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61.
Davide Firinu Vanessa Garcia-Larsen Paolo Emilio Manconi Stefano R. Del Giacco 《Current rheumatology reports》2016,18(6):35
SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis, and osteitis) is a rare autoimmune disease which, due to its clinical presentation and symptoms, is often misdiagnosed and unrecognized. Its main features are prominent inflammatory cutaneous and articular manifestations. Treatments with immunosuppressive drugs have been used for the management of SAPHO with variable results. To date, the use of anti-TNF-α agents has proved to be an effective alternative to conventional treatment for unresponsive or refractory SAPHO cases. TNF-α is a pro-inflammatory cytokine and pivotal regulator of other cytokines, including IL-1 β, IL-6, and IL-8, involved in inflammation, acute-phase response induction, and chemotaxis. IL-1 inhibition strategies with anakinra have shown efficacy as first and second lines of treatment. In this review, we will describe the main characteristics of biological drugs currently used for SAPHO syndrome. We also describe some of the promising therapeutic effects of ustekinumab, an antibody against the p40 subunit of IL-12 and IL-23, after failure of multiple drugs including anti-TNF-α and anakinra. We discuss the use and impact of the new anti-IL-1 antagonists involved in the IL-17 blockade, in particular for the most difficult-to-treat SAPHO cases. 相似文献
62.
José García-Cosamalón Javier Fernández-Fernández Emilio González-Martínez Javier Ibáñez-Plágaro Javier Robla Costales Milton Martínez-Madrigal Alfonso López Muñíz Miguel Enrique del Valle José Antonio Vega 《Neurocirugía (Asturias, Spain)》2013,24(3):121-129
Until very recently, intervertebral disc innervation was a subject of considerable debate.Nowadays, the introduction of inmunohistochemical techniques associated to specific antibodies and studies with retrograde tracers in nerves have allowed greater understanding of disc innervation in physiological and pathological conditions and also endings characteristics and their patterns of distribution in both situations. The existing controversies regarding structural basis of discogenic pain, have raised the interest of knowing the influence of innervation in back pain from discal origin and its characteristics.Today, we know that pathologic neoinnervation accompanying radial fissures is an important factor in the genesis of discogenic pain; within a complex mechanism in which other neurobiomechemical, inflammatory and biomechanical factors are involved. 相似文献
63.
Barberis María Eugenia Palma Santiago Daniel Gonzo Elio Emilio Bermúdez José María Lorier Marianela Ibarra Manuel Real Juan Pablo 《Pharmaceutical research》2022,39(9):2277-2290
Pharmaceutical Research - 3D printing (3DP) makes it possible to obtain systems that are not achievable with current conventional methods, one of them, sustained release floating systems. Floating... 相似文献
64.
Migration of titanium dioxide microparticles and nanoparticles through the body and deposition in the gingiva: an experimental study in rats 下载免费PDF全文
María B. Guglielmotti Mariela G. Domingo Tammy Steimetz Emilio Ramos María L. Paparella Daniel G. Olmedo 《European journal of oral sciences》2015,123(4):242-248
The aim of this experimental work was to evaluate deposition of titanium dioxide (TiO2) microparticles and nanoparticles, which could originate from titanium bioimplants, in the gingiva. Wistar rats were injected intraperitoneally (i.p.) with a suspension of TiO2 particles of different sizes (150, 10, or 5 nm). The rats were killed 12 months post‐injection, and the buccal and lingual gingivae were resected and evaluated using light and scanning electron microscopy. Energy‐dispersive X‐ray spectroscopy (EDS) was used to confirm the presence of titanium in deposits of microparticles and nanoparticles, and the concentration of titanium in tissues was measured using inductively coupled plasma–mass spectrometry (ICP‐MS). Histological examination showed that all experimental groups exhibited agglomerates, in the gingiva, of titanium particles of micrometer size range, with no associated inflammatory response. Higher concentrations of titanium traces were shown, by ICP‐MS, in both buccal and lingual tissues of all experimental groups compared with their matched controls. Titanium concentrations were significantly higher in the buccal gingiva than in the lingual gingiva, and after injection with 5‐nm particles than with 10‐nm particles in both localizations. Titanium microparticles and nanoparticles deposit in the gingiva, and mostly on the buccal side. Gingival deposition of titanium could be considered a tissue indicator of tribocorrosion processes of titanium bioimplants. 相似文献
65.
Clinical and immunological characteristics of a pediatric population with food protein‐induced enterocolitis syndrome (FPIES) to fish 下载免费PDF全文
66.
67.
Silvia Alberti‐Violetti M.D. Pamela Vezzoli M.D. Ph.D. Laura Corti Ph.D. Daniele Fanoni M.Sc. Valentina Merlo M.Sc. Luigia Venegoni M.L.T. Alberto Reseghetti M.D. Emilio Berti M.D. 《Pediatric dermatology》2016,33(5):e318-e321
We describe the case of a 17‐year‐old Hispanic boy who had had erythroderma and diffuse lymphadenopathy for approximately 6 months. A diagnosis of Sézary syndrome was made on the basis of the histologic features of the skin; the presence of the same T‐cell clone on the skin, blood, and bone marrow; and the high CD4+ lymphocyte count with an aberrant phenotype in peripheral blood; bone marrow involvement was also present. The patient was treated with systemic gemcitabine and achieved partial remission. 相似文献
68.
Manuel David Gil-Sierra PharmD Silvia Fénix-Caballero PharmD Laila Abdel kader-Martin PharmD Maria Dolores Fraga-Fuentes PharmD Marina Sánchez-Hidalgo PharmD Catalina Alarcón de la Lastra-Romero PharmD Emilio Jesús Alegre-del Rey PharmD 《Journal of clinical pharmacy and therapeutics》2020,45(3):530-538
69.
Emilio Domínguez‐Salazar Gabriela Hurtado‐Alvarado Fernanda Medina‐Flores Javik Dorantes Oscar Gonzlez‐Flores Arturo Contis‐Montes de Oca Javier Velzquez‐Moctezuma Beatriz Gmez‐Gonzlez 《Journal of sleep research》2020,29(3)
Sleep loss increases blood–brain barrier permeability. As the blood–brain barrier and the blood–tissue barriers in the reproductive tract (blood–testis and blood–epididymis barriers) share common characteristics, we hypothesized that sleep restriction may also modify their barrier function. Previous reports showed that sleep loss decreased sperm viability and progressive fast mobility, which may be a consequence of altered blood–testis and blood–epididymis barrier. Therefore, we quantified changes in blood–testis and blood–epididymis barrier after sleep loss and related them to male fertility. Adult male Wistar rats were sleep restricted using the multiple‐platform technique in a protocol of 20 hr daily sleep deprivation plus 4 hr of sleep recovery in the home‐cage. At the 10th day, barrier permeability assays were performed with Na‐fluorescein, 10 kDa Cascade blue‐dextrans and Evans blue, and the expression of tight junction proteins, actin and androgen receptor was quantified. At the 10th day of sleep restriction and after sleep recovery days 1–7, males were placed with sexually receptive females, sexual behaviour was tested, and the percentage of pregnancies was calculated. Sleep restriction increased the barrier permeability to low‐ and high‐molecular‐weight tracers, and decreased the expression of tight junction proteins, actin and androgen receptor. Concomitantly, sleep restriction reduced the percentage of ejaculating males and the number of pregnancies. Sleep recovery for 2–3 days progressively re‐established fertility, as indicated by a higher percentage of ejaculating males and impregnated females. In conclusion, chronic sleep loss alters fertility concomitantly with the disruption of the blood–tissue barriers at the reproductive tract, the mechanism involves androgen signalling. 相似文献
70.