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排序方式: 共有613条查询结果,搜索用时 125 毫秒
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JoAnn M. Tufariello Jessica R. Chapman Christopher A. Kerantzas Ka-Wing Wong Catherine Vilchèze Christopher M. Jones Laura E. Cole Emir Tinaztepe Victor Thompson David Feny? Michael Niederweis Beatrix Ueberheide Jennifer A. Philips William R. Jacobs Jr. 《Proceedings of the National Academy of Sciences of the United States of America》2016,113(3):E348-E357
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Rifampicin Carrying Poly (D, L-Lactide)/Poly(Ethylene Glycol) Microspheres: Loading and Release 总被引:1,自引:0,他引:1
Abstract: The aim of this study is to prepare rifampicinloaded poly ( d , l -lactide)/poly(ethylene glycol) (PDLLA/PEG) copolymer microspheres as an injectable drug delivery system. PDLLA homopolymers with three different molecular weights (9,760, 14,540, and 23,050 daltons) were synthesized and then transesterified with PEG (with a molecular weight of approximately 3,300-4,000 daltons). By changing the ratio of PEG to PDLLA, block copolymers with different chain structures were synthesized. PDLLA and PDLLA/PEG microspheres in the size range of 2–10 μm were prepared by a modified solvent evaporation technique with the use of methylene chloride as the solvent and methyl cellulose as the emulsifier within the aqueous dispersion medium. Rifampicin was loaded within the microspheres during particle formation. Effects of the solvent/polymer and drug/polymer ratios, PDLLA molecular weight, and PEG content on drug loading and release were investigated. High drug loadings up to 100 mg rifampicin/g polymer were achieved. Both size and drug loadings were decreased by an increase in the solvent/polymer ratio and PEG content and by a decrease in the drug/polymer ratio and PDLLA molecular weight. High release rates were observed in the first 5 days after which constant and slow release rates were noted. Drug release was decreased by a decrease in the solvent/polymer ratio and PEG content and by an increase in the drug/polymer ratio and PDLLA molecular weight. 相似文献
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AIM: A modified Barcat operation, when carried out properly, provides an anatomically and cosmetically successful result in distal hypospadias repair in each glans configuration. We retrospectively evaluated our experience with this technique in the last five years. PATIENTS AND METHODS: 78 children with primary distal type hypospadias were operated between 1998 - 2003, using a modified Barcat technique. RESULTS: The mean age of the patients was 3 years (6 months - 14 years). The mean follow-up period was 2 years (1 month - 60 months). Nesbit plication was performed in four cases with chordee. Fistula developed in five (6.5 %) cases and required reoperation. Stenosis which did not require surgical intervention occurred in 5 children and resolved with self-dilatations. CONCLUSION: The Barcat technique is an appropriate operation for distal type hypospadias cases but should be modified by creating second tissue layers over the neourethra and a wide meatus. 相似文献
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M. Nasimul Islam Emir A. Zikria Mary Ellen Sullivan Arwind Koimattur William B. Ford S.R. Samadani William H. Miller 《The Annals of thoracic surgery》1981,31(6):569-573
Despite widespread success with Gore-Tex (polytetrafluoroethylene) vascular grafts in peripheral artery operations, very little use has been made of this material in aortocoronary bypasses. We present the case of a 61-year-old woman with a 6-month history of angina who was found to have no suitable saphenous vein available at operation and who therefore underwent Gore-Tex bypass grafting to the right coronary artery. Coronary angiograms made 6 months and 18 months postoperatively showed patency of the 6 mm Gore-Tex replacement graft as well as the internal mammary artery placed to the left anterior descending coronary artery.Although frequent follow-up and close observation are recommended in patients with aortocoronary Gore-Tex grafting, the unique design of this material has made it the best alternative for synthetic coronary bypass conduit in the absence of the saphenous veins, particularly when these veins are found to be inadequate only at the time of operation. 相似文献
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Zieliński Grzegorz Sajjad Emir Ahmed Maksymowicz Maria Pękul Monika Koziarski Andrzej 《Pituitary》2019,22(6):620-632
Pituitary - To explore the incidence of double pituitary adenomas in a tertiary center for pituitary surgery and asses their clinical, imaging and histopathological features. The medical records of... 相似文献
70.
Orhan Maden Fehmi Kacmaz Hatice Selcuk Mehmet T Selcuk Tolga Aksu Omac Tufekcioglu Emir K Senen Yucel Balbay Erdogan Ilkay 《The Canadian journal of cardiology》2009,25(6):e164-e168