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51.
Tomomasa Tochio Katsumi Mukai Youichirou Baba Hiroki Asakawa Kenji Nose Satomi Tsuruga Hiroaki Kumazawa Yoshiaki Isono Hiroki Tanaka Shimpei Matsusaki Tomohiro Sase Tomonori Saito Hiroshi Okano Miki Usui Gen Watanabe 《Clinical journal of gastroenterology》2018,11(6):465-469
Primary clear cell adenocarcinoma (CCA) of the colorectum is a rare tumor. We report on a 48-year-old man with early stage CCA in the descending colon who underwent detailed examination with image-enhanced endoscopy, such as magnifying endoscopy with narrow-band imaging and crystal violet staining. The tumor was treated successfully with endoscopic mucosal resection at our hospital. 相似文献
52.
Shigetsuna Komatsu Masaru Honma Satomi Igawa Hitomi Tsuji Akemi Ishida‐Yamamoto Kiyoshi Migita Hiroaki Ida Hajime Iizuka 《The Journal of dermatology》2014,41(9):827-829
Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory disease, which is characterized by recurrent and paroxysmal fever, peritonitis, arthritis, myalgia, and skin rashes. Although various skin lesions such as “erysipelas‐like erythema”, urticaria, nonspecific purpura, and subcutaneous nodules have been described, cutaneous vasculitis is rare. We report a Japanese case of sporadic FMF accompanied by cutaneous arteritis at the time of febrile attacks of FMF. Gene analysis revealed M694I mutation in a single allele of the MEFV gene, and oral colchicine successfully controlled both periodic fever and subcutaneous nodules of arteritis. Cutaneous necrotizing vasculitis repeatedly emerging with febrile attacks should be included among the skin manifestations of FMF. 相似文献
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54.
Rie Fukui Eriko Tanabe Misaho Kitayoshi Kyohei Yoshikawa Nobuyuki Fukushima Toshifumi Tsujiuchi 《Tumour biology》2012,33(6):1899-1905
Lysophosphatidic acid (LPA) mediates a wide range of biological responses with G protein-coupled transmembrane receptors (LPA receptors). So far, at least six types of LPA receptors (LPA receptor-1 (LPA1) to LPA6) have been identified. Recently, it has been reported that LPA3 indicates opposite effects on cellular functions of cancer cells. In the present study, to assess a biological role of LPA3 on cell migration ability of colon cancer cells, we generated LPA receptor-3 (LPAR3) knockdown (HCT-sh3-3) cells from HCT116 and measured cell motile and invasion activities. In motility assay with a cell culture insert, HCT-sh3-3 cells showed significantly high cell motile activity, compared with control cells. For invasion assay, the filter was coated with Matrigel. The invasive activity of HCT-sh3-3 cells was significantly higher than that of control cells. Furthermore, we also examined the effects of LPAR3 knockdown on the interaction between colon cancer cells and endothelial F-2 cells. When F-2 cells were cultured with serum-free DMEM containing a supernatant from HCT-sh3-3 cells, the cell growth rate and migration activity of F-2 cells were significantly stimulated, associating with the elevated expressions of vascular endothelial growth factor (VEGF)-A and VEGF-C genes in HCT-sh3-3 cells. These results suggest that LPA3 may act as a negative regulator on cell motile and invasive abilities of colon cancer HCT116 cells. 相似文献
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56.
Shigeo Hayashi Katsuyo Ohashi Eriko Nakata Chie Emoto 《Medicinal chemistry research》2014,23(1):526-552
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58.
Koji Takahashi Osamu Tanaka Yosuke Kudo Eriko Sugawara 《Neuro-ophthalmology (Aeolus Press)》2013,37(5):284-288
In eye movement examination, video-oculographic monocular recording has become more popular than electro-oculographic binocular recording. The aim of this study was to examine the characteristics of monocular movements recorded using video-oculography. In 66 healthy subjects, the horizontal saccades and smooth pursuit eye movements of the right eye within a range of 30º were evaluated using a video-oculographic eye movement recording system. Saccade latency, velocity, accuracy, and smooth pursuit gain were measured and analysed by age and direction. Saccade parameters (latency, velocity, and amplitude) and smooth pursuit gain deteriorated with age in healthy subjects. Saccade velocity and accuracy were significantly larger during adduction than during abduction. The smooth pursuit gain did not differ between adduction and abduction. In conclusion, unlike smooth pursuit eye movements, saccadic eye movements have adduction-abduction asymmetry. In video-oculographic monocular recording of saccades, it is necessary to recognise the possibility of the existence of adduction-abduction asymmetry. 相似文献
59.
Masaki Y Sumiyoshi M Suwa S Ohta H Matsunaga E Tamura H Takaya N Mineda Y Kojima S Nakata Y 《International heart journal》2005,46(2):323-326
Dissection of the sinus of Valsalva is an extremely rare accident during percutaneous coronary intervention (PCI), but it can lead to serious complications such as dissection of the ascending aorta. We experienced a localized dissection of the right coronary cusp without coronary artery involvement that was induced by a guiding catheter during PCI in a patient with acute myocardial infarction. The localized dissection showed pooling of the contrast medium in the acute phase, but it subsided spontaneously after 12 days without any sequelae. Manipulation of the guiding catheter should be performed with great caution not only in the coronary artery but also in the sinus of Valsalva. 相似文献
60.
Shinohara K Adachi M Matsui K Matsuda K Nagaya S Morishita E 《International journal of hematology》2008,87(3):256-259
The patient, a 20-year-old male, was found to have a slightly prolonged prothrombin time (PT). No episodes of bleeding were
noted. The measurement of coagulation factors revealed that the level of factor X (FX) activity was solely deficient, 51%
(normal range: 70–130% ), and that of FX antigen was 100%. Analysis of the entire FX gene revealed the novel missense mutation
of GTG to ATG, resulting in the substitution of the 196th amino acid valine → methionine. The mother and younger brother had a normal
PT time and expressed no episode of bleeding. The mother exhibited a normal level of FX activity and antigen; however the
younger brother showed a slight decrease in both the parameters. This mutation was not observed in the mother and younger
brother. Polymorphism is not observed at this point in healthy persons. The present novel FX mutation was named FX Hofu. 相似文献