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71.
Neutrophil function response to aerobic and anaerobic exercise in female judoka and untrained subjects
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OBJECTIVES: Recent studies have indicated reduced immunity in trained athletes. AIM: To assess the effects of aerobic and anaerobic exercise on the phagocytic process in 18-26 year old trained female judoka (n = 8) and untrained controls (n = 7). METHODS: Each subject participated randomly in two different testing sessions (aerobic, 20 minutes of treadmill running at 70-80% of maximal heart rate; anaerobic, Wingate anaerobic test). Venous blood samples were drawn before, immediately after, and 24 hours after each session. RESULTS: There were no significant differences in basal values of net chemotaxis (chemotaxis--random migration), bactericidal activity, and superoxide anion release between the judoka and the untrained women. There was a significant decrease in net chemotaxis 24 hours after the aerobic exercise in both the judoka (from 64 (19) to 39 (13) cells/field, p < 0.02) and the untrained controls (from 60 (7) to 47 (12) cells/field, p < 0.05). Bactericidal activity and superoxide anion release did not change significantly after aerobic exercise in either group. There were no significant changes in net chemotaxis, bactericidal activity, and superoxide anion release after anaerobic exercise in either the judoka or untrained women. CONCLUSIONS: The decrease in net chemotaxis after aerobic, but not after anaerobic, exercise, suggests that net chemotaxis is affected by the combination of exercise intensity and duration, and not by the exercise intensity itself. Similar effects of both exercise sessions in the judoka and the untrained women suggest that training had no effect on neutrophil function response to aerobic and anaerobic exercises. 相似文献
72.
Pamela L. Strissel Matthias Ruebner Falk Thiel David Wachter Arif B. Ekici Friedericke Wolf Franziska Thieme Klemens Ruprecht Matthias W. Beckmann Reiner Strick 《Oncotarget》2012,3(10):1204-1219
Endometrial carcinoma (EnCa) is the most common invasive gynaecologic carcinoma. Over 85% of EnCa are classified as endometrioid, expressing steroid hormone receptors and mostly involving pathological prestages. Human endogenous retroviruses (ERV) are chromosomally integrated genes, account for about 8% of the human genome and are implicated in the etiology of carcinomas. The majority of ERV envelope (env) coding genes are either not present or not consistently represented between common gene expression microarrays. The aim of this study was to analyse the absolute gene expression of all known 21 ERV env genes including 19 codogenic and two env genes with premature stop codons in EnCa, endometrium as well as in hyperplasia and polyps. For EnCa seven env genes had high expression with >200 mol/ng cDNA (e.g. envH1-3, Syncytin-1, envT), two middle >50 mol/ng cDNA (envFc2, erv-3) and 12 low <50 mol/ng cDNA (e.g. Syncytin-2, envV2). Regarding tumor parameters, Syncytin-1 and Syncytin-2 were significantly over-expressed in advanced stage pT2 compared to pT1b. In less differentiated EnCa Syncytin-1, erv-3, envT and envFc2 were significantly over-expressed. Syncytin-1, Syncytin-2 and erv-3 were specific to glandular epithelial cells of polyps, hyperplasia and EnCa using immunohistochemistry. An analysis of 10 patient-matched EnCa with endometrium revealed that the ERV-W 5'' long terminal repeat regulating Syncytin-1 was hypomethylated, including the ERE and CRE overlapping MeCP2 sites. Functional analyses showed that 10 env genes were regulated by methylation in EnCa using the RL95-2 cell line. In conclusion, over-expressed env genes could serve as indicators for pathological pre-stages and EnCa. 相似文献
73.
Guro Løkka Lars Austbø Knut Falk Erin Bromage Per Gunnar Fjelldal Tom Hansen Ivar Hordvik Erling Olaf Koppang 《Developmental and comparative immunology》2014
Forming a barrier to the outside world, the gut mucosa faces the challenge of absorbing nutrients and fluids while initiating immune reactions towards potential pathogens. As a continuation to our previous publication focusing on the regional intestinal morphology in wild caught post smolt and spawning Atlantic salmon, we here investigate selected immune parameters and compare wild, reared unvaccinated and vaccinated post smolts. 相似文献
74.
Michael Dörks Katharina Allers Falk Hoffmann 《Journal of the American Medical Directors Association》2019,20(3):287-293.e7
Objectives
In addition to routinely administered long-term medication, complex drug regimens of nursing home residents often include as needed or pro re nata (PRN) medication. However, there has been no systematic evaluation of the frequency and concomitants of PRN medication in nursing homes. The main objective of this systematic review was to provide a current assessment of PRN drug use in nursing homes.Design
A systematic literature search was performed. Data were identified from 4 electronic bibliographic databases: MEDLINE, Embase, CINAHL, and Scopus. Studies were included if they reported quantitative data on PRN drug use in nursing home residents.Results
Our search strategy resulted in 484 hits, of which 27 articles satisfied the inclusion criteria. The mean number of PRN drugs ranged between 0.4 and 4.9 per resident with a median of 2.5. The proportion of residents prescribed at least 1 PRN drug was between 48.4% and 97.4% (median = 74.9). Administration of prescribed PRN medication was rather low as the proportion of residents with administered PRN drugs ranged from 28% to 55%. Frequently prescribed PRN drugs were analgesics, laxatives, and sedatives. Advanced age, dementia, a higher number of regularly scheduled medications, and length of stay in the nursing home were associated with higher use of PRN drugs.Conclusions/Implications
Although not regularly administered, PRN drug use in nursing home residents should be taken into account as part of complex drug regimens. In that sense, there seems to be an inadequate number of studies reporting on it. When screening tools like the Beers Criteria are adapted, PRN drugs should be included. 相似文献75.
Höfer Juliana Hoffmann Falk Dörks Michael Kamp-Becker Inge Küpper Charlotte Poustka Luise Roepke Stefan Roessner Veit Stroth Sanna Wolff Nicole Bachmann Christian J. 《Journal of autism and developmental disorders》2022,52(2):540-552
Journal of Autism and Developmental Disorders - Autism spectrum disorders (ASD) are associated with high services use, but European data on costs are scarce. Utilisation and annual costs of 385... 相似文献
76.
Dr. S.H. Sündermann Prof. Dr. V. Falk 《Zeitschrift für Herz-, Thorax- und Gef??chirurgie》2014,28(2):120-126
Heart valve disease is the most common disease of the cardiovascular system besides coronary heart disease. After aortic valve stenosis, mitral valve and tricuspid valve diseases also have a high incidence. Surgical intervention is currently the gold standard therapy. Perioperative and long-term results are excellent. An increase in the quality of life can be durably achieved for most patients. New therapies for high-risk patients are available that can be used to treat mitral valve disease without the use of a cardiopulmonary bypass. MitraClip procedures for the treatment of severe mitral valve insufficiency show good short-term results as well but comprehensive long-term results are lacking. This second part of the article summarizes the evidence and recommendations for the treatment of acquired diseases of mitral and tricuspid valves (except endocarditis) from the recent guidelines on the management of valvular heart disease which were published for the first time by the European Society of Cardiology (ESC) in conjunction with the European Association of Cardio-Thoracic Surgery. In the first part the recommendations for the treatment of aortic valve diseases were summarized. 相似文献
77.
Falk Ehmann Laura Caneva Marisa Papaluca 《British journal of clinical pharmacology》2014,77(4):612-617
Pharmacogenomics, the study of variations of DNA and RNA characteristics as related to drug response, has become an integral part of drug development and pharmacovigilance, as reflected by the incorporation of pharmacogenomic data in EU product information. In this short review article, we describe recent European Medicines Agency initiatives intended to support further the implementation of pharmacogenomics in drug development and surveillance so that patients and the public can benefit from advances in genomic science and technology. 相似文献
78.
79.
Alexander Tuan Falk Cyrus Chargari Jean-Michel Hannoun-Lévi Caroline Adrados Julie Antomarchi Jean-Baptiste Guy 《Human fertility (Cambridge, England)》2016,19(2):85-89
Fertility is a major part of the global care of patients treated for cancer. A new discipline known as oncofertility has emerged in some countries. Although the relationship between chemotherapy and external radiotherapy and fertility has been studied and reported, there is only scarce data available on brachytherapy. This systematic review aims to report available knowledge on the impact of brachytherapy on fertility. Specific consultations should be considered before brachytherapy to inform patients about their fertility preservation options. 相似文献
80.