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91.
Recent reports have demonstrated that the HIV-1 transactivator protein,tat, induces apoptosis in T-lymphocyte cell lines, as well as in peripheral blood mononuclear cells, and stimulates a cascade
of events resulting in up-regulation of the potent immunosuppressive cytokine, transforming growth factor-β (TGF-β). In this
study we evaluated the ability of TGF-β to mediatetat induced apoptosis in T-lymphocyte cell lines. T-cells treated exogenously with either TGF-β1 or a combination of tat and
pan-specific TGF-β neutralizing antibodies showed little change in the amount of apoptosis. When treated with pan-specific
TGF-β neutralizing antibodies, Jurkat cells that stably expresstat protein (Jurkat-tat) showed only a modest decrease in apoptosis, while CEM-TART cells (CEM T-cells expressing both HIV-1tat andrev) demonstrated little change in the amount of apoptosis. In conclusion, we have demonstrated that TGF-β does not play a significant
role in mediatingtat induced T-cell apoptosis. 相似文献
92.
93.
Hypertension in pregnancy managed at home by community midwives 总被引:1,自引:0,他引:1
J G Feeney 《British medical journal (Clinical research ed.)》1984,288(6423):1046-1047
94.
Commentary on acute renal failure in Asian region 总被引:1,自引:0,他引:1
95.
At a moment when dogs were anticipating the presentation of a visual stimulus which would predict the delivery of food, the second of a pair of thalamocortical evoked potentials (30 msec interstimulus interval) in the visual system decreased in amplitude relative to control periods whereas similar measures in the auditory system increased. Opposite effects were obtained in dogs anticipating an auditory stimulus. These data were interpreted as reflecting selective changes in sensory channels during selective attention. 相似文献
96.
A sensitive and specific GLC determination of plasma bucainide was developed using a nitrogen-specific detector. The method permits the determination of bucainide as low as 5.0 ng/ml of plasma and provides sufficient sensitivity and reproducibility for clinical use. 相似文献
97.
98.
Feeney KT Dowse GK Keil AD Mackaay C McLellan D 《Communicable diseases intelligence》2005,29(4):386-390
Scarlet fever was associated with feared outbreaks and mortality in the 19th Century. It occurs sporadically in modern society and infection is readily treated with antibiotics. We report on a scarlet fever outbreak in children attending a primary school in Perth, Western Australia, in late 2003. A total of 13 cases were identified over a five week period. Six of the cases were pre-primary children (ages 4 to 5) from the same class of 26 children (attack rate 23.1%). Three of the remaining seven cases were older siblings of pre-primary cases who developed scarlet fever after their younger siblings. Screening of the children and teachers from the two pre-primary classes at the school yielded 12 positive pharyngeal swabs for group A Streptococcus. Emm-typing of the screening isolates indicated that a common strain was circulating within the outbreak pre-primary class, with four of six isolates identified as emm-type 3. The overall group A Streptococcus carriage rate in screened students in this class was 31.6 per cent and the carriage rate for emm-type 3 was 21.1 per cent. Carriers were treated with oral penicillin V to eradicate carriage and control the outbreak. No further cases of scarlet fever were reported after the treatment of pharyngeal carriers. Outbreaks of scarlet fever still occur in young children and identification and treatment of carriers may still be valuable. 相似文献
99.
George Rona M.D. Neil Feeney M.D. David S. Kahn M.D. 《The American journal of cardiology》1963,12(6):869-874
A 67 year old woman died suddenly following an 18 month history of periodic attacks suggesting cardiac ischemia. Histopathologic examination showed the presence of a pedunculated aortic valvular hamartoma and plexiform vascular structures of the lungs. It is suggested that the former were responsible for the clinical attacks and sudden death by completely obstructing the orifice of the right coronary artery. The pulmonary lesions resulted in some right ventricular hypertrophy and possibly contributed to the unusual clinical features. 相似文献
100.