血液白细胞图象的计算机自动分割方法研究

本文提出了一套血液白细胞图象的计算机自动分割方法。实际测试表明：该方法稳定可靠且有效。单个白细胞检出成功率达９６％，区域分割吻合率平均达９４％，现已将该方法装入作者研制的白细胞自动分类识别ＬＥＵＫ分析系统的分割模块中。     

Isolation of a peptide that inhibits the posttranslational arginylation of proteins in rat brain

All eukaryotic cells contain enzymes that are able to catalyze the transfer of Arg from tRNA to the N-terminus of naturally short lived or damaged cytosolic proteins. For certain test proteins, it has been shown that the addition of Arg to the N-terminus leads to their degradation via the ubiquitin proteolytic pathway. The mechanisms used by cells for identifying proteins for arginylation and regulating arginylation are not known. The present study reports the isolation of a peptide from rat brain that is able to inhibit the arginylation of proteins in brain extracts. We suggest that this peptide is the physiological regulator of arginylation in rat brain.     

Indoor air pollution of coal fumes as a risk factor of stroke, Shanghai.

A cohort of 957 male persons in Shanghai has been followed up for 12 years after they entered a screening program for coronary heart disease and stroke. During the period of study, 24 of the subjects who had no previous history of heart disease and stroke died from stroke. Risk factors for stroke were analyzed by the Cox proportional hazards model. Coal fumes were found to be an independent risk factor for stroke in addition to diastolic blood pressure, age, and cigarette smoking.     

下腹部多个真皮下血管网皮瓣在手外伤修复中的应用

目的：应用下腹部多个真皮下血管网皮瓣修复手外伤，方法：在下腹形成以旋髂浅血管为蒂的髂腰部皮瓣及以腹壁浅血管为蒂的下腹部皮瓣，二皮瓣共蒂形成双叶皮瓣，同时将其修薄，形成有轴心血管的真皮下血管网皮瓣，修复两指完全脱套伤。在下腹部形成多个真皮下血管网的任意皮瓣，修复多个指背皮肤缺损伴有肌腱及骨外露的创面。供区如不能直接拉拢缝合，可取断层皮片修复供区创面.结果：本组10例中，8例采用下腹部双叶真皮下血管网轴型皮瓣修复，2例采用下腹部真皮下血管网任意皮瓣修复，术后效果。结论：采用多个真皮下血管网皮瓣修复手外伤的创面，伤指不需并指，去脂，分指，术后外形佳，是目前较理想的修复手外伤的手术方法。     

帕米磷酸钠和降钙素对人工关节磨损微粒引起单核细胞分泌溶骨性因子的影响

目的　探讨帕米磷酸钠和降钙素防治人工关节松动的可能性。方法　采集人体外周血 ,分离单核细胞 ,分组培养。实验分 4组 ,第 1组 :仅单核细胞 ,为对照组 ;第 2组 :单核细胞及微粒 ,为微粒组 ;第 3组 :单核细胞、微粒及帕米磷酸钠 (阿可达 ) ,为阿可达组 ;第 4组 :单核细胞、微粒及降钙素 (密钙息 ) ,为密钙息组。培养 48h后 ,检测细胞上清液中肿瘤坏死因子 (TNF) α、白细胞介素 (IL) 1和IL 6的含量。结果　微粒组的细胞上清液中溶骨性因子含量明显高于对照组 (P <0 .0 1) ;而阿可达组和密钙息组的溶骨性因子含量明显低于微粒组 (P <0 .0 1)。结论　阿可达和密钙息能有效地抑制微粒刺激单核巨噬细胞分泌溶骨性因子 ,从而间接抑制破骨细胞的活性。     

Synthesis and Pharmacological Activity of the Oxidized Fractions of Arabinogalactan from Siberian Larch (<Emphasis Type="Italic">Larix sibirica L.</Emphasis>)

Aqueous solutions of arabinogalactan from Siberian larch (Larix sibirica L.) were subjected to oxidative destruction by a hydrogen peroxide – molecular oxygen system. The obtained high- and low-molecular-weight fractions of oxidation products were characterized by chemical and spectral methods and tested for pharmacological activity. The results of experiments on animals showed evidence for significant antiulcer and antiinflammatory properties of the preparations studied. __________ Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 8, pp. 23 – 26, August, 2005.     

对LASIK手术中游离瓣的处理

目的 探讨LASIK手术中出现游离瓣的原因及处理方法。方法 对1500例（2900眼）LASIK手术中出现的9例（9眼）游离瓣进行随访观察。结果 术后1天，9例（9眼）角膜瓣复位良好，边缘整齐，瓣下干净。术后3天取出角膜接触镜，其中7眼视力≥1．0，2眼视力≥0．6。1月视力均达到最佳矫正视力，6月～1年视力稳定。结论LASIK手术中出现游离瓣只要及时正确处理，仍能获得最佳矫正视力。     

Appropriateness of hysterectomy in Taiwan.

BACKGROUND AND PURPOSE: Hysterectomy is among the most frequently performed surgical procedures in developed countries, but few studies from the Asia-Pacific region have assessed the appropriateness of hysterectomy. The purpose of this study was to examine the rate of inappropriate hysterectomy in Taiwan and its association with patient characteristics and indications for the procedure. METHODS: A random sample of hysterectomies for which claims were submitted to the Taiwan Bureau of National Health Insurance from July 1, 1997 to June 30, 1998 was selected. A total of 658 charts were reviewed by an expert panel composed of 5 senior gynecologists. RESULTS: Overall, 74.2% of patients underwent hysterectomy for appropriate reasons, 5.6% for uncertain reasons, and 20.2% for inappropriate reasons. Inappropriate procedures were positively associated with younger age and premenopausal status. Primary indications that accounted for over 25% of inappropriate procedures were chronic pelvic pain (42.9%), abnormal uterine bleeding (37.5%), and endometriosis (27.7%). CONCLUSIONS: This study found a high rate of inappropriate hysterectomy in Taiwan. Gynecologists and physician organizations should take action to improve physician agreement on the use of hysterectomy, especially for indications associated with high rates of inappropriate procedures.