全文获取类型
收费全文 | 713篇 |
免费 | 27篇 |
国内免费 | 77篇 |
专业分类
儿科学 | 31篇 |
妇产科学 | 56篇 |
基础医学 | 60篇 |
口腔科学 | 6篇 |
临床医学 | 97篇 |
内科学 | 155篇 |
皮肤病学 | 15篇 |
神经病学 | 64篇 |
特种医学 | 96篇 |
外科学 | 42篇 |
综合类 | 24篇 |
预防医学 | 9篇 |
眼科学 | 5篇 |
药学 | 62篇 |
1篇 | |
中国医学 | 1篇 |
肿瘤学 | 93篇 |
出版年
2022年 | 10篇 |
2021年 | 9篇 |
2020年 | 5篇 |
2019年 | 6篇 |
2018年 | 10篇 |
2017年 | 5篇 |
2016年 | 13篇 |
2015年 | 19篇 |
2014年 | 21篇 |
2013年 | 26篇 |
2012年 | 29篇 |
2011年 | 30篇 |
2010年 | 17篇 |
2009年 | 22篇 |
2008年 | 11篇 |
2007年 | 67篇 |
2006年 | 27篇 |
2005年 | 36篇 |
2004年 | 26篇 |
2003年 | 13篇 |
2002年 | 12篇 |
2001年 | 18篇 |
2000年 | 22篇 |
1999年 | 15篇 |
1998年 | 24篇 |
1997年 | 34篇 |
1996年 | 26篇 |
1995年 | 23篇 |
1994年 | 19篇 |
1993年 | 15篇 |
1992年 | 6篇 |
1991年 | 10篇 |
1990年 | 11篇 |
1989年 | 19篇 |
1988年 | 19篇 |
1987年 | 11篇 |
1986年 | 14篇 |
1985年 | 15篇 |
1984年 | 7篇 |
1983年 | 6篇 |
1982年 | 14篇 |
1981年 | 15篇 |
1980年 | 10篇 |
1979年 | 5篇 |
1978年 | 8篇 |
1977年 | 7篇 |
1976年 | 10篇 |
1975年 | 10篇 |
1974年 | 2篇 |
1971年 | 2篇 |
排序方式: 共有817条查询结果,搜索用时 15 毫秒
811.
Most methods of measuring neutrophil motility provide information mainly about the performance of a small proportion of the fastest moving cells. Application of a computer-linked image analysis technique, using the "Quantimet," provides a convenient, automated method of measuring the motility of the whole cell population. This makes it possible to test whether changes in motility represent a homogeneous alteration affecting all cells or a change in the numbers or performance of a subset of cells. In this study the neutrophils from patients with uncomplicated rheumatoid arthritis were found to perform similarly to normals, while cells from patients with Felty's syndrome were markedly slower. This was an overall, homogeneous slowing of the whole cell population, not due to a loss of fast moving cells. 相似文献
812.
There has been a significant improvement in survival rates over the last decade as a result of advances in the treatment of cancer in children. One of the consequences of chemotherapy may be damage to the ovarian function, which can lead to loss of fertility. Methods of fertility protection have been developed for adult women as a result of advances in reproductive medicine, which make the option of becoming pregnant after surviving cancer realistic. However, only some of the methods can be used in prepubescent girls and adolescents. In addition, a higher number of miscarriages and premature births have been found in women who underwent pelvic radiotherapy during childhood or adolescence and the children were more commonly growth retarded. The effects of cancer treatment on the ovarian function and later fertility should be discussed at the start of treatment. 相似文献
813.
Yu-Chuan Lee Henry HL Chan Martin M Black 《The Australasian journal of dermatology》1996,37(4):205-207
Polyfibromatosis syndrome is a condition characterized by the occurrence of several cutaneous fibrotic conditions including Dupuytren's contracture and keloid formation. A 10 year follow-up of a patient with an aggressive type of polyfibromatosis associated with erosive arthropathy is presented. The underlying pathogenesis and management of this uncommon condition is discussed. 相似文献
814.
According to the German guidelines, patients with borderline ovarian tumors require bilateral salpingo-oophorectomy, which leads to loss of fertility. Cohort studies and case reports demonstrate that fertility-sparing surgery (unilateral salpingo-oophorectomy or cystectomy) is an option in these patients. In addition, modern fertility-preservation measures could be offered to these patients, including controlled ovarian stimulation with cryopreservation of oocytes as well as cryopreservation of ovarian tissue. All patients with a (prospective) desire to have children must be provided with detailed information on the possible options for fertility preservation as well as on the possible risks. After completion of family planning, subsequent removal of the remnant ovarian tissue to minimize the risk of recurrence should be discussed. 相似文献
815.
816.
817.
Genetic variants in VEGF pathway genes in neoadjuvant breast cancer patients receiving bevacizumab: Results from the randomized phase III GeparQuinto study
下载免费PDF全文
![点击此处可从《International journal of cancer. Journal international du cancer》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Gunter von Minckwitz Lothar Häberle Holger Eidtmann Hans Tesch Michael Untch Jörn Hilfrich Christian Schem Mahdi Rezai Bernd Gerber Serban Dan Costa Jens‐Uwe Blohmer Kathrin Schwedler Kornelia Kittel Tanja Fehm Georg Kunz Matthias W. Beckmann Arif B. Ekici Claus Hanusch Jens Huober Cornelia Liedtke Christine Mau Matthieu Moisse Volkmar Müller Valentina Nekljudova Gilian Peuteman Brigitte Rack Matthias Rübner Thomas Van Brussel Liewei Wang Richard M. Weinshilboum Sibylle Loibl Peter A. Fasching 《International journal of cancer. Journal international du cancer》2015,137(12):2981-2988
Studies assessing the effect of bevacizumab (BEV) on breast cancer (BC) outcome have shown different effects on progression‐free and overall survival, suggesting that a subgroup of patients may benefit from this treatment. Unfortunately, no biomarkers exist to identify these patients. Here, we investigate whether single nucleotide polymorphisms (SNPs) in VEGF pathway genes correlate with pathological complete response (pCR) in the neoadjuvant GeparQuinto trial. HER2‐negative patients were randomized into treatment arms receiving either BEV combined with standard chemotherapy or chemotherapy alone. In a pre‐planned biomarker study, DNA was collected from 729 and 724 patients, respectively from both treatment arms, and genotyped for 125 SNPs. Logistic regression assessed interaction between individual SNPs and both treatment arms to predict pCR. Five SNPs may be associated with a better response to BEV, but none of them remained significant after correction for multiple testing. The two SNPs most strongly associated, rs833058 and rs699947, were located upstream of the VEGF‐A promoter. Odds ratios for the homozygous common, heterozygous and homozygous rare rs833058 genotypes were 2.36 (95% CI, 1.49–3.75), 1.20 (95% CI, 0.88–1.64) and 0.61 (95% CI, 0.34–1.12). Notably, some SNPs in VEGF‐A exhibited a more pronounced effect in the triple‐negative subgroup. Several SNPs in VEGF‐A may be associated with improved pCR when receiving BEV in the neoadjuvant setting. Although none of the observed effects survived correction for multiple testing, our observations are consistent with previous studies on BEV efficacy in BC. Further research is warranted to clarify the predictive value of these markers. 相似文献