全文获取类型
收费全文 | 521篇 |
免费 | 40篇 |
专业分类
耳鼻咽喉 | 35篇 |
儿科学 | 4篇 |
妇产科学 | 8篇 |
基础医学 | 64篇 |
口腔科学 | 28篇 |
临床医学 | 35篇 |
内科学 | 141篇 |
皮肤病学 | 3篇 |
神经病学 | 42篇 |
特种医学 | 14篇 |
外科学 | 62篇 |
综合类 | 6篇 |
预防医学 | 28篇 |
眼科学 | 5篇 |
药学 | 19篇 |
中国医学 | 6篇 |
肿瘤学 | 61篇 |
出版年
2022年 | 3篇 |
2021年 | 18篇 |
2020年 | 7篇 |
2019年 | 9篇 |
2018年 | 16篇 |
2017年 | 8篇 |
2016年 | 14篇 |
2015年 | 19篇 |
2014年 | 18篇 |
2013年 | 25篇 |
2012年 | 29篇 |
2011年 | 28篇 |
2010年 | 13篇 |
2009年 | 13篇 |
2008年 | 23篇 |
2007年 | 28篇 |
2006年 | 35篇 |
2005年 | 26篇 |
2004年 | 44篇 |
2003年 | 23篇 |
2002年 | 25篇 |
2001年 | 5篇 |
2000年 | 4篇 |
1998年 | 6篇 |
1997年 | 5篇 |
1995年 | 6篇 |
1994年 | 6篇 |
1992年 | 7篇 |
1991年 | 5篇 |
1990年 | 3篇 |
1989年 | 3篇 |
1988年 | 5篇 |
1987年 | 4篇 |
1986年 | 3篇 |
1985年 | 3篇 |
1984年 | 4篇 |
1982年 | 4篇 |
1981年 | 4篇 |
1980年 | 4篇 |
1977年 | 4篇 |
1976年 | 3篇 |
1975年 | 5篇 |
1974年 | 3篇 |
1973年 | 4篇 |
1970年 | 4篇 |
1964年 | 2篇 |
1960年 | 3篇 |
1940年 | 2篇 |
1924年 | 2篇 |
1902年 | 2篇 |
排序方式: 共有561条查询结果,搜索用时 15 毫秒
101.
Microvesicles in Health and Disease 总被引:1,自引:0,他引:1
Inal JM Ansa-Addo EA Stratton D Kholia S Antwi-Baffour SS Jorfi S Lange S 《Archivum immunologiae et therapiae experimentalis》2012,60(2):107-121
Microvesicles (or MVs) are plasma membrane-derived vesicles released from most eukaryotic cells constitutively during early
apoptosis or at higher levels after chemical or physical stress conditions. This review looks at some of the functions of
MVs in terms of intercellular communication and ensuant signal transduction, including the transport of proteins (unconventional
protein export) as well as of mRNA and microRNA. MVs also have roles in membrane repair, the removal of misfolded proteins,
and in the control of apoptosis. We also discuss the role MVs have been shown to have in invasive growth and metastasis as
well as in hypoxia in tumours and cerebral ischaemia. The association of MVs in infectious and autoimmune disease is also
summarised together with their possible use as therapeutic agents. 相似文献
102.
Dr. A. Ephraim 《European archives of oto-rhino-laryngology》1902,54(3-4):244-248
Ohne Zusammenfassung 相似文献
103.
Ohad Cohen Sigal Shaklai Ephraim Gabis Michael A. Pani 《Journal of diabetes science and technology》2008,2(5):890-895
Objective
We assessed the accuracy of the FreeStyle Mini™ (FSM) meter for use in glycemic clamp and meal protocols in comparison with the HemoCue Glucose 201 DM Analyzer (HemoCue) and the YSI 2300 STAT Glucose Oxidase Analyzer (YSI).Methods
Seven volunteers with type 2 diabetes mellitus, 35–69 years old, underwent a frequently sampled meal test and a graded hyperglycemic test, on two separate days, with one of the volunteers undergoing each test twice. Samples for glucose measurements were obtained from arterialized venous blood. A total of 420 samples (with glucose levels ranging from 63 to 388 mg/dl) were available for comparison. On average, 10 measurements were available for every 5 mg/dl increment in glucose level in the range of 130–310 mg/dl. Blood glucose measurements were done on each sample with the FSM, HemoCue, and YSI.Results
FreeStyle Mini blood glucose values correlated closely with the YSI readings. Of the FSM measurements, 99.0% were within the Clarke error grid zone A; 51.3%, 84.7%, and 96.2% of the FSM readings were within 5%, 10% and 15% of the YSI values, respectively. The FSM was significantly more accurate than the HemoCue (84.7% vs 76.6% of results within 10% of the YSI results; p = .0038). The mean average relative difference of the FSM (5.8%) was also significantly lower than that of the HemoCue (6.8%; p = .0013)Conclusions
The FSM provides accurate results and constitutes a suitable alternative for bedside blood glucose measurements in experimental procedures, helping to reduce sample size, turnaround time, and cost. 相似文献104.
105.
106.
Christoph Kaiser Tom Rubaale Ephraim Tukesiga Walter Kipp George Asaba 《The American journal of tropical medicine and hygiene》2015,93(1):198-202
Nodding syndrome (NS) is a poorly understood condition, which was delineated in 2008 as a new epilepsy syndrome. So far, confirmed cases of NS have been observed in three circumscribed African areas: southern Tanzania, southern Sudan, and northern Uganda. Case–control studies have provided evidence of an association between NS and infection with Onchocerca volvulus, but the causation of NS is still not fully clarified. We report a case of a 15-year old boy with head nodding seizures and other characteristic features of NS from an onchocerciasis endemic area in western Uganda, with no contiguity to the hitherto known areas. We suggest that the existence of NS should be systematically investigated in other areas. 相似文献
107.
108.
A novel rapid single nucleotide polymorphism (SNP)-based method for assessment of hematopoietic chimerism after allogeneic stem cell transplantation 总被引:5,自引:2,他引:5 下载免费PDF全文
Hochberg EP Miklos DB Neuberg D Eichner DA McLaughlin SF Mattes-Ritz A Alyea EP Antin JH Soiffer RJ Ritz J 《Blood》2003,101(1):363-369
A major end point of nonmyeloablative hematopoietic stem cell transplantation is the attainment of either mixed chimerism or full donor hematopoiesis. Because the majority of human genetic disparity is generated by single nucleotide polymorphisms (SNPs), direct measurement of SNPs should provide a robust tool for the detection and quantitation of chimerism. Using pyrosequencing, a rapid quantitative sequencing technology, we developed a SNP-based assay for hematopoietic chimerism. Based on 14 SNPs with high allele frequencies, we were able to identify at least 1 informative SNP locus in 55 patients with HLA-identical donors. The median number of informative SNPs in related pairs was 5 and in unrelated pairs was 8 (P <.0001). Assessment of hematopoietic chimerism in posttransplantation DNA was shown to be quantitative, accurate, and highly reproducible. The presence of 5% donor cells was reliably detected in replicate assays. Compared with current measures of engraftment based on identification of short tandem repeats (STRs), variable number of tandem repeats (VNTRs), or microsatellite polymorphisms, this SNP-based method provides a more rapid and quantitative assessment of chimerism. A large panel of SNPs enhances the ability to identify an informative marker in almost all patient/donor pairs and also facilitates the simultaneous use of multiple markers to improve the statistical validity of chimerism measurements. The inclusion of SNPs that encode minor histocompatibility antigens or other genetic polymorphisms that may influence graft-versus-host disease or other transplantation outcomes can provide additional clinically relevant data. SNP-based assessment of chimerism is a promising technique that will assist in the analysis of outcomes following transplantation. 相似文献
109.
110.