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Derya Özyörük Hacı Ahmet Demir Suna Emir Asuman Nihan Haberal Meral Bugdaycı İbrahim Ötgün 《Pediatric hematology and oncology》2014,31(4):362-365
Primary ovarian malignant melanoma arising in teratomatous component of germ cell tumors is seen extremely rare with most reports being only of single cases and small series in reproductive aged woman and mostly from cystic teratoma, whereas information on pediatric presentation is sparse. This case is reported for being extremely rare tumor. 相似文献
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Jeanna Wallenta Law Debanjali Mitra Henry G. Kaplan Tamuno Alfred Adam M. Brufsky Birol Emir Haley McCracken Xianchen Liu Ronda G. Broome Chenan Zhang Caroline DiCristo Connie Chen 《Current oncology (Toronto, Ont.)》2022,29(2):1047
This retrospective single-arm study assessed real-world treatment patterns and clinical outcomes in patients with hormone receptor—positive/human epidermal growth factor receptor 2—negative (HR+/HER2−) advanced/metastatic breast cancer (A/MBC) who received palbociclib plus an aromatase inhibitor as first-line therapy in US community health systems. Using electronic health records from the Syapse Learning Health Network, 242 patients were identified as having received first-line palbociclib plus an aromatase inhibitor between 3 February 2015, and 31 July 2019 (data cutoff 1 February 2020) resulting in a minimum potential 6-month follow-up period. In total, 56.6% of patients had de novo A/MBC at initial breast cancer diagnosis, 50.8% had bone-only disease, and 32.2% had visceral disease. Median follow-up was 22.4 months. Disease progression (26.4%) and intolerance/toxicity (14.9%) were the main reasons for treatment discontinuation. The median (95% CI) real-world progression-free survival was 31.7 (27.9—not estimable (NE)) months and 2-year estimated overall survival (OS) rate was 78.0%. In total, 25.6% of patients died; however, OS data are limited by the small population size and insufficient follow-up time. These real-world effectiveness outcomes complement findings from other real-world studies and randomized controlled trials and support palbociclib plus an aromatase inhibitor as first-line therapy for HR+/HER2− A/MBC. 相似文献
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Emir Kamenica Robert Naclerio Anup Malani 《Proceedings of the National Academy of Sciences of the United States of America》2013,110(32):12931-12935
We conducted randomized clinical trials to examine the impact of direct-to-consumer advertisements on the efficacy of a branded drug. We compared the objectively measured, physiological effect of Claritin (Merck & Co.), a leading antihistamine medication, across subjects randomized to watch a movie spliced with advertisements for Claritin or advertisements for Zyrtec (McNeil), a competitor antihistamine. Among subjects who test negative for common allergies, exposure to Claritin advertisements rather than Zyrtec advertisements increases the efficacy of Claritin. We conclude that branded drugs can interact with exposure to television advertisements. 相似文献
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In this article, a 9-year-old boy with arterial priapism is presented. The patient was managed with the conservative measures including imipramine hydrochloride and a favorable outcome was achieved after 2 months of follow-up. The pathophysiology, diagnostic tools and treatment alternatives are discussed. 相似文献
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A psoas abscess is, either primary or secondary, a rare entity for a general surgeon. Images by ultrasonography and computed
tomography (CT) can help a general surgeon to make an accurate diagnosis when encountering the patient complaining of unilateral
lower abdominal deep pain with fever. A case of pyogenic abscess of the psoas muscle as a result of sacroiliitis in a 22-year-old
man is reported herein. The abdominal CT and magnetic resonance imaging scans demonstrated a large multilocular abscess extending
along the iliopsoas muscle, and erosion and a widening of the left sacroiliac joint. The abscess was drained with an open
surgical approach and the patient responded well to antibiotic therapy. Aggressive surgical and medical treatment is necessary
in patients with psoas abscess to prevent complications.
Received: March 5, 2001 / Accepted: November 20, 2001 相似文献