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741.
742.
1 材料和方法1. 1 材料 我院 2003 02 /2004 12对子宫肌瘤、子宫腺肌症,采用腹式横切口鞘内全子宫切除术 26例.同时随机选择 22例常规全子宫切除术宫颈楔形切除术作为对照组,两组年龄分别为 43±4(38~52)岁, 41±6(38 ~53)岁,患者年龄,手术适应证及子宫大小两组间无显著性差异,具有可比性.1. 2 方法 ①连续硬膜外麻醉,取膀胱截石位,采用耻 2~3横形切 10~12cm,仅切开皮肤,撕开脂肪及筋膜,钝性加锐性分离肌肉与筋膜粘着处,钝性分离腹直肌,腹膜剪一小横口,切开腹膜.用腹纱牵开肠宫,大块纱布排垫肠管,大弯钳钳夹子宫两角尽量钳拉子宫至腹腔… 相似文献
743.
Gilda Schmidt Christoph Gerlinger Ingolf Juhasz-Böss Elmar Stickeler Achim Rody Cornelia Liedtke Pauline Wimberger Theresa Link Eberhard Müller Tanja Fehm Manuela Abel Stefan Stein Rainer Bohle Jan Endrikat Erich-Franz Solomayer 《Journal of cancer research and clinical oncology》2016,142(6):1369-1376
744.
The catechol‐O‐methyltransferase (COMT) Val158Met genotype modulates working memory‐related dorsolateral prefrontal response and performance in bipolar disorder 下载免费PDF全文
745.
Slow wave sleep (SWS) is characterized by maximum release of growth hormone (GH) and minimum release of cortisol. We hypothesized that this hormonal pattern during SWS leads, in addition to generally increased T cell cytokine production, to a shift towards type1 cytokines. To test this hypothesis, blood was sampled from 8 humans during SWS, and whole blood cultures were activated in-vitro with ionomycin and phorbol-myrestate-acetate (PMA) in the absence and presence of GH neutralizing antibody (Ab) or physiological concentrations of cortisol. Production of interferon-gamma (IFN-gamma), interleukin-2 (IL-2), IL-4, and tumor necrosis factor-alpha (TNF-alpha) was measured using multiparametric flow cytometry. GH Ab decreased IFN-gamma+CD4+ cells but had no effect on other cytokines. Cortisol alone and in combination with GH Ab decreased CD4+ and CD8+ cells producing IFN-gamma, TNF-alpha and IL-2. Simultaneously, these two reactants reduced IL-4+CD4+ cells, so that the ratio of IFN-gamma/IL4 producing CD4+ cells indicated an unexpected shift towards type1 dominance. Results support the view that release of GH by increasing particularly production of IFN-gamma can contribute to the shift in type1/type2 balance towards type1 activity characterizing SWS. Suppression of cortisol during this sleep period enhances both type1 and type2 activity. Yet, our finding of predominant type1 activity after cortisol administration, rules out any relevance of this suppression for the shift towards type1 activity during SWS. 相似文献
746.
747.
Schultes B Kern W Oltmanns K Peters A Gais S Fehm HL Born J 《Psychoneuroendocrinology》2005,30(2):149-161
Antecedent hypoglycemia is known to attenuate hormonal and symptomatic responses to subsequent hypoglycemia. Whether this pertains also to hypoglycemia-induced cognitive dysfunction is controversially discussed. Neurocognitive adaptation might essentially depend on the type of function. Here, we compared the influence of recurrent hypoglycemia in 15 healthy men on counterregulatory hormones, subjective symptoms of hypoglycemia, short-term memory performance (word recall), and performance on an auditory attention task (oddball). The attention task was also used to record event-related brain potential (ERP) indicators of stimulus processing. In each subject, three consecutive hypoglycemic clamps were performed, two on day 1 and the third on day 2. Neurocognitive testing was performed during baseline and at two different hypoglycemic plateaus (2.8 and 2.5 mmol/l) during the first and last clamp. As expected, hormonal responses were significantly reduced to the last as compared to the first hypoglycemia indicating adaptation. Subjective symptoms also decreased in response to recurrent hypoglycemia. Short-term memory performance deteriorated distinctly on the first hypoglycemic clamp, but maintained the normal level on the last clamp (P=0.006). Likewise, the impairment in reaction time (P=0.022) and response accuracy (P=0.005) was distinctly smaller on the last than first hypoglycemia. In parallel, the hypoglycemia-induced decrease in P3 amplitude (P=0.019) and the increase in P3 latency (P=0.049) were diminished with recurrent hypoglycemia, indicating that late stages of controlled stimulus processing likewise adapted. In contrast, the distinct decrease in amplitudes of the N1 and P2 components of the ERP (preceding the P3) was closely comparable in response to the first and last hypoglycemia (P>0.3). Together results indicate an adaptation to recurrent hypoglycemia for signs of controlled stimulus processing presumably involving hippocampo-prefrontocortical circuitry, while earlier automatic stages of processing appear to be spared. 相似文献
748.
Fibrin sealants are used in a variety of surgical procedures, mainly for purposes of hemostasis and assisted wound healing. The combined use of fibrin sealant and autologous muscle pads for hemostasis was not reported previously. Arterial incisions in the common carotid artery in rats were closed by the combined application of fibrin sealant and an autologous muscle pad. Postsurgical vessel patency and degree of stenosis were evaluated by color duplex sonography, computed tomography angiography, and postmortem histology. The combined application of muscle pad and fibrin sealant and achievement of hemostasis was feasible in all animals. Seventy-eight percent of animals showed no or only slight postsurgical vessel stenosis. Our method is simple and quick to perform, showing a high potential for hemostasis in microvascular lesions. Therefore, it might be used in future experimental studies for conservation of vessel patency after arterial catheterization and in experimental or clinical vascular surgery. 相似文献
749.
Sniffing neuropeptides: a transnasal approach to the human brain 总被引:11,自引:0,他引:11
750.