Bone formation in a cutaneous pyogenic granuloma

Bone formation in angiomatous naevi such as strawberry naevi is recorded (Rook, 1972) but as far as we are aware ossification in a cutaneous pyogenic granuloma has not been reported.     

Evidence for a Vessel Wall Defect in Immuno-thrombocytopenic Hamsters

Experimental purpura was produced in the hamster by administration ofanti-platelet serum obtained from rabbits previously injected with hamsterplatelets. Spontaneous petechiae and generalized bleeding were observed. Thederangement in the hemostatic mechanism has been analyzed by study of thechanges in blood, bone marrow and vessel walls. The platelet count inperipheral blood fell from 9.02 ± 0.85 (x 10⁵) to 0.66 ± 0.32 (x 10⁵) at24 hours after 2.0 ml. intravenous injection of antiplatelet serum. The redcell and hemoglobin values dropped to 50 per cent before death related togeneralized bleeding occurred. Significant changes were seen in the megakaryocytes of the bone marrow. The bleeding time and clot retraction were extended. Evidence for a defect in the vessel wall has been shown by the microelectrode, moccasin snake venom and negative pressure tests. The cause ofbleeding has been postulated as a double defect resulting from a decreaseof platelets in the circulation and an alteration in the integrity of the vesselwall or perivascular supporting sheath.