全文获取类型
收费全文 | 9355篇 |
免费 | 600篇 |
国内免费 | 76篇 |
专业分类
耳鼻咽喉 | 159篇 |
儿科学 | 241篇 |
妇产科学 | 282篇 |
基础医学 | 1068篇 |
口腔科学 | 141篇 |
临床医学 | 877篇 |
内科学 | 2342篇 |
皮肤病学 | 135篇 |
神经病学 | 990篇 |
特种医学 | 281篇 |
外科学 | 1617篇 |
综合类 | 85篇 |
一般理论 | 2篇 |
预防医学 | 617篇 |
眼科学 | 77篇 |
药学 | 521篇 |
1篇 | |
中国医学 | 28篇 |
肿瘤学 | 567篇 |
出版年
2024年 | 12篇 |
2023年 | 78篇 |
2022年 | 209篇 |
2021年 | 368篇 |
2020年 | 193篇 |
2019年 | 322篇 |
2018年 | 334篇 |
2017年 | 230篇 |
2016年 | 282篇 |
2015年 | 337篇 |
2014年 | 414篇 |
2013年 | 540篇 |
2012年 | 803篇 |
2011年 | 798篇 |
2010年 | 406篇 |
2009年 | 353篇 |
2008年 | 624篇 |
2007年 | 668篇 |
2006年 | 582篇 |
2005年 | 556篇 |
2004年 | 500篇 |
2003年 | 481篇 |
2002年 | 378篇 |
2001年 | 55篇 |
2000年 | 46篇 |
1999年 | 44篇 |
1998年 | 56篇 |
1997年 | 32篇 |
1996年 | 35篇 |
1995年 | 30篇 |
1994年 | 21篇 |
1993年 | 24篇 |
1992年 | 15篇 |
1991年 | 17篇 |
1990年 | 15篇 |
1989年 | 19篇 |
1988年 | 9篇 |
1987年 | 6篇 |
1986年 | 5篇 |
1985年 | 14篇 |
1984年 | 10篇 |
1983年 | 16篇 |
1982年 | 14篇 |
1981年 | 11篇 |
1980年 | 8篇 |
1979年 | 5篇 |
1977年 | 5篇 |
1976年 | 6篇 |
1974年 | 5篇 |
1971年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
52.
Horsmans Y Hu K Ruffin M Wang Y Song D Bouillaud E Wang Y Mazur D Botha FP Heuman DM 《Journal of clinical pharmacology》2012,52(4):552-558
Pasireotide is a novel, multireceptor-targeted somatostatin analogue with high affinity for sst(1,2,3) and sst(5) under clinical evaluation in tumors of neuroendocrine origin, including Cushing's disease, acromegaly, and neuroendocrine tumors. In this phase I, open-label, multicenter study, the pharmacokinetics and safety of a single subcutaneous (SC) injection of pasireotide 600 μg were evaluated in adults with normal hepatic function (n = 15) and mild (n = 6), moderate (n = 7), or severe hepatic impairment (n = 6). Following a single dose of pasireotide SC 600 μg, there were no significant differences in the plasma exposure of pasireotide between participants with normal hepatic function or mild hepatic impairment. Subjects with moderate and severe hepatic impairment showed an increase in AUC(∞) by 56% and 42%, respectively; this increase was 60% and 79% respectively, after adjusting for differences in age, BMI, and baseline serum albumin level between treatment groups. The incidence and severity of adverse events were similar across cohorts, with no clinically relevant differences in type or frequency of adverse events between cohorts. In conclusion, a single dose of pasireotide SC 600 μg was well tolerated in subjects with hepatic impairment. Drug exposure in subjects with mild hepatic impairment was similar to that seen in healthy volunteers, whereas subjects with moderate and severe hepatic impairment experienced higher exposure to pasireotide. Adjustment of the pasireotide dose may be required for patients with moderate and severe hepatic impairment. 相似文献
53.
54.
Small intestinal obstruction and perforation associated with endometriosis is uncommon. We report a similar effect following treatment with the combined oral contraceptive. Caution should be exercised when prescribing the combined oral contraceptive in women with suggested small intestinal endometriosis. Disease flare-up after therapy may be associated with intestinal obstruction and perforation. 相似文献
55.
56.
White Franklin W. John Arnold P. Meikle Deutsch Emmanuel Kark Robert 《The American journal of digestive diseases》1941,8(9):346-353
The American Journal of Digestive Diseases - 相似文献
57.
Xinmei Zhang Emmanuel Eric Pazo Aoqi Zhang Lanting Yang Guangzheng Dai Xianwei Wu Yang Xia Amit Meshi Wei He Tiezhu Lin 《Korean journal of ophthalmology : KJO》2022,36(3):210
PurposeTo assess the feasibility of applying ultra-widefield fundus (UWF) images for macular staphyloma area (MSA) measurement and investigate the associated factors with MSA.MethodsThis is a retrospective study. MSA was measured by UWF imaging. Central foveal thickness, subfoveal choroidal thickness, subfoveal scleral thickness were measured on spectral domain optical coherence tomography. Intraclass correlation coefficients of MSA measurement would be evaluated. Multiple linear regression analysis was used to analyze the associated factors with MSA.ResultsIn total, 135 eyes of 92 patients were enrolled. The mean age was 64.73 ± 10.84 years. Mean MSA on UWF image was 279.67 ± 71.70 mm2. Intraclass correlation coefficients of MSA measurement was 0.965 (95% confidence interval [CI], 0.946 to 0.977; p < 0.001). In the multiple linear regression analysis, after adjusting for subfoveal choroidal thickness, best-corrected visual acuity, central foveal thickness, and subfoveal scleral thickness, the factors independently related to MSA were axial length (β = 8.352; 95% CI, 3.306 to 13.398; p = 0.001), sex (β = −26.673; 95% CI, −51.759 to −1.586; p = 0.037), age (β = 1.184; 95% CI, 0.020 to 2.348; p = 0.046).ConclusionsIt is feasible to measure MSA on UWF image. Female, longer axial length, and older age may indicate larger MSA. 相似文献
58.
Reinaldo Dal Bello Justine Pasanisi Romane Joudinaud Matthieu Duchmann Bryann Pardieu Paolo Ayaka Giuseppe Di Feo Gaetano Sodaro Clmentine Chauvel Rathana Kim Loic Vasseur Laureen Chat Frank Ling Kim Pacchiardi Camille Vaganay Jeannig Berrou Chaima Benaksas Nicolas Boissel Thorsten Braun Claude Preudhomme Herv Dombret Emmanuel Raffoux Nina Fenouille Emmanuelle Clappier Lionel Ads Alexandre Puissant Raphael Itzykson 《Blood cancer journal》2022,12(6)
59.
Emmanuel de Billy Marsha Pellegrino Domenico Orlando Giulia Pericoli Roberta Ferretti Pietro Businaro Maria Antonietta Ajmone-Cat Sabrina Rossi Lucia Lisa Petrilli Nicola Maestro Francesca Diomedi-Camassei Marco Pezzullo Cristiano De Stefanis Paola Bencivenga Alessia Palma Rossella Rota Francesca Del Bufalo Luca Massimi Gerrit Weber Chris Jones Andrea Carai Simona Caruso Biagio De Angelis Ignazio Caruana Concetta Quintarelli Angela Mastronuzzi Franco Locatelli Maria Vinci 《Neuro-oncology》2022,24(7):1150
BackgroundDiffuse midline gliomas (DMG) H3K27M-mutant, including diffuse intrinsic pontine glioma (DIPG), are pediatric brain tumors associated with grim prognosis. Although GD2-CAR T-cells demonstrated significant anti-tumor activity against DMG H3K27M-mutant in vivo, a multimodal approach may be needed to more effectively treat patients. We investigated GD2 expression in DMG/DIPG and other pediatric high-grade gliomas (pHGG) and sought to identify chemical compounds that would enhance GD2-CAR T-cell anti-tumor efficacy.MethodsImmunohistochemistry in tumor tissue samples and immunofluorescence in primary patient-derived cell lines were performed to study GD2 expression. We developed a high-throughput cell-based assay to screen 42 kinase inhibitors in combination with GD2-CAR T-cells. Cell viability, western blots, flow-cytometry, real time PCR experiments, DIPG 3D culture models, and orthotopic xenograft model were applied to investigate the effect of selected compounds on DIPG cell death and CAR T-cell function.ResultsGD2 was heterogeneously, but widely, expressed in the tissue tested, while its expression was homogeneous and restricted to DMG/DIPG H3K27M-mutant cell lines. We identified dual IGF1R/IR antagonists, BMS-754807 and linsitinib, able to inhibit tumor cell viability at concentrations that do not affect CAR T-cells. Linsitinib, but not BMS-754807, decreases activation/exhaustion of GD2-CAR T-cells and increases their central memory profile. The enhanced anti-tumor activity of linsitinib/GD2-CAR T-cell combination was confirmed in DIPG models in vitro, ex vivo, and in vivo.ConclusionOur study supports the development of IGF1R/IR inhibitors to be used in combination with GD2-CAR T-cells for treating patients affected by DMG/DIPG and, potentially, by pHGG. 相似文献
60.
Louis Nevejan Lize Cuypers Lies Laenen Liselotte Van Loo Franois Vermeulen Elke Wollants Ignace Van Hecke Stefanie Desmet Katrien Lagrou Piet Maes Emmanuel Andr 《Emerging infectious diseases》2022,28(8):1729
Illustrated by a clinical case supplemented by epidemiologic data, early reinfections with SARS-CoV-2 Omicron BA.1 after infection with Delta variant, and reinfection with Omicron BA.2 after Omicron BA.1 infection, can occur within 60 days, especially in young, unvaccinated persons. The case definition of reinfection, which influences retesting policies, should be reconsidered. 相似文献