全文获取类型
收费全文 | 2390篇 |
免费 | 137篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 75篇 |
儿科学 | 36篇 |
妇产科学 | 44篇 |
基础医学 | 347篇 |
口腔科学 | 186篇 |
临床医学 | 157篇 |
内科学 | 541篇 |
皮肤病学 | 34篇 |
神经病学 | 222篇 |
特种医学 | 37篇 |
外科学 | 207篇 |
综合类 | 2篇 |
预防医学 | 162篇 |
眼科学 | 51篇 |
药学 | 230篇 |
中国医学 | 21篇 |
肿瘤学 | 185篇 |
出版年
2024年 | 5篇 |
2023年 | 22篇 |
2022年 | 60篇 |
2021年 | 93篇 |
2020年 | 47篇 |
2019年 | 72篇 |
2018年 | 101篇 |
2017年 | 55篇 |
2016年 | 73篇 |
2015年 | 78篇 |
2014年 | 145篇 |
2013年 | 179篇 |
2012年 | 219篇 |
2011年 | 238篇 |
2010年 | 89篇 |
2009年 | 91篇 |
2008年 | 167篇 |
2007年 | 145篇 |
2006年 | 145篇 |
2005年 | 107篇 |
2004年 | 101篇 |
2003年 | 81篇 |
2002年 | 55篇 |
2001年 | 13篇 |
2000年 | 19篇 |
1999年 | 8篇 |
1998年 | 8篇 |
1997年 | 4篇 |
1996年 | 6篇 |
1995年 | 8篇 |
1994年 | 6篇 |
1993年 | 3篇 |
1992年 | 14篇 |
1991年 | 11篇 |
1990年 | 11篇 |
1989年 | 4篇 |
1988年 | 12篇 |
1987年 | 4篇 |
1986年 | 8篇 |
1985年 | 7篇 |
1984年 | 4篇 |
1980年 | 2篇 |
1979年 | 3篇 |
1975年 | 3篇 |
1974年 | 2篇 |
1971年 | 1篇 |
1970年 | 1篇 |
1969年 | 3篇 |
1961年 | 1篇 |
1944年 | 1篇 |
排序方式: 共有2537条查询结果,搜索用时 15 毫秒
81.
82.
Giuseppe Pantaleo Massimo Amato Fabiana Guerra Maria Siano Tommaso Bucci Gilberto Sammartino 《Acta stomatologica Croatica》2014,48(4):292-295
Abrikossoff’s tumour is a rare benign soft tissue neoplasm that can occur in any part of the body, including the orofacial region. The tumour is usually benign, but there are reports of cases in which the tumour shows a locally aggressive behaviour, malignancy, and distant metastases. The aetiology is unknown, since several studies have shown that different cells are involved. In the present case, a 36-year-old Dominican woman was referred to the Department of Oral and Maxillofacial Surgery in Policlinico Federico II, Naples with a circumscribed lesion and sessile nodule on the dorsum of the tongue measuring about 17 mm in diameter. The treatment consisted of an excisional biopsy performed on the basis of the diagnostic hypothesis of Abrikossoff’s tumour, which was confirmed by histopathological analysis and histochemistry and immunohistochemistry evaluation. Abrikossoff’s tumour is an uncommon neoplasm which must be carefully diagnosed considering all the histological and clinical aspects in order to be treated correctly.Key words: Granullar Cell Tumour, Soft Tissue Neoplasm, Tongue 相似文献
83.
Henrique Caballero STEINHAUSER Cecília Pedroso TURSSI Fabiana Mantovani Gomes FRAN?A Flávia Lucisano Botelho do AMARAL Roberta Tarkany BASTING 《Journal of applied oral science : revista FOB》2014,22(2):85-90
Objective
The aim of this study was to evaluate the effect of feldspathic ceramic surface cleaning on micro-shear bond strength and ceramic surface morphology.Material and Methods
Forty discs of feldspathic ceramic were prepared and etched with 10% hydrofluoric acid for 2 minutes. The discs were randomly distributed into five groups (n=8): C: no treatment, S: water spray + air drying for 1 minute, US: immersion in ultrasonic bath for 5 minutes, F: etching with 37% phosphoric acid for 1 minute, followed by 1-minute rinse, F+US: etching with 37% phosphoric acid for 1 minute, 1-minute rinse and ultrasonic bath for 5 minutes. Composite cylinders were bonded to the discs following application of silane and hydrophobic adhesive for micro-shear bond strength testing in a universal testing machine at 0.5 mm/min crosshead speed until failure. Stereomicroscopy was used to classify failure type. Surface micromorphology of each treatment type was evaluated by scanning electron microscopy at 500 and 2,500 times magnification.Results
One-way ANOVA test showed no significant difference between treatments (p=0.3197) and the most common failure types were cohesive resin cohesion followed by adhesive failure. Micro-shear bond strength of the feldspathic ceramic substrate to the adhesive system was not influenced by the different surface cleaning techniques. Absence of or less residue was observed after etching with hydrofluoric acid for the groups US and F+US.Conclusions
Combining ceramic cleaning techniques with hydrofluoric acid etching did not affect ceramic bond strength, whereas, when cleaning was associated with ultrasound, less residue was observed. 相似文献84.
85.
Fernanda Rosa Brooke Yelvington Nathan Terry Patricia Tripp Hoy E. Pittman III Bobby L. Fay Taylor J. Ross James D. Sikes Jessica B. Flowers Fabiana Bar-Yoseph Laxmi Yeruva 《Nutrients》2022,14(7)
A randomized neonatal piglet trial was conducted to evaluate the safety and the effects of a plant-based formula containing almonds and buckwheat as the main ingredients on growth and plasma parameters. From postnatal day (PND) 2 to 21, the piglets were fed a dairy-based milk formula (Similac Advance) or a plant-based formula (Else Nutrition) and all piglets were euthanized at day 21. No diarrhea was observed after PND 8 and all the piglets completed the trial. Body growth, kcal intake, the complete plasma count parameters and hematological parameters were within the reference range in both groups. Organ growth and development was similar between the two groups. Plasma glucose was higher in the dairy-based-fed piglets relative to the plant-based at 2 weeks of age. Liver function biomarkers levels were greater in the plasma of the plant-based compared to the dairy-based fed group. In addition, calcium levels were higher in the plant-based fed piglets at 1 week of age. Thus, the plant-based formula tested in this study was well tolerated by the piglets and supported similar growth compared to dairy-based milk formula. Therefore, the results support the safety of the tested plant-based infant formula during the neonatal period in comparison to the dairy-based formula fed group. 相似文献
86.
Fabiana Cardoso Vilela Marina de Mesquita Padilha Lucas dos Santos-e-Silva Geraldo Alves-da-Silva Alexandre Giusti-Paiva 《Journal of ethnopharmacology》2009
Ethnopharmacological relevance
Sonchus oleraceus L. has been used to relieve pain in Brazilian folk medicine.Aim of the study
Sonchus oleraceus L. has been used to relieve pain in Brazilian folk medicine. This study was conducted to establish the antinociceptive properties of hydroethanolic and dichloromethane extracts from aerial parts of Sonchus oleraceus in mice using chemical and thermal models of nociception.Materials and methods
The formalin, hot plate, and tail immersion tests as well as acetic acid-induced writhing were used to investigate the antinociceptive activity in mice.Results
Given orally, the extracts at test doses of 30–300 mg/kg, produced significant inhibitions on chemical nociception induced by intraperitoneal acetic acid and subplantar formalin since decreased the number of writhing episodes and the time licking. Treatment with the extracts in the same doses produced a significant increase of the reaction time in tail immersion and in the hot plate test. The extracts administered at 300 mg/kg, p.o. had a stronger antinociceptive effect than indomethacin (5 mg/kg, p.o.) and morphine (10 mg/kg, p.o.).Conclusion
The extracts of Sonchus oleraceus markedly demonstrated antinociceptive action in mice, which supports previous claims of its traditional use. 相似文献87.
Sebastian Rinaldi Davi O. Silva Fabiana Bello Celuta S. Alviano Daniela S. Alviano Maria Eline Matheus Patricia D. Fernandes 《Journal of ethnopharmacology》2009
Aim of the study
Cocos nucifera cultivated in Brazil is known as “coco-da-Bahia” or “coqueiro-da-Índia”. The tea from the husk fiber is widely used to several inflammatory disorders. Crude extract and fractions obtained from Cocos nucifera “common variety” were evaluated to test the anti-inflammatory and antinociceptive activities.Materials and methods
Crude extract (CE, 50, 100, and 150 mg/kg), fraction 1 (F1, molecular weight lesser than 1 kDa, 1, 10, and 50 mg/kg), fraction 2 (F2, molecular weight higher than 1 kDa, 1, 10, and 50 mg/kg), and the references drugs morphine (5 mg/kg), acetilsalicilic acid (200 mg/kg), prometazine (30 mg/kg), and metisergide (5 mg/kg) were evaluated on models of analgesia and inflammation.Results
CE, F1, and F2 significantly develop peripheral and central antinociceptive activity but with less effect on supra-spinal regions of the brain. Administration of the opioid antagonist, naloxone (5 mg/kg) inhibited the antinociceptive effect indicating that Cocos nucifera crude extract and fractions may be acting in opioid receptors. CE and F1 also inhibited rat paw edema induced by histamine, and serotonin.Conclusions
results demonstrated that Cocos nucifera and its fractions have antinociceptive and anti-inflammatory activities which confirm the popular use of this plant in several inflammatory disorders. 相似文献88.
89.
Molinaro V Pagliasso E Varetto G Castagno C Gibello L Zandrino F Suita R Rispoli P 《Annals of vascular surgery》2012,26(4):572.e5-572.e9
The popliteal artery (PA) entrapment syndrome, a rare cause of arterial thrombosis, is most often encountered in young male athletes. Here, we report a very unusual case of PA entrapment syndrome in a 14-year-old girl who presented with a 1-month history of calf claudication to our observation facility. Diagnostic work-up revealed obesity, sedentary lifestyle, and an aberrant accessory slip of the medial head of gastrocnemius around the PA. Arterial echo color Doppler ultrasonography and computed tomographic angiography studies were performed. Surgical treatment involved revascularization with resection of the medial head of gastrocnemius, the cause of the arterial entrapment, and enlargement angioplasty using an autologous saphenous vein patch, in combination with antiplatelet therapy, resulting in restitution ad integrum of the affected limb and, finally, an improved quality of life of the patient. This case underscores the importance of clinical suspicion, diagnosis, and treatment of lower-limb claudication in very young patients presenting with unusual symptoms. If missed, the condition may evolve dramatically. Prompt diagnosis and surgical treatment are key to complete recovery and the prevention of irreversible complications that may result in limb loss. 相似文献
90.
Thalita Marcílio Cndido Maíra Bueno Ariede Fabiana Vieira Lima Luciana de Souza Guedes Maria Valria Robles Velasco Andr Rolim Baby Catarina Rosado 《Nutrients》2022,14(6)
Skin health is not only significantly affected by ageing, but also by other lifestyle-related factors, such as sun exposure, exercise and eating habits, smoking or alcohol intake. It is known that the cutaneous tissue can exhibit visible signs of senescence, in the form of, for example, dull complexion, loss of firmness, or changes in pigmentation. Consumers attempt to improve skin health and appearance not only by cosmetic products, but also with the consumption of food supplements. Recently, there has been an increase in the amount of food supplements with claims that are related to skin and hair health. Nevertheless, the literature is still scarce in evidence of the efficacy of this type of products. Considering this scenario, we aim in this review to assemble studies and methodologies that are directed at the substantiation of the cutaneous health claims of food supplements. For example, we reviewed those that were indicative of antioxidant properties, improvement in pigmentation disorders, increased hydration or protection against the damages caused by ultraviolet radiation. 相似文献