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91.
Pedro Carrilho-Ferreira Ana G. Almeida Fausto J. Pinto 《Current heart failure reports》2014,11(4):393-403
Left ventricular non-compaction (LVNC) is thought to arise from arrest of the normal process of trabecular remodeling or “compaction” that takes place during embryonic life and is characterized by the presence of a two-layered ventricular wall, with a compact epicardial layer and a non-compacted endocardial layer. It is an uncommon condition that can occur isolated or in association with other disorders, including congenital heart anomalies and mitochondrial or musculoskeletal disorders. Both familial and sporadic forms are recognized, and several responsible genes have been identified, although only a minority of patients can be successfully genotyped. The diagnosis is usually made by echocardiography, but cardiac magnetic resonance imaging has been used increasingly. Management is mainly empirical and directed at the major clinical manifestations: heart failure, arrhythmias, and systemic embolic events. This article will review the major features of LVNC and present new trends in the diagnosis and management of this intriguing condition. 相似文献
92.
93.
Poorly differentiated neuroendocrine carcinomas (PDNECs) of the gastroenteropancreatic system (GEP) are a heterogeneous group of aggressive malignancies with a high propensity for distant metastases and an ominous prognosis. They have traditionally been divided into small and large cell subtypes on morphological grounds. However, histological diagnosis needs to be supported by immunohistochemistry to avoid possible misdiagnoses either with the more frequent poorly differentiated adenocarcinomas and squamous cell carcinomas or with lymphomas and mesenchymal neoplasms. Although it is well known that GEP PDNECs are associated with a poor prognosis, data from some published studies seem to suggest that there is a fraction of patients with PDNECs who have better survival than expected. GEP PDNECs are currently classified according to the criteria proposed in the 2010 WHO classification. They are simply called neuroendocrine carcinomas (NECs) and are defined by mitotic count >20?×?10 HPF and/or Ki-67 labeling index >20 %. However, a few recent papers have indicated that some NECs, as defined by the 2010 WHO scheme, do not show a poorly differentiated morphology as expected. This category seems to show a better prognosis and, especially, does not respond to cisplatin-based chemotherapy, which represents the goal standard therapeutic approach to high-grade PDNECs. In the present review, the main morphological, immunohistochemical, and prognostic features will be discussed as well as the opportunity to introduce a new category characterized by well to moderately differentiated morphology associated with high proliferation (mitotic count >20?×?10 HPF and/or Ki-67 index >20 %). 相似文献
94.
Fausto Biancari Tomas Gudbjartsson Jouni Heikkinen Vesa Anttila Timo Mäkikallio Anders Jeppsson Linda Thimour-Bergström Carmelo Mignosa Antonino S. Rubino Kari Kuttila Jarmo Gunn Jan-Ola Wistbacka Kari Teittinen Kari Korpilahti Francesco Onorati Giuseppe Faggian Giulia Vinco Corrado Vassanelli Flavio Ribichini Tatu Juvonen Tomas A. Axelsson Axel F. Sigurdsson Pasi P. Karjalainen Ari Mennander Olli Kajander Markku Eskola Erkki Ilveskoski Veronica D'Oria Marisa De Feo Tuomas Kiviniemi K.E. Juhani Airaksinen 《The American journal of cardiology》2014
95.
Ardenghi TM Vargas-Ferreira F Piovesan C Mendes FM 《Oral health & preventive dentistry》2012,10(1):17-27
Purpose: To assess the age the of the first dental visit and the association of self-perceived oral health, socioeconomic and clinical indicators with healthcare utilisation in Brazilian preschool children. Materials and Methods: An epidemiological survey with 455 5- to 59-month-old children was conducted on National Children's Vaccination Day in Santa Maria, RS, Brazil. Data about age and reasons for the first dental visit, healthcare utilisation, socioeconomic status and self-perceived oral health were collected by means of a parental semi-structured questionnaire. Calibrated examiners evaluated the prevalence of dental caries (WHO) and dental trauma. The assessment of the association used Poisson regression models (prevalence ratio; 95% confidence interval [CI]). Results: A total of 24.2% (95% CI: 20.3% to 28.4%) of the study sample had already had a first dental visit. Older children, those with dental caries and dental trauma and whose mothers had a higher level of education were more likely to have gone to the dentist. Children of low socioeconomic status were more likely to have visited public than private healthcare services. The reasons for the first dental visit were associated with clinical indicators of the sample. The distribution of utilisation of the types of oral healthcare services (public or private) varied across the socioeconomic groups. Non-white children with dental caries and dental trauma tended to visit a dentist only for treatment reasons. Conclusion: Socioeconomic and clinical indicators are associated with the use of dental services, indicating the need for strategies to promote public health and reorientation of services that facilitate dental access for preschool children. 相似文献
96.
Petrelli F Borgonovo K Cabiddu M Lonati V Barni S 《Journal of cancer research and clinical oncology》2012,138(2):179-187
Background
Iron supplementation could improve the hematopoietic response of erythropoiesis-stimulating agents (ESAs) used for chemotherapy-induced anemia. 相似文献97.
R?mulo?Vaz?Machry Simone?Tuchtenhagen Bernardo?Antonio?Agostini Carlos?Roberto?da Silva Teixeira Chaiana?Piovesan Fausto?Medeiros?Mendes Thiago?Machado?ArdenghiEmail author 《BMC oral health》2013,13(1):60
Background
Disparities in utilization of oral healthcare services have been attributed to socioeconomic and individual behavioral factors. Parents’ socioeconomic status, demographics, schooling, and perceptions of oral health may influence their children’s use of dental services. This cross-sectional study assessed the relationships between socioeconomic and psychosocial factors and the utilization of dental health services by children aged 1–5 years.Methods
Data were collected through clinical exams and a structured questionnaire administered during the National Day of Children’s Vaccination. A Poisson regression model was used to estimate prevalence ratios and 95% confidence intervals.Results
Data were collected from a total of 478 children. Only 112 (23.68%) were found to have visited a dentist; 67.77% of those had seen the dentist for preventive care. Most (63.11%) used public rather than private services. The use of dental services varied according to parental socioeconomic status; children from low socioeconomic backgrounds and those whose parents rated their oral health as “poor” used dental services less frequently. The reason for visiting the dentist also varied with socioeconomic status, in that children of parents with poor socioeconomic status and who reported their child’s oral health as “fair/poor” were less likely to have visited the dentist for preventive care.Conclusion
This study demonstrated that psychosocial and socioeconomic factors are important predictors of the utilization of dental care services.98.
99.
Gutierrez M Luccioli F Salaffi F Bartoloni E Bertolazzi C Bini V Filipucci E Grassi W Gerli R 《Clinical rheumatology》2012,31(3):463-468
This study was conducted to determine the prevalence of subclinical entheseal involvement at the greater trochanter level
by ultrasound in patients with spondyloarthritis. Forty-six patients with spondyloarthritis and 46 healthy age- and sex-matched
controls were studied. All patients with no clinical evidence of enthesopathy at the greater trochanter underwent an ultrasound
examination. The following three entheses were scanned bilaterally: anterior insertion of gluteus minimus, anterior insertion
of gluteus medius, and posterior insertion of gluteus medius. Ultrasound findings of enthesopathy were thickening, calcifications,
bone erosions, enthesophytes, bursitis, and power Doppler signal. A total of 276 entheses were evaluated in spondyloarthritis
patients. In 112 out of 276 (40.5%), grayscale ultrasound found enthesopathy. The enthesis with the highest number of signs
of enthesopathy was the anterior insertion of gluteus medius (46/276) (16%), followed by posterior insertion of gluteus medius
(37/276) (13.4%) and anterior insertion of gluteus minimus (29/276) (10.5%). In the healthy population, ultrasound found entesopathy
in 80 out of 276 (29%) entheseal sites (p < 0.0001). Posterior insertion of gluteus medius enthesis was the more frequently involved (34/276) (12.3%), followed by
anterior insertion of gluteus medius (24/276) (8.6%) and anterior insertion of gluteus minimus (22/276) (7.9%). Power Doppler
was found more frequently in patients with spondyloarthritis compared with healthy controls (1% vs 0%). Our results show a
higher prevalence of subclinical enthesopathy at the greater trochanter level in patients with spondyloarthritis than in age-
and sex-matched healthy controls. 相似文献
100.
Franchignoni F Salaffi F Giordano A Ciapetti A Carotti M Ottonello M 《Clinical rheumatology》2012,31(1):113-121
The aim of this study is to perform a psychometric analysis of the Lequesne Algofunctional Indexes (LAI) for the severity
of osteoarthritis (OA) of the hip (LAI-hip) and knee (LAI-knee), using classical test theory (CTT) and Rasch analysis. Questionnaires
were completed by 1,214 patients with symptomatic OA of the knee (n = 697) and hip (n = 517). Internal consistency was evaluated using Cronbach’s alpha and an item-to-total correlation. Dimensionality was investigated
with a factor analysis. Raw scores underwent Rasch analysis. Cronbach’s alpha was 0.84 for LAI-hip and 0.82 for LAI-knee.
LAI-hip resulted in unidimensionality according to the factor analysis, while LAI-knee supported both a single and a two-factor
solution (items 1–6b and 7–10, respectively). At Rasch analysis, the rating categories of item ‘maximum distance walked’ did
not comply with the criteria for category functioning in either LAI-hip or LAI-knee. A test of the residual correlation showed
item dependency in both LAI-hip and LAI-knee. Misfitting items were present in both the scales. According to both CTT and
Rasch analysis, in our two samples representing a wide spectrum of both hip and knee OA severity the LAI-hip and LAI-knee
showed a series of drawbacks, which rendered both questionnaires inadequate in relation to their metric properties and severely
limit their ability to perform, as a composite measure, in line with the main aims of their developers. 相似文献