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991.
K. S. Desyatnichenko A. A. Shreiner Yu. M. Ir'yanov S. N. Asonova S. A. Erofeev O. L. Grebneva S. N. Luneva E. L. Matveeva S. P. Isotova O. B. Ustyuzhanina 《Bulletin of experimental biology and medicine》1997,124(2):826-829
The effects of Stimbone-1, a complex of growth factors deposited by osteal tissue, on maturation of distraction regenerative
substrate are studied in dogs. At the end of distraction, the preparation is injected into the regenerative connective tissue
interlayer. Roentgenological, biochemical, and quantitative morphological data show that Stimbone-1 stimulates reparative
osteogenesis.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 8, pp. 233–236, August, 1997 相似文献
992.
The binding of 2G3 mouse antitheophylline monoclonal antibodies (affinity constant Kaff=2×1010 liter/mol) to theophylline is studied using isothermal titration microcalorimetry. Thermodynamic parameters of the binding
are: enthalpy change ΔH=−0.23 kcal/mol; Gibbs free energy change ΔG=−16.42 kcal/mol; entropy change ΔS=0.054 kcal/(mol×K).
Regression analysis shows a two-site kinetic binding model. A great contribution of entropy component to the free energy change
of 2G3 antibody binding to theophylline is indicative of an entropy-dependent process. The entropy-dependent nature of the
binding presumably determines the binding kinetics.
Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 124, No. 11, pp. 570–573, November, 1997 相似文献
993.
994.
高脂饲料加重大鼠阿霉素肾病的实验病理学研究 总被引:8,自引:0,他引:8
探讨高脂饲料加剧阿霉素肾病大鼠高脂血症及肾组织形态学改变的作用。用ADR静脉注射建立大鼠肾病模型,饲喂含1.5%胆固醇、5%猪油的高脂饲料,观察大鼠尿蛋白排泄量,测定血肖中脂质有关指标以及检查肾组织形态学改变。饲喂高脂饲料的ADR肾病大鼠,血清脂质水平在整个试验过程中均明显高于饲喂基础饲料的ADR肾病大鼠,肾小球病变也显著加重,饲喂高脂饲料所致高脂血症是导致大鼠ADR肾病进行性进展的重要因素之一。 相似文献
995.
用微量甲基纤维素培养方法探讨冬虫夏草结晶制剂(CS-Cr)对小鼠骨髓红系祖细胞(CFU-E和BFU-E)增殖的影响。实验结果表明,CS-Cr明显提高骨髓CFU-E和BFU-E产率、自杀率,并能对抗三尖杉酯碱对造血机能的损害。采用液体培养技术发现CS-Cr促进骨髓成纤维祖细胞(CFU-F)增殖,其产率变化与CFU-E和BFU-E产率变化一致。 相似文献
996.
应用与凝血酶原及异常凝血酶原有免疫交叉反应的非Ca(Ⅱ)依赖性抗人凝血酶原抗体,建立夹心BA-ELISA法,检测人血浆凝血酶原的最低浓度可达1ng/ml。血浆经皂土和柠檬酸钡吸附处理,除去纤维蛋白原和凝血酶原后,可用本法检出存留于血浆中的微量异常凝血酶原,并测得健康人血浆异常凝血酶原的均值为74.61±19.43ng/ml。本法操作简便,特异性强,重复性好。 相似文献
997.
Rat liver preservation. I. The components of UW solution that are essential to its success 总被引:4,自引:0,他引:4
A total of 278 orthotopic rat liver grafts, without arterialization, were performed, in an attempt to determine which of the individual components of UW solution are essential. Livers were preserved by in situ flushing and cold storage with the following results: 56% of rats survived for 1 week after 9 hr of preservation with UW solution as compared with 44% using Marshall solution, and 10% using Collins solution. Having established LD 50 for UW solution, we then omitted its components one at a time and found that omission of HES, raffinose, allopurinol, adenosine, phosphate buffer, or MgSO4 did not change survival after 9 hr of preservation. Omission of lactobionate, glutathione, and dexamethasone, respectively, resulted in decreased survival, whereas elimination of insulin surprisingly increased survival. In ensuing dose-response studies, the concentrations of lactobionate, glutahione, dexamethasone in UW solution proved to be optimal. Finally, livers were preserved with a solution containing only lactobionate, glutathione, dexamethasone, raffinose, and phosphate buffer, resulting in 53% animal survival, as compared with 56% for the unchanged UW solution. We conclude that UW solution can be simplified without loss of effectiveness in this model. 相似文献
998.
报道13例应用显徽外科技术进行输卵管绝育术后吻合术。全部病例至少随访1年。13例术后行输卵管通液术,提示输卵菅通畅(100%),13例中11例妊娠(84.62%),并复习文献,对影响手术成功的诸多因素进行讨论。 相似文献
999.
1000.
Mohamad H Yamani Randall C Starling James B Young Daniel Cook Yang Yu D Geoffrey Vince Patrick McCarthy Norman B Ratliff 《The Journal of heart and lung transplantation》2002,21(9):983-989
BACKGROUND: A cascade of inflammatory reactions characterize acute vascular rejection after heart transplantation. This study was undertaken to test the hypothesis that acute vascular rejection is associated with up-regulation of vitronectin receptor (alphavbeta3), increased expression of tissue factor, and activation of the extracellular matrix metalloproteinase induction system. METHODS: Acute vascular rejection developed in 14 heart transplant recipients within 2 weeks of transplantation, confirmed by immunofluorescence (AVR group). We compared these patients with 10 transplant recipients who had no evidence of acute vascular rejection or peritransplant ischemic injury (control group). We evaluated endomyocardial biopsy specimens for alphavbeta3, tissue factor, and extracellular matrix metalloproteinase inducer (EMMPRIN). RESULTS: Compared with the control group, the AVR group demonstrated evidence of significantly increased expression of alphavbeta3 (1.9-fold, p < 0.001), tissue factor (1.8-fold, p < 0.001), and EMMPRIN (1.5-fold, p < 0.001). All patients in the AVR group received plasmapheresis; 11 of 14 patients had evidence of ischemic necrosis on biopsy specimens, and 3 of 14 patients experienced hemodynamic compromise and graft dysfunction and died within 3 weeks of transplant. Another patient died at 10 months after transplant. CONCLUSIONS: Acute vascular rejection is associated with up-regulation of alphavbeta3, tissue factor, and activation of the matrix metalloproteinase induction system, which may contribute to the lethal morbidity associated with this disease. 相似文献