Relationship of Iron Deposition to Calcium Deposition in Human Aortic Valve Leaflets

Background

Intraleaflet hematomas are associated with advanced stages of aortic valve calcification and suspected to be involved in disease progression. However, the mechanism by which the entry of blood cells into the valves affects the biology of aortic valvular interstitial cells (VICs) remains to be elucidated.

Vicarious growth among social work students: What makes the difference?

This study examined the contribution of background variables, personal factors (professional commitment) and environmental factors (peer support and supervision) to social work students' vicarious growth as an implication of their field practicums with trauma victims. Special emphasis was placed on examining the role of secondary traumatisation in the growth process. The sample consisted of 259 social work students at three social work schools in Israel. All students conducted their field practicums in social services and worked with trauma victims. The findings indicated that the mean level of growth was moderate and significant contribution was made by the student's year of study. Specifically, students in their third year of social work school showed more growth than did students in their first year. In addition, a positive contribution was made by the students’ supervision satisfaction, professional commitment and secondary traumatisation. The findings thus highlight the possibility of students' growth during their field practicums. In addition, the study emphasises the significant role played by supervisors in these practicums, in terms of both helping students grow as well as dealing with the distress they may feel during this part of their social work training.     

Metformin zur Behandlung des primär nicht insulinpflichtigen Diabetes mellitus bei adipösen Jugendlichen Bericht über 3 Fälle

Background. Metformin has proven efficacy in the treatment of obese adults with type-2 (non-insulin-dependent) diabetes mellitus. Case reports. We report in retrospect on three overweight adolescents with non-insulin-dependent diabetes mellitus, who were treated by hypocaloric diet plus metformin. During 10–14 months of follow -up, HbA1c transiently fell from 9.6–12.0% to 5.1–5.9%, while obesity persisted. In two patients (one with Prader-Willi-syndrome), body weight and HbA1c-levels increased again. Discussion. In summary, the cases provide further evidence for the efficacy of metformin in children and adolescents with non-insulin-dependent diabetes mellitus (e. g. type-2 diabetes). Caution,however, is required with this approach, as type-2 diabetes is the exception in childhood diabetes, and metformin should, therefore, be applied not as first-line treatment in childhood diabetes. Successful weight reduction appears to be of outmost importance for sustaining good metabolic control in obese adolescents with type-2 diabetes.     

Behçet's disease in obstetrics and gynecology

Beh?et's disease is a multisystemic disease of unknown origin characterized by a recurrent bipolar aphtosis (oral and genital) associated with vascular, digestive or articular symptoms. Gynecologists can be faced to this disease at any time of the life of their patients, including during the pregnancy. Given that the first demonstrations of the disease can be genital, they are in the front line to evoke this diagnosis. They thus have to know the main characteristics of the disease to make the diagnosis and to organize a multidisciplinary management. During pregnancy, the treatment of the disease is to be adapted to avoid teratogenic drugs, and adapt the doses of the treatment.     

Widespread distribution of disinfectant resistance genes among staphylococci of bovine and caprine origin in Norway

We demonstrate here a widespread distribution of genes mediating efflux-based resistance to quaternary ammonium compounds (QACs) in staphylococci from unpasteurized milk from 127 dairy cattle herds and 70 dairy goat herds. QAC resistance genes were identified in 21% of the cattle herds (qacA/B, smr, qacG, and qacJ) and in 10% of the goat herds (qacA/B and smr). Further examination of 42 QAC-resistant bovine and caprine isolates revealed the following genes: qacA/B (12 isolates) was present in four different species of coagulase-negative staphylococci (CoNS), smr (27 isolates) was detected in eight different CoNS species and in Staphylococcus aureus on a previously reported plasmid (pNVH99), qacG (two isolates) was detected on two plasmids (pST94-like) in Staphylococcus cohnii and Staphylococcus warneri, and qacJ (two isolates) was found in Staphylococcus hominis and Staphylococcus delphini on a plasmid (pNVH01) previously found in equine staphylococci. Isolation of indistinguishable pulsed-field gel electrophoresis (PFGE) CoNS types from tank milk and mammary quarter milk samples in a dairy cattle herd suggested that these QAC-resistant staphylococci were of intramammary origin. Indistinguishable or closely related PFGE types of bovine QAC-resistant CoNS were observed in different herds. One particular bovine S. warneri PFGE type was isolated repeatedly from samples collected during a 30-month period in a herd, showing long-term persistence. In conclusion, it seems that the widespread distribution of staphylococci carrying QAC resistance genes in Norwegian dairy cattle and goat herds is the result of both the intra- and interspecies spread of QAC resistance plasmids and the clonal spread of QAC-resistant strains.     

Exposure to terrorism and violent behavior among adolescents in Israel

It is commonly assumed that exposure to terrorism may lead to violent behavior, but there is little empirical research on the relationship between these two variables. In the present paper, we examined the extent to which exposure to terrorism contributes to violent behavior among adolescents. In addition, we considered the role of environmental factors ( domestic and community violence) and personal and environmental resources (family and social support, mastery, hope, and life satisfaction). Two hundred and fifty‐four Israeli adolescents residing in areas with different levels of exposure to terrorism completed questionnaires. The findings confirm that exposure to terrorism contributes significantly to violent behavior. Exposure to domestic and community violence and mastery also contributed to explaining the variance in violent behavior, whereas the effects of hope and life satisfaction were indirect, and were expressed only in an interaction with variables of exposure to terrorism. The findings may be helpful in identifying groups at risk for violent behavior, as well as in guiding professionals to moderate and prevent such behavior. The findings also emphasize the impact of security‐related stress situations and prolonged exposure to terrorism on manifestations of violence. © 2007 Wiley Periodicals, Inc.