全文获取类型
收费全文 | 874篇 |
免费 | 161篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 12篇 |
儿科学 | 46篇 |
妇产科学 | 9篇 |
基础医学 | 32篇 |
口腔科学 | 10篇 |
临床医学 | 150篇 |
内科学 | 248篇 |
皮肤病学 | 29篇 |
神经病学 | 43篇 |
特种医学 | 76篇 |
外科学 | 173篇 |
综合类 | 48篇 |
现状与发展 | 20篇 |
预防医学 | 60篇 |
眼科学 | 25篇 |
药学 | 18篇 |
中国医学 | 7篇 |
肿瘤学 | 46篇 |
出版年
2024年 | 7篇 |
2023年 | 42篇 |
2021年 | 17篇 |
2020年 | 22篇 |
2019年 | 9篇 |
2018年 | 49篇 |
2017年 | 44篇 |
2016年 | 31篇 |
2015年 | 40篇 |
2014年 | 39篇 |
2013年 | 56篇 |
2012年 | 18篇 |
2011年 | 26篇 |
2010年 | 47篇 |
2009年 | 63篇 |
2008年 | 32篇 |
2007年 | 26篇 |
2006年 | 25篇 |
2005年 | 16篇 |
2004年 | 12篇 |
2003年 | 15篇 |
2002年 | 12篇 |
2001年 | 17篇 |
2000年 | 11篇 |
1999年 | 21篇 |
1998年 | 28篇 |
1997年 | 32篇 |
1996年 | 43篇 |
1995年 | 29篇 |
1994年 | 17篇 |
1993年 | 21篇 |
1992年 | 8篇 |
1991年 | 8篇 |
1990年 | 10篇 |
1989年 | 15篇 |
1988年 | 17篇 |
1987年 | 14篇 |
1986年 | 12篇 |
1985年 | 12篇 |
1984年 | 4篇 |
1983年 | 6篇 |
1982年 | 8篇 |
1981年 | 4篇 |
1980年 | 5篇 |
1978年 | 12篇 |
1977年 | 8篇 |
1976年 | 7篇 |
1975年 | 5篇 |
1964年 | 5篇 |
1963年 | 4篇 |
排序方式: 共有1052条查询结果,搜索用时 0 毫秒
91.
Ruilang Lin BS Wen Feng PhD Yating Yang PhD Jiaqin Xu PhD Hui Yang BM Jingyi Wu BS Jiong Li PhD Guoyou Qin PhD Yongfu Yu PhD Jiaohua Chen PhD 《Journal of clinical hypertension (Greenwich, Conn.)》2023,25(5):480-488
Association between calcium intake and premature mortality in the general population has been well studied, but little is known about the association among specific populations. The authors aim to evaluate the association among people with hypertension and to provide a proper reference range of dietary calcium intake. This prospective cohort study included 8534 US adults with hypertension from National Health and Nutrition Examination Survey cycles 2003–2014. Dietary calcium intakes were self-reported and mortality status was ascertained by National Death Index records. During a median follow-up of 5.9 years, 1357 death occurred. Compared with participants of dietary calcium intake in quintile 1, participants in quintiles 2 and 4 had a 27% (HR: 0.73, 95% CI: 0.60–0.89) and a 29% lower risk (HR: 0.71, 95% CI: 0.57–0.88) of all-cause mortality respectively. The authors also observed a 34% lower risk (HR: 0.66, 95% CI: 0.45–0.97) of CVD death among participants in quintile 3 and a 37% lower risk (HR: 0.63, 95% CI: 0.40–0.99) of cancer-related death in participants in quintile 4 respectively. Restricted cubic spline (RCS) regression revealed a consistent protective effect of dietary calcium in participants with a daily intake of over 1000 mg, but a daily intake over 1200 mg fails to show further protective effect. Our findings suggest that elevated dietary calcium was associated with lower mortality risk from all-causes, cardiovascular disease (CVD) and cancer, and supplying sufficient dietary calcium intake, between 1000 and 1200 mg per day, in people with hypertension may be considered cost-effective to decrease risk of premature death. 相似文献
92.
Baohua Zhu MD Chengjiang Liu MD Ph.D Lan Zhang MD Jun Wang MS Mingling Chen MD Yuegang Wei BM 《Journal of Cosmetic Dermatology》2023,22(3):1083-1098
Background
Vitiligo was an autoimmune disease and some guidelines for the management of vitiligo encouraged the use of NB-UVB combination therapies to enhance repigmentation.Objectives
To compare the effectiveness of current NB-UVB combination regimen at the improvement in repigmentation through a systematic review and network meta-analysis.Methods
We searched the electronic databases for randomized controlled trials related to NB-UVB combination therapy for vitiligo till October 2022. STATA15.0 software was applied to carrying out data analysis.Results
A total of 28 eligible studies involving 1194 participants were enrolled in the analysis. The NMA results revealed that compared with NB-UVB, carboxytherapy [OR = 32.35, 95% CI (1.79, 586.05)], Er: YAG laser+ topical 5% 5-FU [OR = 10.74, 95% CI (4.05, 28.49)], needling/micro-needling [OR = 3.42, 95% CI (1.18, 9.88)], betamethasone intramuscular injection [OR = 3.08, 95% CI (1.17, 8.13)], topical tacrolimus [OR = 2.54, 95% CI (1.30, 4.94)], and oral Chinese herbal medicine compound [OR = 2.51, 95% CI (1.40, 4.50)] integrated with NB-UVB were more efficacious in excellent to complete repigmentation response rate (≥75%). Besides, NB-UVB+ Er: YAG laser+ topical 5% 5-FU [OR = 0.17, 95% CI (0.04, 0.67)] and NB-UVB+ needling/micro-needling [OR = 0.24, 95% CI (0.06, 0.88)] were less likely evaluated as ineffective repigmentation response (≤25%).Conclusions
All combination therapies ranked higher than NB-UVB monotherapy in inducing successful repigmentation and avoiding failed treatment in patients with vitiligo. Comprehensive consideration, NB-UVB+ Er: YAG laser+ topical 5% 5-FU and NB-UVB+ needling/microneedling would be the preferred therapeutic approaches. 相似文献93.
A. J. Vipond BM MRCP Senior House Officer in Medicines S. Bakewell MB ChB Registrar in Anaesthetics R. Telford BSc FRCA Consultant Anaesthetist A. J. Nicholls MB FRCP Consultant Renal Physician 《Anaesthesia》1996,51(12):1156-1158
We report a case of severe lithium toxicity precipitated by a thiazide diuretic and compounded by an angiotensin converting enzyme inhibitor. There was severe vasodilatation refractory to noradrenaline. 相似文献
94.
Opposite effects of a glucokinase activator and metformin on glucose‐regulated gene expression in hepatocytes 下载免费PDF全文
95.
Until recently, axillary node clearance had long been the standard of care in patients with axillary node-positive disease. One stop nucleic acid sampling (OSNA) has been used to guide intraoperative decision-making regarding suitability for axillary node clearance (ANC). The aim of this study is to evaluate the use of OSNA following neoadjuvant chemotherapy (NACT) and whether it can predict lymph node burden in ANC. A single center, prospective cohort study was performed on 297 patients having OSNA between 2016 and 2019. Patients were sub-classified according to node positivity at diagnosis and those treated with NACT and outcomes included copy number and lymph node harvest. Axillary complete pathological response was observed in 24/36 patients (67%) following NACT. 14/16 patients (87%) having axillary node clearance had axillary node disease limited to 4 nodes. OSNA copy numbers were significantly higher in patients showing disease progression following NACT. Overall, 73% of patients with lymph node positivity at diagnosis could be successfully treated with a combination of NACT and lymph node excision of four nodes. De-escalating axillary surgical treatment to resection of four nodes following NACT may be effective in balancing oncological resection and limiting treatment morbidity. ONSA can correctly identify patients experiencing disease progression who would benefit from traditional three-level ANC. 相似文献
96.
A randomized controlled trial of sedation in the critically ill 总被引:2,自引:0,他引:2
LYNN PARKINSON RSCN JULIE HUGHES RSCN REA GILL MSc IMOGEN BILLINGHAM BM FRCA JANE RATCLIFFE MB ChB FRCP & IMTI CHOONARA MD MRCP 《Paediatric anaesthesia》1997,7(5):405-510
A randomized controlled trial comparing: a) a combination of oral chloral hydrate and promethazine to b) a continuous intravenous midazolam infusion, for maintenance sedation in critically ill children, was carried out. The level of sedation was assessed four hourly using a specifically devized sedation scale. Forty-four children entered the study of whom two were subsequently excluded. The number of satisfactory assessments (desired and actual levels of sedation equal) was significantly greater in the chloral hydrate and promethazine group (Chi-squared P <0.01; confidence intervals of the difference 0.06 to 0.20). The number of assessments at level 5 on the sedation scale (patient restless/distressed) was significantly greater in the midazolam group (Chi-squared P <0.05). The total number of satisfactory assessments in the two groups were only 61 and 48% respectively, suggesting that sedation can be considerably improved. Chloral hydrate and promethazine are more effective than midazolam as maintenance sedation in critically ill children. It is possible to prospectively study the efficacy of sedative drugs in critically ill children. 相似文献
97.
Objectives
Facial lipoatrophy can be a stigmatizing side effect of antiretroviral (AVR) treatment for HIV‐infected patients. We sought to evaluate the long‐term efficacy and safety of a new formulation of hyaluronic acid that can be injected in larger amounts and into deeper skin layers during 3 years of follow‐up.Methods
Twenty patients received injections of Restylane SubQ™. Refill treatment was offered at 12 and 24 months. Treatment effects were evaluated using ultrasound, the Global Aesthetic Improvement Scale, visual analogue scale (VAS) and the Rosenberg self‐esteem scale.Results
Seventeen patients remained at 36 months. Mean (± standard deviation) total cutaneous thickness increased from 6 ± 1 mm at baseline to 12 ± 1 mm (P<0.001) at 36 months. Response rate (total cutaneous thickness >10 mm) was 70%. Fifteen patients classified their facial appearance as very much or moderately improved. VAS increased from 39 ± 25 to 70 ± 20 (P<0.05) and higher self‐esteem scores were reported. Local swelling and tenderness after treatment was common. Persistent papules found in several patients after treatment were removed effectively with hyaluronidase injections. Three patients, treated only at baseline, still had higher total cutaneous thickness scores at 36 months.Conclusions
Our results indicate that a large particle hyaluronic acid formulation is a durable and well‐tolerated dermal filler for treating HIV‐positive patients with facial lipoatrophy.98.
99.
100.