全文获取类型
收费全文 | 2992篇 |
免费 | 349篇 |
国内免费 | 14篇 |
专业分类
耳鼻咽喉 | 39篇 |
儿科学 | 103篇 |
妇产科学 | 146篇 |
基础医学 | 318篇 |
口腔科学 | 88篇 |
临床医学 | 192篇 |
内科学 | 666篇 |
皮肤病学 | 172篇 |
神经病学 | 116篇 |
特种医学 | 170篇 |
外国民族医学 | 6篇 |
外科学 | 507篇 |
综合类 | 54篇 |
预防医学 | 210篇 |
眼科学 | 39篇 |
药学 | 295篇 |
中国医学 | 18篇 |
肿瘤学 | 216篇 |
出版年
2023年 | 11篇 |
2022年 | 66篇 |
2021年 | 122篇 |
2020年 | 89篇 |
2019年 | 157篇 |
2018年 | 172篇 |
2017年 | 138篇 |
2016年 | 134篇 |
2015年 | 157篇 |
2014年 | 176篇 |
2013年 | 207篇 |
2012年 | 223篇 |
2011年 | 228篇 |
2010年 | 155篇 |
2009年 | 135篇 |
2008年 | 106篇 |
2007年 | 119篇 |
2006年 | 109篇 |
2005年 | 111篇 |
2004年 | 93篇 |
2003年 | 85篇 |
2002年 | 82篇 |
2001年 | 20篇 |
2000年 | 19篇 |
1999年 | 29篇 |
1998年 | 16篇 |
1997年 | 16篇 |
1996年 | 18篇 |
1995年 | 13篇 |
1994年 | 10篇 |
1993年 | 12篇 |
1992年 | 29篇 |
1991年 | 14篇 |
1990年 | 16篇 |
1988年 | 20篇 |
1987年 | 19篇 |
1986年 | 14篇 |
1985年 | 22篇 |
1984年 | 11篇 |
1982年 | 11篇 |
1980年 | 11篇 |
1979年 | 16篇 |
1978年 | 10篇 |
1977年 | 8篇 |
1976年 | 10篇 |
1971年 | 11篇 |
1970年 | 10篇 |
1969年 | 9篇 |
1968年 | 7篇 |
1967年 | 12篇 |
排序方式: 共有3355条查询结果,搜索用时 62 毫秒
81.
BACKGROUND: An increased expression of Fos, the protein product of the immediate early gene c-fos, in the nucleus tractus solitarius (NTS) is associated with dysfunction in baroreceptor reflex control of heart rate. Our previous studies demonstrated that ethanol attenuates baroreflex sensitivity (BRS) in rats and humans. In this study, we tested the hypothesis that enhanced expression of the immediate early gene c-jun (an index of neuronal activity) in the NTS contributes to the baroreflex dysfunction caused by ethanol. METHODS: Conscious male spontaneously hypertensive (SHR) and Wistar-Kyoto (WKY) rats were used to measure blood pressure, heart rate, and baroreflex sensitivity (Oxford method). The c-jun messenger RNA (mRNA) expression in NTS was measured by in situ hybridization. RESULTS: Ethanol elicited dose-dependent attenuation in BRS in WKY rats, which was associated with significant increases in c-jun mRNA in the NTS. In contrast, ethanol had no effect on BRS or c-jun mRNA in the NTS of the SHRs; the latter exhibited significantly lower BRS and higher c-jun mRNA in the NTS compared with WKY rats. CONCLUSIONS: An increased basal level of c-jun mRNA in the NTS may contribute to the reduced BRS in the SHR, and ethanol enhancement of neuronal activity of the NTS, expressed as increased c-jun mRNA expression, may contribute to its attenuation of BRS, which highlights the NTS as a neuroanatomical target for ethanol action on baroreflexes. 相似文献
82.
83.
84.
85.
De Novo 17q24.2–q24.3 microdeletion presenting with generalized hypertrichosis terminalis,gingival fibromatous hyperplasia,and distinctive facial features
下载免费PDF全文
![点击此处可从《American journal of medical genetics. Part A》网站下载免费的PDF全文](/ch/ext_images/free.gif)
86.
Clinical and molecular characterization of seven Egyptian families with autosomal recessive robinow syndrome: Identification of four novel ROR2 gene mutations
下载免费PDF全文
![点击此处可从《American journal of medical genetics. Part A》网站下载免费的PDF全文](/ch/ext_images/free.gif)
87.
Mohamed F. Abdel Rahman Ingy M. Hashad Khaled Abou-Aisha Sahar M. Abdel-Maksoud Mohamed Z. Gad 《Archives of Medical Science》2015,11(3):513-520
Introduction
The enzyme paraoxonase-1 (PON1) represents an endogenous defense mechanism against vascular oxidative stress, thereby contributing to the prevention of atherosclerosis. Several polymorphisms have been reported in the PON1 gene, including Q192R. PON1 phenotype is commonly expressed as the paraoxonase/arylesterase ratio (PON/ARE). The major aim of this study was to investigate the association between PON1 Q192R polymorphism, PON1 phenotypes and the incidence of early-onset acute myocardial infarction (AMI) in Egyptians.Material and methods
The study subjects consisted of 102 AMI patients and 72 age-matched healthy controls. Genotyping and enzyme activities were determined using PCR-RFLP and kinetic spectrophotometric assays, respectively.Results
The genotype distribution for the PON1 gene was significantly different between AMI patients (QQ = 38.24%, QR = 49.02%, RR = 12.75%) and controls (QQ = 66.67%, QR = 25%, RR = 8.33%). Allele frequencies were also significantly different between patients (Q = 62.75%, R = 37.25%) and controls (Q = 79.17%, R = 20.83%). The genotypes QR and RR showed higher risk for AMI compared to the homozygous QQ (odds ratio (OR) = 3.231, p < 0.001). The average PON/ARE ratio in MI patients (1.187 ±0.1) did not differ significantly from controls (1.118 ±0.26). However, it showed a significant difference among different genotypes in both AMI patients (QQ = 0.91 ±0.11, QR = 1.09 ±0.11 and RR = 2.65 ±0.4) (p = 0.0002) and controls (QQ = 0.68 ±0.1, QR = 1.07 ±0.11 and RR = 4.89 ±2.84) (p < 0.0001).Conclusions
PON1 192R allele represents an independent risk factor for early-onset AMI in Egyptians, and PON1 Q192R polymorphism modulates the paraoxonase phenotype. 相似文献88.
89.
Jared A White David T Redden Mary Kate Bryant David Dorn Souheil Saddekni Ahmed Kamel Abdel Aal Jessica Zarzour David Bolus J Kevin Smith Stephen Gray Devin E Eckhoff Derek A DuBay 《HPB : the official journal of the International Hepato Pancreato Biliary Association》2014,16(12):1095-1101
ObjectivesRepeat transarterial chemoembolization (TACE) is a common intervention performed for hepatocellular carcinoma (HCC). The aim of this study was to identify predictors of the need for repeat TACE.MethodsBetween 2008 and 2012, data on patient and tumour variables were collected for 262 patients treated with a first TACE procedure for HCC. The decision to perform repeat TACE procedures was made at the completion of the first TACE or after follow-up imaging demonstrated the subtotal treatment of HCC tumours.ResultsRepeat TACE was performed in 67 of 262 (25.6%) patients. Necrosis of HCC, measured after the first TACE, was lower in patients who subsequently received repeat TACE (P = 0.042). On multivariable analysis, total tumour diameter of >5 cm [odds ratio (OR) 2.76, 95% confidence interval (CI) 1.45–5.25; P = 0.002] and increasing age (OR 1.04/year, 95% CI 1.00–1.07; P = 0.030) were predictive of the need for repeat TACE. Measures of liver function and TACE approach (selective versus non-selective) were not predictive of repeat TACE. Median survival did not differ significantly between patients who did (median survival: 21.1 months) and did not (median survival: 26.1 months) receive a repeat TACE procedure (P = 0.574).ConclusionsThe requirement for repeat TACE is associated with older age, increased HCC tumour burden and subtotal TACE-induced HCC necrosis. Importantly, repeat TACE was not associated with reduced survival. 相似文献
90.