全文获取类型
收费全文 | 533篇 |
免费 | 15篇 |
国内免费 | 8篇 |
专业分类
耳鼻咽喉 | 2篇 |
儿科学 | 3篇 |
妇产科学 | 3篇 |
基础医学 | 45篇 |
口腔科学 | 3篇 |
临床医学 | 41篇 |
内科学 | 134篇 |
皮肤病学 | 6篇 |
神经病学 | 30篇 |
特种医学 | 78篇 |
外科学 | 123篇 |
综合类 | 1篇 |
预防医学 | 9篇 |
眼科学 | 13篇 |
药学 | 18篇 |
肿瘤学 | 47篇 |
出版年
2023年 | 3篇 |
2022年 | 19篇 |
2021年 | 38篇 |
2020年 | 10篇 |
2019年 | 11篇 |
2018年 | 5篇 |
2017年 | 5篇 |
2016年 | 10篇 |
2015年 | 12篇 |
2014年 | 13篇 |
2013年 | 17篇 |
2012年 | 17篇 |
2011年 | 36篇 |
2010年 | 24篇 |
2009年 | 10篇 |
2008年 | 31篇 |
2007年 | 21篇 |
2006年 | 22篇 |
2005年 | 20篇 |
2004年 | 24篇 |
2003年 | 23篇 |
2002年 | 14篇 |
2001年 | 11篇 |
2000年 | 12篇 |
1999年 | 8篇 |
1997年 | 6篇 |
1996年 | 6篇 |
1995年 | 3篇 |
1994年 | 5篇 |
1993年 | 2篇 |
1992年 | 16篇 |
1991年 | 6篇 |
1990年 | 5篇 |
1989年 | 8篇 |
1988年 | 5篇 |
1987年 | 4篇 |
1986年 | 12篇 |
1985年 | 7篇 |
1984年 | 4篇 |
1983年 | 3篇 |
1982年 | 4篇 |
1980年 | 2篇 |
1979年 | 6篇 |
1976年 | 3篇 |
1975年 | 4篇 |
1974年 | 5篇 |
1972年 | 9篇 |
1970年 | 3篇 |
1969年 | 3篇 |
1967年 | 2篇 |
排序方式: 共有556条查询结果,搜索用时 31 毫秒
61.
Pascu M Agafiţei GE Profire L Vasile C 《Revista medico-chirurgical?? a Societ????ii de Medici ??i Naturali??ti din Ia??i》2009,113(1):257-263
The behavior at degradation by soil burial of some plasticized polyvinyl chloride (PVC) based blends with a variable content of hydrolyzed collagen (HC) has been followed. MATERIAL AND METHOD: The modifications induced in the environment by the polymer systems (pH variation, physiologic state of the plants, assimilatory pigments) were studied. Using the growth test of the terrestrial plants, we followed the development of Triticum (wheat), Helianthus annus minimus (little sunflower), Pisum sativum (pea), and Vicia X hybrida hort, during a vegetation cycle. After the harvest, for each plant, the quantities of chlorophyll and carotenoidic pigments and of trace- and macroelements were determined. RESULTS: It was proved that, in the presence of polymer blends, the plants do not suffer morphological and physiological modifications, the products released in the culture soil being not toxic for the plants growth. 相似文献
62.
Vasile VC Chai HS Khambatta S Afessa B Jaffe AS 《The American journal of medicine》2010,123(11):1049-1058
Background
Elevations in cardiac troponin have prognostic importance in critically ill patients. However, there are no data addressing the independent association between troponin levels and mortality, adjusted for the severity of the underlying disease, in patients hospitalized for acute respiratory disorders. We investigated whether troponin T (cTnT) elevations are independently associated with in-hospital mortality in patients in the intensive care unit (ICU) admitted for severe and acute respiratory conditions. After adjusting for the severity of disease measured by the Acute Physiology, Age, and Chronic Health Evaluation (APACHE) III prognostic system, we evaluated short-term (30 days) and long-term (3 years) mortality.Methods
We studied the APACHE III database and cTnT levels from patients admitted consecutively to the ICU at Mayo Clinic, Rochester, Minnesota. Between January 2001 and December 2005, 2078 patients with respiratory conditions had cTnT measured at ICU admission. In-hospital, short-term (30 days) and long-term (3 years) all-cause mortality were determined.Results
Of the study patients, 878 (42.3%) had elevated cTnT and 1200 patients (57.7%) had undetectable cTnT. During hospitalization, 1.1% of the patients with troponin T <0.01 ng/mL died compared to 21% of those with troponin T ≥0.01 ng/mL (P <.0001). At 30 days, mortality was 18.6% in patients with elevations of cTnT and 1.5% in patients without elevations of cTnT (P <.0001). The Kaplan-Meier probability of survival at 1-year follow-up was 71.0%, at 2-year follow-up was 48.3%, and 3-year follow-up was 39.4% with troponin T ≥0.01 ng/mL and at 1-year follow-up was 98.8%, at 2-year follow-up was 97.2%, and at 3-year follow-up was 95.5% with troponin T <0.01 μg/L (P <.0001). After adjustment for severity of disease and baseline characteristics, cTnT levels remained associated with in-hospital, short-term and long-term mortality (P <.0001).Conclusions
In patients admitted to the ICU for respiratory disorders, cTnT elevations are independently associated with in-hospital, short-term and long-term mortality. 相似文献63.
64.
Silecchia G Boru CE Mouiel J Rossi M Anselmino M Morino M Toppino M Gaspari A Gentileschi P Tacchino R Basso N 《Surgical endoscopy》2008,22(11):2492-2497
Background
Published interim results have shown that fibrin sealant (Tissucol®/Tisseel® Baxter AG, Vienna, Austria) may be effective in preventing anastomotic leaks and internal hernias following laparoscopic Roux-en-Y gastric bypass (LRYGBP). We report the final results of a multicenter, randomized clinical trial evaluating the use of fibrin sealant in LRYGBP.Methods
Between January 2004 and December 2005, 340 patients aged 21–65 years with a body mass index (BMI) of 40–59 kg/m2 undergoing LRYGBP were randomized (1:1) to two treatment groups: fibrin sealant group (applied to gastrojejunal and jejunojejunal anastomoses and over mesenteric openings), and control group (no fibrin sealant; suture of the mesenteric openings). Operative time, early and late complications, reinterventions, time to oral diet initiation, and length of stay were assessed.Results
Overall, 320 patients were included into the study: 160 in the control group and 160 in the fibrin sealant group. All patients completed follow-up assessments at 6 and 12 months, and 60.9% completed assessments at 24 months. There were no significant differences between groups with respect to demographics, operative time, oral diet initiation, hospital stay, and BMI reduction at 6, 12, and 24 months. The incidence of anastomotic leak was numerically, but not significantly, greater in the control group. The overall reintervention rate for specific early complications (<30 days) was significantly higher in the control group (p = 0.016). No deaths or conversions to open laparotomy occurred.Conclusion
The use of fibrin sealant in laparoscopic RYGBP may be beneficial in reducing the reintervention rate for major perioperative (<30 days) complications. Larger studies are needed. 相似文献65.
66.
Blaga R Durand B Antoniu S Gherman C Cretu CM Cozma V Boireau P 《The American journal of tropical medicine and hygiene》2007,76(5):983-986
According to the International Commission on Trichinellosis survey in 2004, Romania has the most cases of trichinellosis in the world. Epidemiologic data for each county were collected and analyzed from two different time periods: before (1980-1989) and after (1990-2004) political changes. Data were analyzed separately for Transylvania and the rest of the Romanian counties. During the past 25 years, 28,293 human cases of trichinellosis were reported with an incidence of 51.0 cases per 10(6) persons per year. An important increase in the incidence was observed from 1980 to 1989 compared with the 1990-2004 period. For the entire period, the incidence rate obtained for Transylvanian counties (82.2 cases per 10(6) persons per year) was higher than the incidence rate obtained for the other counties (35.7 cases per 10(6) persons per year). Hypotheses and facts contributing to the heterogeneity of human trichinellosis cases are discussed. 相似文献
67.
Vasile D Grigoriu M Turcu F Ilco A Tenovici G Vasile R 《Chirurgia (Bucharest, Romania : 1990)》2007,102(1):83-87
Pancreas divisum (P.D.) is a congenital anatomic variant, characterized by the nonunion of dorsal and ventral pancreatic ducts. A 20 years old man followed for 8 years with reccurent abdominal pain and relapsing acute pancreatitis develope chronic calcific pancreatitis. He was diagnosed with P.D. on endoscopic retrograde pancreatography and operative pancreatography. The patient was treated with longitudinal pancreatico-jejunostomy (PUESTOW-GILLESBY procedure). His pain resolved following surgical drainage of the pancreatic duct. Evaluation of the clinical course of this patient and critical review of other such cases in the literature support the role of compromised ductal drainage of the pancreas in the pathogenesis of chronic pancreatitis in P.D. 相似文献
68.
Blanchon T Bréchot JM Grenier PA Ferretti GR Lemarié E Milleron B Chagué D Laurent F Martinet Y Beigelman-Aubry C Blanchon F Revel MP Friard S Rémy-Jardin M Vasile M Santelmo N Lecalier A Lefébure P Moro-Sibilot D Breton JL Carette MF Brambilla C Fournel F Kieffer A Frija G Flahault A;Dépiscan Group 《Lung cancer (Amsterdam, Netherlands)》2007,58(1):50-58
BACKGROUND: Lung cancer has the highest mortality-rate per cancer, with an overall 5-year survival <15%. Several non-randomized studies pointed out the high sensitivity of low dose computed tomography (LDCT) to detect early stage lung cancer. In France, Depiscan, a pilot RCT of LDCT versus chest X-ray (CXR), started on October 2002 to determine the feasibility of enrollment by general practitioners (GPs), investigations and diagnostic procedures by university hospital radiologists and multidisciplinary teams, data management by centralized clinical research assistants, and anticipate the future management of a large national trial. METHODS: GPs and occupational physicians (OPs) selected and enrolled 1000 subjects in 1 year. Eligible subjects were asymptomatic males or females aged 50-75 years with a current or former cigarette smoking history of >/=15 cigarettes per day for at least 20 years (former smokers having quit <15 years prior to enrollment). Based to randomization, annual LDCT or CXR screenings were planned at baseline and annually for 2 years. RESULTS: Between October 2002 and December 2004, 765 subjects were enrolled by 89 out of the 232 participating GPs and OPs. Complete clinical and imaging baseline data were available for 621 individuals out of the 765 enrolled, due to 144 noncompliant subjects who withdrew their consent. At least one nodule was detected in 152 out of 336 subjects (45.2%) in the LDCT screening, versus 21 out of 285 subjects (7.4%) in the CXR screening arm. Eight lung cancers were detected in the LDCT arm and one in the CXR arm. DISCUSSION: This pilot trial allows estimating that non-calcified nodules are 10 [6.36-17.07] times more often detected from LDCT than from CXR. However enrollment by GPs was more difficult than expected with 41% active investigators and a high rate (19%) of noncompliant patients. This experience speaks to the need for a high level of GPs formation and a large, coordinated clinical research team in such a trial. Trial registration number: 02526. 相似文献
69.
70.
Achraf Al Faraj Ghislaine Lacroix Hasan Alsaid Dan Elgrabi Vasile Stupar Franck Robidel Sophie Gaillard Emmanuelle Canet-Soulas Yannick Crémillieux 《Magnetic resonance in medicine》2008,59(6):1298-1303
Epidemiological and toxicological studies have provided evidence that accidentally inhaled nanosize ultrafine particles can induce chronic or acute health damage. MRI, being noninvasive, is able to assess the biodistribution and clearance of magnetically labeled nanoparticles induced by instillation or inhalation. We report 3He and proton MRI follow-up of lung, liver, spleen, and kidney distribution of USPIO (ultrasmall superparamagnetic iron oxide) in a rat model. The sensitivity of the imaging technique to various concentrations of instilled magnetite suspension was first assessed in vivo (n=12). A 2-week longitudinal imaging study was then performed on animals (n=7) instilled with a 0.5 mg magnetite solution. Hypointense and void signal regions associated with intrapulmonary USPIO were observed in the 3He ventilation images throughout the study, whereas no USPIO-related proton signal intensity changes were found. Intrapulmonary magnetite nanoparticle confinement was confirmed by ex vivo iron assay and histological analysis. This study demonstrates that combined 3He and proton MRI enables noninvasive assessment of the distribution and clearance of magnetically labeled instilled nanoparticles. 相似文献