全文获取类型
收费全文 | 21189篇 |
免费 | 1430篇 |
国内免费 | 83篇 |
专业分类
耳鼻咽喉 | 144篇 |
儿科学 | 670篇 |
妇产科学 | 498篇 |
基础医学 | 3357篇 |
口腔科学 | 400篇 |
临床医学 | 2094篇 |
内科学 | 4194篇 |
皮肤病学 | 461篇 |
神经病学 | 2250篇 |
特种医学 | 517篇 |
外科学 | 1933篇 |
综合类 | 118篇 |
一般理论 | 27篇 |
预防医学 | 2239篇 |
眼科学 | 369篇 |
药学 | 1241篇 |
中国医学 | 38篇 |
肿瘤学 | 2152篇 |
出版年
2023年 | 187篇 |
2022年 | 342篇 |
2021年 | 640篇 |
2020年 | 423篇 |
2019年 | 608篇 |
2018年 | 685篇 |
2017年 | 531篇 |
2016年 | 609篇 |
2015年 | 694篇 |
2014年 | 841篇 |
2013年 | 1183篇 |
2012年 | 1677篇 |
2011年 | 1666篇 |
2010年 | 948篇 |
2009年 | 842篇 |
2008年 | 1471篇 |
2007年 | 1409篇 |
2006年 | 1285篇 |
2005年 | 1240篇 |
2004年 | 1086篇 |
2003年 | 1111篇 |
2002年 | 966篇 |
2001年 | 133篇 |
2000年 | 83篇 |
1999年 | 121篇 |
1998年 | 182篇 |
1997年 | 152篇 |
1996年 | 122篇 |
1995年 | 123篇 |
1994年 | 103篇 |
1993年 | 101篇 |
1992年 | 55篇 |
1991年 | 68篇 |
1990年 | 50篇 |
1989年 | 46篇 |
1988年 | 26篇 |
1987年 | 43篇 |
1986年 | 47篇 |
1985年 | 55篇 |
1984年 | 54篇 |
1983年 | 47篇 |
1982年 | 72篇 |
1981年 | 54篇 |
1980年 | 45篇 |
1979年 | 38篇 |
1978年 | 35篇 |
1976年 | 30篇 |
1975年 | 26篇 |
1974年 | 33篇 |
1973年 | 28篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
31.
Barbara Schubert Cornelia S. Seitz Eva‐Bettina Brcker Henning Hamm 《Journal der Deutschen Dermatologischen Gesellschaft》2007,5(8):680-682
Childhood psoriasis is a disease with manifold clinical presentations which can make the correct diagnosis sometimes difficult. In a female infant, slightly itching, erythematous papules and plaques with discrete scaling spread over large parts of the integument starting from age three months. Histological examination supported the diagnosis of exanthematous infantile psoriasis. Topical treatment with dithranol in petrolatum led to slow clearance of the skin lesions. 相似文献
32.
Hans-Holger Capelle Johannes C W?hrle Ralf Weigel Hansj?rg B?zner Eva Grips Joachim K Krauss 《Movement disorders》2004,19(10):1202-1208
It is well known that brain injury or central traumatic lesions may result in the subsequent appearance of movement disorders such as dystonia or tremor. The concept that peripheral lesions to neural structures may be involved in the pathogenesis of movement disorders has been discussed controversely but has gained more widespread acceptance only recently. Here, we report on 6 patients who developed movement disorders after spinal disc surgery. The movement disorders became manifest with a delay of 1 day to 12 months after surgery. Of the six patients, 4 underwent cervical disc surgery, and 2 patients were operated on for lumbar disc herniation; 2 patients presented with paroxysmal kinesigenic segmental dystonia, 1 patient with focal dystonia, 2 with unilateral tremor, and 1 with bilateral tremor. The appearance of the movement disorder was associated with persistent dermatomal or segmental pain. In all patients, the anatomic distribution of the movement disorder was related to the nerve root or spinal segment of the corresponding disc level and the manifestation was in close temporal relation to the surgery. We conclude that spinal disc surgery may be another, thus far neglected, cause for movement disorders. The postoperative pain syndrome in all patients should be considered as an important factor of pathogenesis. Overall, movement disorders associated with disc surgery appear to be rare, yet they may cause significant discomfort to the affected individual. 相似文献
33.
34.
Amyloid fibril formation by human stefin B: influence of pH and TFE on fibril growth and morphology.
Eva Zerovnik Miha Skarabot Katja Skerget Silva Giannini Veronika Stoka Sasa Jenko-Kokalj Rosemary A Staniforth 《Amyloid》2007,14(3):237-247
As shown before, human stefin B (cystatin B) populates two partly unfolded species, a native-like state at pH 4.8 and a structured molten globule state at pH 3.3 (high ionic strength), from each of which amyloid fibrils grow. Here, we show that the fibrils obtained at pH 3.3 differ from those at pH 4.8 and that those obtained at pH 3.3 (protofibrils) do not transform readily to mature fibrils. In addition we show that amorphous aggregates are also a source of fibrils. The kinetics of amyloid fibril formation at different trifluoroethanol (TFE) concentrations were measured. TFE accelerates fibril growth at predenaturational concentrations of the alcohol. At concentrations higher than 10%, the fibrillar yield decreases proportionately as the population of an all alpha-helical, denatured form of the protein increases. At an optimum TFE concentration, the lag and the growth phases are observed, similarly to some other amyloidogenic proteins. Morphology of the protein species at the beginning and the end of the reactions was observed using atomic force microscopy and transmission electron microscopy. Final fibril morphologies differ depending on solvent conditions. 相似文献
35.
36.
37.
Effect of early and late antibiotic treatment in experimental acute pancreatitis in rats 总被引:1,自引:0,他引:1
Michael Schwarz Bertram Poch Rainer Isenmann Dietrich Kriese Eva Rozdzinski Hans G. Beger Frank Gansauge 《Langenbeck's archives of surgery / Deutsche Gesellschaft fur Chirurgie》2007,392(3):365-370
Background The clinical course in acute necrotizing pancreatitis is mainly determined by bacterial infection of pancreatic and peripancreatic
necrosis. The effect of two antibiotic regimens for early and late treatment was investigated in the taurocholate model of
necrotizing pancreatitis in the rat.
Materials and methods Seventy male Wistar rats were divided into five pancreatitis groups (12 animals each) and a sham-operated group (10 animals).
Pancreatitis was induced by intraductal infusion of 3% taurocholate under sterile conditions. Animals received two different
antibiotic regimes (20 mg/kg imipenem or 20 mg/kg ciprofloxacin plus 20 mg/kg metronidazole) early at 2, 12, 20, and 28 h
after induction of pancreatitis or late at 16 and 24 h after induction of pancreatitis or no antibiotics (control). Animals
were examined after 30 h for pancreatic and extrapancreatic infection.
Results Early and late antibiotic treatment with both regimes could significantly reduce pancreatic infection from 58 to 8–25%. However,
extrapancreatic infection was only reduced by early antibiotic therapy. While quinolones also reduced bacterial counts in
small and large bowel, imipenem did not.
Conclusions In our animal model of necrotizing pancreatitis, early and late treatment with ciprofloxacin/metronidazole and imipenem reduce
bacterial infection of the pancreas. Extrapancreatic infection, however, is reduced significantly only by early antibiotic
treatment. The effectivity of early antibiotic treatment in the clinical setting should be subject to further investigation
with improved study design and sufficient patient numbers. 相似文献
38.
One-year follow-up of patients with first-episode schizophrenia (comparison between remitters and non-remitters) 下载免费PDF全文
Eva ekov Pikryl Radovan Kaprek Tom Ku
erov Hana 《Neuropsychiatric Disease and Treatment》2007,3(1):153-160
Patients admitted to hospital after being diagnosed with first-episode schizophrenia were comprehensively assessed prior to acute treatment (on admission), at the end of the acute treatment (at discharge), and at follow-up after 1 year. The psychopathology was evaluated using the Positive and Negative Syndrome Scale (PANSS). 93 patients were reassessed after 1 year. 73/93 (78%) of the patients fulfilled the criteria for remission. No statistically significant differences in the total PANSS or subscales scores were found between remitters and non-remitters before or after the first episode treatment. However, non-remitters had a significantly higher total PANSS score after 1 year than remitters. There was no significant difference in mean psychopathology on admission or at discharge, with the exception of items conceptual disorganization, difficulty in abstract thinking, and lack of judgment and insight between remitters and non-remitters. However, significantly higher mean values were found for all items after 1 year in non-remitters than remitters. On admission the occurrence of positive, negative and general symptoms was balanced; at discharge and after 1 year negative and general symptoms were the most frequently observed. At the 1-year follow-up the impairment of insight and judgment is one of the most frequent symptoms in both remitters (10%) and non-remitters (70%). 相似文献
39.
Kevin W Eva 《Medical education》2009,43(12):1124-1124
40.