全文获取类型
收费全文 | 7632篇 |
免费 | 335篇 |
国内免费 | 33篇 |
专业分类
耳鼻咽喉 | 163篇 |
儿科学 | 131篇 |
妇产科学 | 189篇 |
基础医学 | 941篇 |
口腔科学 | 169篇 |
临床医学 | 531篇 |
内科学 | 1905篇 |
皮肤病学 | 171篇 |
神经病学 | 556篇 |
特种医学 | 157篇 |
外科学 | 1093篇 |
综合类 | 81篇 |
预防医学 | 678篇 |
眼科学 | 183篇 |
药学 | 408篇 |
中国医学 | 32篇 |
肿瘤学 | 612篇 |
出版年
2023年 | 46篇 |
2022年 | 96篇 |
2021年 | 230篇 |
2020年 | 121篇 |
2019年 | 214篇 |
2018年 | 232篇 |
2017年 | 142篇 |
2016年 | 149篇 |
2015年 | 172篇 |
2014年 | 263篇 |
2013年 | 355篇 |
2012年 | 590篇 |
2011年 | 629篇 |
2010年 | 359篇 |
2009年 | 363篇 |
2008年 | 542篇 |
2007年 | 533篇 |
2006年 | 464篇 |
2005年 | 497篇 |
2004年 | 443篇 |
2003年 | 377篇 |
2002年 | 437篇 |
2001年 | 54篇 |
2000年 | 60篇 |
1999年 | 79篇 |
1998年 | 54篇 |
1997年 | 57篇 |
1996年 | 44篇 |
1995年 | 32篇 |
1994年 | 37篇 |
1993年 | 39篇 |
1992年 | 25篇 |
1991年 | 21篇 |
1990年 | 14篇 |
1989年 | 19篇 |
1988年 | 20篇 |
1987年 | 10篇 |
1986年 | 15篇 |
1985年 | 10篇 |
1984年 | 16篇 |
1983年 | 11篇 |
1982年 | 19篇 |
1980年 | 13篇 |
1979年 | 5篇 |
1978年 | 10篇 |
1976年 | 6篇 |
1975年 | 5篇 |
1974年 | 11篇 |
1973年 | 5篇 |
1971年 | 6篇 |
排序方式: 共有8000条查询结果,搜索用时 15 毫秒
71.
72.
Escarlata Angullo-Martínez Enrique Carretero-Anibarro Ignacio Manuel Snchez Barrancos Xavier Cos Claramunt Domingo Orozco Beltrn Jos Luis Torres Baile Patxi Ezkurra Loiola en representacin del Grupo de Trabajo de Diabetes de la SemFyC en representacin del Grupo de Trabajo de Diabetes de la SemFyC 《Atencion primaria / Sociedad Espa?ola de Medicina de Familia y Comunitaria》2021,53(4)
Las circunstancias actuales provocadas por la COVID-19 nos obligan a los profesionales de atención primaria a idear nuevas formas de garantizar la atención sanitaria de nuestros pacientes con diabetes tipo 2 (DM2). Existen evidencias que respaldan la eficacia de la telemedicina en el control glucémico de los pacientes con DM2. Ante la rápida adaptación de la práctica clínica al uso de la telemedicina, el Grupo de Trabajo de Diabetes de la Sociedad Española de Medicina Familiar y Comunitaria (SemFyC) optó por elaborar un documento de consenso plasmado en un algoritmo de actuación/seguimiento telemático en la atención de los pacientes con DM2.Palabras clave: Telemedicina, Diabetes mellitus tipo 2, COVID-19 相似文献
73.
74.
The comorbidity of post-traumatic stress disorder (PTSD) and drug addiction is quite often overlooked in refugees. However, the simultaneous treatment of both disorders is of elemental importance for a positive outcome in addicted and traumatised refugees. Furthermore, mutual misinterpretations of habits, behaviours and reactions through negligence of the distinct sociocultural context of patient and clinician often leads to unfavourable developments. These observations are exemplified in this case report. 相似文献
75.
Enrique Casalino Donia Bouzid Stephanie Antoniol Philippe Kenway Laurent Pereira Christophe Choquet Emergency Department Study Group on Respiratory Viruses 《Internal and emergency medicine》2018,13(5):673-678
To evaluate the impact of an influenza vaccination (IV) coverage (IVC) in a vaccination campaign of an Emergency Department (EDVC) and its impact on ED time interval quality indicators. We conducted a 4 year observational study, with an intervention during the 4th year. IVC was calculated during pre-and early-epidemic periods. During the final period, a 12 weeks EDVC was implemented. Physicians and nurses were trained and sensitized in the importance of vaccination, and their role in the prevention of severe forms of influenza was reinforced. The vaccine was proposed by physicians and nurses, and delivered by them. Repeated measures ANOVA is a validated method for related not independent groups (https://statistics.laerd.com/statistical-guides/repeated-measures-anova-statistical-guide.php). Overall, IVC was 987/3191 (30.9%) with an increasing trend from 28.8 to 33.2%. In the fourth period, out of 868 patients identified with IV indication, 288 had already been vaccinated (IVC?33.2%). After excluding patients presenting criteria of exclusion, IV was proposed to 475 patients: 317 (66.7%) accepted. The vaccination rate after patient’s acceptance was 89.6% (288/317). At the end of the EDVC, influenza vaccination coverage was 572 (284?+?288)/868 (65.9%). The delay between arrival at the ED and seeing the triage nurse and physician as well as the overall ED length of stay were not modified during the study period and before and during EDVC. EDVC effectively doubled the influenza vaccination coverage, without modifying ED time interval quality indicators. 相似文献
76.
77.
Efficacy of rituximab in an aggressive form of multicentric Castleman disease associated with immune phenomena 总被引:4,自引:0,他引:4
Ocio EM Sanchez-Guijo FM Diez-Campelo M Castilla C Blanco OJ Caballero D San Miguel JF 《American journal of hematology》2005,78(4):302-305
Multicentric Castleman disease (MCD) is an uncommon lymphoproliferative disorder for which the best therapeutic option is not yet well established. Immune-related disorders are rare complications of MCD. We report on an MCD case in a 23-year-old patient with extensive abdominal involvement and associated immune hemolytic anemia and Raynaud phenomenon. He was negative for human immunodeficiency virus (HIV) and human herpesvirus-8 (HHV-8). After 8 courses of the anti-CD20 monoclonal antibody (rituximab), the patient achieved complete remission. Interestingly, Raynaud phenomenon disappeared under treatment and no new hemolytic events occurred. Anti-CD20 antibody treatment could be an attractive therapeutic approach for MCD, mainly when immune-related disorders are associated. 相似文献
78.
Kimatrai M Blanco O Muñoz-Fernández R Tirado I Martin F Abadía-Molina AC Olivares EG 《The Journal of clinical endocrinology and metabolism》2005,90(11):6126-6130
CONTEXT: Human decidual stromal cells (DSC) are myofibroblast-like cells that express alpha-smooth muscle (alpha-SM) actin, a protein associated with cell contractility. Several lines of experimental evidence in humans and mice show that antiinflammatory cytokines favor normal pregnancy, whereas Th1 and inflammatory cytokines play a role in abortion. We previously demonstrated that IL-2, a Th1 cytokine, increased the contractility of human DSC. OBJECTIVE: We studied the effect of the antiinflammatory cytokines IL-10 and IL-4 on the contractility of DSC from first-trimester pregnancy. SETTING AND PATIENTS: We studied 10 healthy women who underwent elective vaginal termination of first-trimester pregnancy at Clínica El Sur, Málaga, and Clínica Ginegranada, Granada. MAIN OUTCOME MEASURE(S): After isolation of DSC, cell contractility was measured with the collagen gel contraction assay. alpha-SM actin was detected with Western blotting and immunofluorescence. RESULTS: We found that IL-10, but not IL-4, increased the volume of the collagen gel matrixes in which the cytokine-treated DSC were cultured, showing that IL-10 decreased DSC contractility. By Western blotting we demonstrated that this effect was not related to an alteration in the synthesis of alpha-SM actin. Nevertheless, we observed by immunofluorescence microscopy that DSC treated with IL-10 exhibited stress fibers with a lower content of alpha-SM actin than untreated control DSC. CONCLUSIONS: IL-10 relaxes DSC by reducing the incorporation of alpha-SM actin into their stress fibers. This relaxing activity may be of relevance for the maintenance of pregnancy. 相似文献
79.
Seijo Ríos S Lariño Noia J Iglesias García J Lozano León A Domínguez Muñoz JE 《Gastroenterologia y hepatologia》2008,31(2):92-97
Primary cystic pancreatic neoplasms are rare tumors, with an approximate prevalence of 10% of cystic pancreatic lesions. Most of these lesions correspond to mucinous cystic neoplasm, serous cystoadenoma and intraductal papillary mucinous tumor (IPMT). IPMT is characterized by diffuse dilatation of the main pancreatic duct and/or side branches with inner defects related to mucin or tumor, or mucin extrusion from a patent ampulla. IPMT has a low potential for malignancy, with a low growth rate, a low rate of metastatic spread and postsurgical recurrence. Over the last few years, major advances have been made in the diagnostic and therapeutic management of this tumor. 相似文献
80.
González Hernández E Cabadés O'Callaghan A Cebrián Doménech J López Merino V Sanjuán Mañez R Echánove Errazti I Valencia Martín J Bertomeu Martínez V;Investigadores del estudio PRIMVAC 《Revista espa?ola de cardiología》2004,57(1):12-19
INTRODUCTION AND OBJECTIVES: Some authors have described seasonal variations in the incidence of acute myocardial infarction. The aim of this study was to determine the existence of seasonal rhythms in admissions for acute myocardial infarction to coronary care units, and in mortality, and to analyze the influence of age on environmental factors. PATIENTS AND METHOD: The study included a total of 8400 consecutive patients with acute myocardial infarction admitted to 12 coronary care units in the PRIMVAC registry from January 1995 to December 1999. Seasonal rhythms were analyzed with the time series method and the Cosinor regression equation. The influence of age was analyzed with the chi 2 test. RESULTS: The total number of admissions increased in winter and decreased in summer. The highest peak (acrophase) occurred in winter, with 2183 cases (r2=0.91), specifically in February, with 742 cases (r2=0.66). The age of the patients conditioned seasonal variations (P=.006), and the influence was statistically significant for patients over 65 years of age. Changes in mortality with time did not reach statistical significance. CONCLUSIONS: A seasonal rhythm in admissions for acute myocardial infarction was found, with an increase in winter and a decrease in summer. Age conditioned the effect of environmental factors on acute myocardial infarction, and patients aged 65 years or older were more sensitive to mechanisms that led to increases in admissions in winter. 相似文献