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81.
82.
Raimondo L Ferrara I Stefano AD Cella CA D'Armiento FP Ciancia G Moretto R Renzo AD Carlomagno C 《International journal of hematology》2012,95(3):320-323
Primary hepatic lymphoma is an extremely rare malignancy accounting for 0.016% of all cases of non-Hodgkin lymphomas. Approximately
1–4% of histologies described show a follicular pattern. We report a case of primary hepatic non-Hodgkin lymphoma that developed
in a middle-aged woman 3 years after radical treatment (neoadjuvant chemoradiotherapy and surgery) for a rectal adenocarcinoma.
Abdomen ultrasound showed a single nodule in the liver, which raised the issue of differential diagnosis with a metastasis
from rectal cancer. After surgical removal of the nodule, histology revealed a primary B cell, stage IE follicular non-Hodgkin
lymphoma, confined to the liver; indeed, no foci of lymphoma were found elsewhere in the body. 相似文献
83.
Keller E. Santos C. Cusack D. Väli M. Ferrara D. Ludes B. Mangin P. Payne-James J. J. Vieira D. N. 《International journal of legal medicine》2019,133(1):317-322
International Journal of Legal Medicine - Article 25 of the Charter of Fundamental Rights of the European Union (adopted in Nice on 7 December 2000) recognizes and respects the rights of older... 相似文献
84.
Salomone Erica Settanni Michele McConachie Helen Suma Katharine Ferrara Federica Foletti Giulia Salandin Arianna Servili Chiara Adamson Lauren B. 《Journal of autism and developmental disorders》2022,52(10):4286-4300
Journal of Autism and Developmental Disorders - Parents of children with ASD (N?=?86; mean age 44.8 months; 67 boys) were randomized to either WHO Caregiver Skills Training... 相似文献
85.
Giuseppe Rengo Gennaro Pagano Dino Franco Vitale Roberto Formisano Klara Komici Laura Petraglia Valentina Parisi Grazia Daniela Femminella Claudio de Lucia Stefania Paolillo Alessandro Cannavo Emilio Attena Teresa Pellegrino Santo Dellegrottaglie Alessia Memmi Bruno Trimarco Alberto Cuocolo Pasquale Perrone Filardi Dario Leosco Nicola Ferrara 《European journal of nuclear medicine and molecular imaging》2016,43(13):2392-2400
Purpose
Sympathetic nervous system (SNS) hyperactivity is a salient characteristic of chronic heart failure (HF) and contributes to the progression of the disease. Iodine-123 meta-iodobenzylguanidine (123I-mIBG) imaging has been successfully used to assess cardiac SNS activity in HF patients and to predict prognosis. Importantly, SNS hyperactivity characterizes also physiological ageing, and there is conflicting evidence on cardiac 123I-mIBG uptake in healthy elderly subjects compared to adults. However, little data are available on the impact of ageing on cardiac sympathetic nerve activity assessed by 123I-mIBG scintigraphy, in patients with HF.Methods and results
We studied 180 HF patients (age?=?66.1?±?10.5 years [yrs]), left ventricular ejection fraction (LVEF?=?30.6?±?6.3 %) undergoing cardiac 123I-mIBG imaging. Early and late heart to mediastinum (H/M) ratios and washout rate were calculated in all patients. Demographic, clinical, and echocardiographic data were also collected. Our study population consisted of 53 patients aged >75 years (age?=?77.7?±?4.0 year), 67 patients aged 62–72 years (age?=?67.9?±?3.2 years) and 60 patients aged ≤61 year (age?=?53.9?±?5.6 years). In elderly patients, both early and late H/M ratios were significantly lower compared to younger patients (p?<?0.05). By multivariate analysis, H/M ratios (both early and late) and washout rate were significantly correlated with LVEF and age.Conclusions
Our data indicate that, in a population of HF patients, there is an independent age-related effect on cardiac SNS innervation assessed by 123I-mIBG imaging. This finding suggests that cardiac 123I-mIBG uptake in patients with HF might be affected by patient age.86.
Slow eye movements and subjective estimates of sleepiness predict EEG power changes during sleep deprivation 总被引:1,自引:0,他引:1
Marzano C Fratello F Moroni F Pellicciari MC Curcio G Ferrara M Ferlazzo F De Gennaro L 《Sleep》2007,30(5):610-616
RATIONALE: The aim of the present study was to assess, intraindividually, the relationship among slow eye movements, electroencephalogram (EEG) power, and subjective measures of sleepiness during a 40-hour sleep deprivation comparing 2 experimental conditions: eyes-open and eyes-closed. METHODS: Nineteen normal subjects participated in a sleep-deprivation protocol with recordings of the waking Cz-A1-2 EEG in 36 sessions at 1-hour intervals starting at 10:00 AM. Each session consisted of a 2-minute eyes-closed period, followed by a 4-minute eyes-open period. Electrooculogram, self-ratings (Karolinska Sleepiness Scale and Visual Analog Scale for Global Vigor), and tympanic temperature were also recorded. RESULTS: Changes in sleepiness and alertness are paralleled by increases in slow eye movements and theta and delta EEG power. The beginning of the rise of delta, theta, and slow eye movement activity corresponded to the nadir of temperature, peaking at 7:00AM. Cross-correlational analyses showed that changes in slow eye movements were strictly phase locked to those in slow-frequency EEG bands and in subjective measures. The comparison of time intervals that were equivalent with respect to circadian phase confirms the effects of the increased sleepiness on slow eye movement activity and on the other measures. The temporal concordance of the different physiologic and subjective measures is also reflected in the individual time courses. Individual and group analyses converged in indicating that slow eye movements can be considered reliable indexes of sleepiness but only in the eyes-closed condition. CONCLUSIONS: Results suggest that subjective and EEG changes associated with higher sleepiness are paralleled by an increase in slow eye movement activity, but this relationship exists almost exclusively with the eyes closed. Hence, its use in practical and operational contexts seems limited. 相似文献
87.
The extracellular presence of the adenine nucleotides ATP and ADP induces calcium mobilization in vascular endothelial cells
(ECs). ATP/ADP concentration at the EC surface is determined by a balance of convective-diffusive transport to and from the
EC surface, hydrolysis by ectonucleotidases at the cell surface, and flow-induced ATP release from ECs. Our previous numerical
simulations in a parallel plate geometry had demonstrated that flow-induced ATP release has a profound effect on nucleotide
concentration at the EC surface. In the present study, we have extended the modeling to probe the impact of flow separation
and recirculation downstream of a backward facing step (BFS) on ATP/ADP concentration at the EC surface. The results show
that for both steady and pulsatile flow over a wide range of wall shear stresses, the ATP + ADP concentration at the EC surface
is considerably lower within the flow recirculation region than in areas of undisturbed flow outside the recirculation zone.
Pulsatile flow also leads to sharp temporal gradients in nucleotide concentration. If confirmed experimentally, the present
findings suggest that disturbed and undisturbed flow may affect EC calcium mobilization differently. Such differences might,
in turn, contribute to the observed endothelial dysfunction in regions of disturbed flow. 相似文献
88.
Shojaei F Ferrara N 《Laboratory investigation; a journal of technical methods and pathology》2007,87(3):227-230
Identification and characterization of several important regulators of angiogenesis, and FDA approval of the first antiangiogenic drugs, has opened a new era in the therapy of cancer and neovascular age-related macular degeneration. This brief review focuses on the progress in targeting one of the major regulators of angiogenesis, VEGF-A, and also discusses potential cellular and molecular mechanisms underlying resistance to antiangiogenic treatments. 相似文献
89.
90.
Andrea Lechiancole Igor Vendramin Sandro Sponga Giorgio Guzzi Veronica Ferrara Chiara Nalli Concetta Di Nora Uberto Bortolotti Ugolino Livi 《Clinical transplantation》2020,34(10):e14043
To evaluate the impact of donor-recipient age matching on clinical outcomes after heart transplantation, a total of 509 patients (January 1990-December 2018, mean follow-up 111 ± 80 months) were stratified into 4 groups (young-R/young-D, young-R/old-D, old-R/young-D, old-R/old-D) according to the recipient (young-R < 60, old-R ≥ 60 years) and the donor (young-D < 50, old-D ≥ 50 years) age. No difference was found among 30-day mortality (P = .11) and postoperative complications between groups. Both unadjusted and adjusted survival was significantly higher for group young-R/young-D than that of other groups, in which survival was similar [adjusted HR for mortality of 2.0(1.2-3.4), 2.1(1.4-3.8) and 2.5(1.6-4.1) for groups old-R/young-D, young-R/old-D, old-R/old-D, respectively]. Compared to other groups, the incidence of grade ≥ 2 CAV was significantly lower in old-R/young-D group [adjusted HR 0.4(0.2-0.7)]. Among young recipients, the rate of acute grade ≥ 2 rejection episodes was higher in those receiving an old donor graft (P = .04). Old recipient groups were more affected by neoplasms and severe renal failure than young recipient groups (P < .01). Employment of hearts from donors ≥50 years of age adversely affects survival in recipients <60 years of age but does not influence outcomes in older recipients. Also, donor and recipient ages seem to have opposite effects on incidence of rejections and CAV of high grade. 相似文献