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Pulsed versus continuous wave CO2 laser excisions of 100 oral fibrous hyperplasias: A randomized controlled clinical and histopathological study 下载免费PDF全文
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Anne Raben PhD Pia Siig Vestentoft PhD Jennie Brand-Miller PhD Elli Jalo MSc Mathjis Drummen PhD Liz Simpson PhD J. Alfredo Martinez PhD Teodora Handjieva-Darlenska PhD Gareth Stratton PhD Maija Huttunen-Lenz PhD Tony Lam MBA Jouko Sundvall MSc Roslyn Muirhead PhD Sally Poppitt PhD Christian Ritz PhD Kirsi H. Pietiläinen PhD Margriet Westerterp-Plantenga PhD Moira A. Taylor PhD Santiago Navas-Carretero PhD Svetoslav Handjiev PhD Melitta A. McNarry PhD Sylvia Hansen MSc Laura Råman BSc Shannon Brodie MSc Marta P. Silvestre PhD Tanja C. Adam PhD Ian A. Macdonald PhD Rodrigo San-Cristobal PhD Nadka Boyadjieva PhD Kelly A. Mackintosh PhD Wolfgang Schlicht PhD Amy Liu PhD Thomas M. Larsen PhD Mikael Fogelholm DSc 《Diabetes, obesity & metabolism》2021,23(2):324-337
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Eoin O'Brien William B. White Gianfranco Parati Eamon Dolan 《Journal of clinical hypertension (Greenwich, Conn.)》2018,20(7):1108
In clinical practice, ambulatory blood pressure monitoring (ABPM) tends to be used solely for diagnosing hypertension, especially to identify white‐coat and masked hypertension. However, ABPM can provide additional information to guide the management and drug treatment of hypertension. In this brief review, the general principles governing the use of ABPM in clinical practice, such as the devices and software, recording requirements, the thresholds for the day, night and 24‐hour periods and how often to repeat ABPM are summarized. The use of ABPM for diagnosing, determining the efficacy of treatment, and assessing the long‐term control of hypertension are discussed. 相似文献
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Characterization of a mutation in a family with saposin B deficiency: a glycosylation site defect. 总被引:7,自引:0,他引:7 下载免费PDF全文
K A Kretz G S Carson S Morimoto Y Kishimoto A L Fluharty J S O''Brien 《Proceedings of the National Academy of Sciences of the United States of America》1990,87(7):2541-2544
Saposins are small, heat-stable glycoproteins required for the hydrolysis of sphingolipids by specific lysosomal hydrolases. Saposins A, B, C, and D are derived by proteolytic processing from a single precursor protein named prosaposin. Saposin B, previously known as SAP-1 and sulfatide activator, stimulates the hydrolysis of a wide variety of substrates including cerebroside sulfate, GM1 ganglioside, and globotriaosylceramide by arylsulfatase A, acid beta-galactosidase, and alpha-galactosidase, respectively. Human saposin B deficiency, transmitted as an autosomal recessive trait, results in tissue accumulation of cerebroside sulfate and a clinical picture resembling metachromatic leukodystrophy (activator-deficient metachromatic leukodystrophy). We have examined transformed lymphoblasts from the initially reported saposin B-deficient patient and found normal amounts of saposins A, C, and D. After preparing first-strand cDNA from lymphoblast total RNA, we used the polymerase chain reaction to amplify the prosaposin cDNA. The patient's mRNA differed from the normal sequence by only one C----T transition in the 23rd codon of saposin B, resulting in a threonine to isoleucine amino acid substitution. An affected male sibling has the same mutation as the proband and their heterozygous mother carries both the normal and mutant sequences, providing additional evidence that this base change is the disease-causing mutation. This base change results in the replacement of a polar amino acid (threonine) with a nonpolar amino acid (isoleucine) and, more importantly, eliminates the glycosylation signal in this activator protein. One explanation for the deficiency of saposin B in this disease is that the mutation may increase the degradation of saposin B by exposing a potential proteolytic cleavage site (arginine) two amino acids to the amino-terminal side of the glycosylation site when the carbohydrate side chain is absent. 相似文献
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Leo J. Davis Jr PhD Richard D Hurt MD Robert M Morse MD Peter C. O''Brien PhD 《Alcoholism, clinical and experimental research》1987,11(3):269-273
For a sample of 1156 patients (520 alcoholics and 636 nonalcoholics), discriminant function analyses were performed on the total score, a nine-item version, and a two-item version of the Self-Administered Alcoholism Screening Test (SAAST). With sensitivities set at 90 and 95%, specificities for the total score and nine-item versions ranged from 96.4 to 99.4%. Cross-validation of the nine-item version with the "jackknife" procedure resulted in only one additional misclassification of the 1156 subjects. Separate analyses of the male and female samples revealed that more items entered the discriminant function for women than for men and resulted in a higher, although clinically nonsignificant, percentage of correct classification for women. The results strongly support the use of either the total score or the nine-item version of the SAAST in large-scale screening for alcoholism in a medical patient population. 相似文献