篇 |
2003年 | 6530篇 |
2002年 | 5558篇 |
2001年 | 4786篇 |
2000年 | 4698篇 |
1999年 | 4544篇 |
1998年 | 2953篇 |
1997年 | 2850篇 |
1996年 | 2086篇 |
1995年 | 1928篇 |
1994年 | 1629篇 |
1993年 | 1085篇 |
1992年 | 1456篇 |
1991年 | 1263篇 |
1990年 | 1112篇 |
1989年 | 994篇 |
1988年 | 843篇 |
1987年 | 788篇 |
1986年 | 600篇 |
1985年 | 548篇 |
1984年 | 294篇 |
1983年 | 211篇 |
1982年 | 144篇 |
1981年 | 140篇 |
1980年 | 89篇 |
1979年 | 137篇 |
1978年 | 65篇 |
1976年 | 56篇 |
1975年 | 56篇 |
1974年 | 68篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
71.
72.
73.
Xue Yao Yan Zhang Jian Hao Hui-Quan Duan Chen-Xi Zhao Chao Sun Bo Li Bao-You Fan Xu Wang Wen-Xiang Li Xuan-Hao Fu Yong Hu Chang Liu Xiao-Hong Kong Shi-Qing Feng 《中国神经再生研究》2019,(3)
Ferroptosis is an iron-dependent novel cell death pathway. Deferoxamine, a ferroptosis inhibitor, has been reported to promote spinal cord injury repair. It has yet to be clarified whether ferroptosis inhibition represents the mechanism of action of Deferoxamine on spinal cord injury recovery. A rat model of Deferoxamine at thoracic 10 segment was established using a modified Allen's method. Ninety 8-week-old female Wistar rats were used. Rats in the Deferoxamine group were intraperitoneally injected with 100 mg/kg Deferoxamine 30 minutes before injury. Simultaneously, the Sham and Deferoxamine groups served as controls. Drug administration was conducted for 7 consecutive days. The results were as follows:(1) Electron microscopy revealed shrunken mitochondria in the spinal cord injury group.(2) The Basso, Beattie and Bresnahan locomotor rating score showed that recovery of the hindlimb was remarkably better in the Deferoxamine group than in the spinal cord injury group.(3) The iron concentration was lower in the Deferoxamine group than in the spinal cord injury group after injury.(4) Western blot assay revealed that, compared with the spinal cord injury group, GPX4, xCT, and glutathione expression was markedly increased in the Deferoxamine group.(5) Real-time polymerase chain reaction revealed that, compared with the Deferoxamine group, mRNA levels of ferroptosis-related genes Acyl-CoA synthetase family member 2(ACSF2) and iron-responsive element-binding protein 2(IREB2) were up-regulated in the Deferoxamine group.(6) Deferoxamine increased survival of neurons and inhibited gliosis. These findings confirm that Deferoxamine can repair spinal cord injury by inhibiting ferroptosis. Targeting ferroptosis is therefore a promising therapeutic approach for spinal cord injury. 相似文献
74.
目的研究快速成型(RP)技术辅助下制作的个体化假体复合珊瑚羟基磷灰石(CHA)、重组人骨形成蛋白2(rhBMP-2)修复兔下颌骨缺损的成骨效果。
方法以27只新西兰大白兔为实验对象,随机数字表法平均分成3组(每组9只),全部建立下颌骨连续性缺损模型,并在兔下颌骨缺损区分别植入个体化假体+自体骨(A组)、个体化假体+CHA(B组)、个体化假体+CHA+rhBMP-2(C组)。分别于术后4、12、24周3个时间点处死动物取材,进行大体标本观察,以及骨钙素(OC)、Ⅰ型胶原(COL-1)的免疫组化观察,分别比较各组修复骨缺损的能力,并对实验数据进行重复测量设计资料的单因素方差分析。
结果术后24周各组实验兔外形均对称,通过OC及COL-1的吸光度检测,骨缺损区均有大量新骨形成,A组(0.537 ± 0.010)、C组(0.530 ± 0.010)可见大量骨小梁及编织骨结构,缺损区的新骨OC、COL-1的免疫组化观察基本一致,差异无统计学意义(t = 0.007,P>0.05);但A组强于B组(0.415 ± 0.009,t = 0.122,P<0.001);C组也强于B组(t = 0.121,P<0.001),差异均有统计学意义。
结论在兔下颌骨缺损修复中,通过RP技术和组织工程技术相结合,CHA复合rhBMP-2后成骨能力明显增强,成骨效能肯定,为后期的临床应用提供可靠的实验基础。 相似文献
75.
76.
77.
Feng He Yuanjun Ma Shi Li Haozhe Ren Qian Liu Xiaohua Chen Hui Miao Tao Ye Qian Lu Zuge Yang Tianle Li Xin Tong Hongxu Yang Mian Zhang Helin Wang Yazhou Wang Shibin Yu 《Journal of bone and mineral research》2022,37(5):1044-1055
Temporomandibular joint osteoarthritis (TMJOA) is a chronic degenerative disease for which the underlying mechanism still remains unclear. Compared with apoptosis and autophagy, necroptosis causes greater harm to tissue homeostasis by releasing damage-associated molecular patterns (DAMPs). However, the role of necroptosis and downstream key DAMPs in TMJOA is unknown. Here, rodent models of TMJOA were established by the unilateral anterior crossbite (UAC). Transmission electron microscopy (TEM) and immunohistochemistry of receptor interacting protein kinase 3 (RIPK3)/phosphorylation of mixed lineage kinase domain-like protein (pMLKL) were conducted to evaluate the occurrence of necroptosis in vivo. The therapeutic effects of blocking necroptosis were achieved by intra-articularly injecting RIPK3 or MLKL inhibitors and using RIPK3 or MLKL knockout mice. In vitro necroptosis of condylar chondrocyte was induced by combination of tumor necrosis factor alpha (TNFα), second mitochondria-derived activator of caspases (SMAC) mimetics and carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]- fluoromethylketone (z-VAD-fmk). The possible DAMPs released by necroptotic chondrocytes were screened by quantitative proteomics and blocked by specific antibody. Translucent cytosol, swollen organelles, and ruptured cell membranes, features of necroptosis, were frequently manifested in chondrocytes at the early stage of condylar cartilage degeneration in TMJOA, which was accompanied by upregulation of RIPK3/pMLKL. Inhibiting or knocking out RIPK3/MLKL significantly prevented cartilage degeneration. DAMPs released by necroptotic condylar chondrocytes, such as syndecan 4 (SDC4) and heat shock protein 90 (HSP90), were verified. Furthermore, blocking the function of SDC4 significantly attenuated the expression of TNFα in cartilage and synovium, and accordingly increased cartilage thickness and reduced synovial inflammation. Thus, the necroptotic vicious cycle of TNFα-SDC4-TNFα contributes to cartilage degeneration and synovitis, and can serve as a potential therapeutic target for treating TMJOA. © 2022 American Society for Bone and Mineral Research (ASBMR). 相似文献
78.
Growth Hormone Induces Recurrence of Infantile Hemangiomas After Apparent Involution: Evidence of Growth Hormone Receptors in Infantile Hemangioma
下载免费PDF全文
![点击此处可从《Pediatric dermatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Naikhoba C. O. Munabi B.A. Qian Kun Tan H.S. Maria C. Garzon M.D. Gerald G. Behr M.D. Carrie J. Shawber Ph.D. June K. Wu M.D. 《Pediatric dermatology》2015,32(4):539-543
Infantile hemangiomas (IHs) are the most common benign tumor of infancy, characterized by a natural history of early proliferation in the first months of life to eventual involution during childhood, often with residual fibrofatty tissue. Once involution has been achieved, IHs do not typically recur. We present two cases of exogenous growth hormone therapy resulting in the recurrence of IHs in late childhood, supported by radiological, immunohistochemical, in vitro, and in vivo evidence. 相似文献
79.
80.
Yuan-Zhang Tang Bai-Shan Wu Li-Qiang Yang Jian-Ning Yue Liang-Liang He Na Li Jia-Xiang Ni 《Medicine》2015,94(45)
To evaluate the efficacy of computed tomography (CT) guided single radiofrequency thermocoagualtion (RFT) in 1137 patients with idiopathic trigeminal neuralgia after a follow-up period of 11 years, specially focused on duration of pain relief in different branches of trigeminal nerve, side effect, and complications.Retrospective study of patients with idiopathic trigeminal neuralgia treated with a single CT guided RFT procedure between January 2002 and December 2013.The mean follow-up time was 46.14 ± 30.91 months. Immediate postprocedure pain relief was 98.4%. V2 division obtained the best pain relief rate: 91%, 89%, 80%, 72%, 60%, and 54% at 1, 3, 5, 7, 9, and 11 years, respectively. No statistical difference pairwise comparison was in other groups. The complications included masseter muscle weakness, corneitis, diplopia, ptosis, hearing loss, limited mouth opening, and low pressure headache. Masticatory weakness mostly occurred in patients with V3 branch involvement, while Corneitis and Diplopia all in patients with V1 branch involvement. No mortalities observed during or after RFT.All different branches division of trigeminal neuralgia achieved comparable satisfactory curative effect; V2 obtained the best excellent pain relief, after RFT procedure. Facial numbness is inevitable after RFT, which patients who have pain in all 3 trigeminal divisions and patients who desire no facial numbness should be cautious. Masticatory weakness is mainly related with V3 injured, while Corneitis and Diplopia in patients with V1 injured by RFT. 相似文献