全文获取类型
收费全文 | 2760篇 |
免费 | 203篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 18篇 |
儿科学 | 96篇 |
妇产科学 | 83篇 |
基础医学 | 333篇 |
口腔科学 | 27篇 |
临床医学 | 339篇 |
内科学 | 517篇 |
皮肤病学 | 82篇 |
神经病学 | 325篇 |
特种医学 | 56篇 |
外科学 | 272篇 |
综合类 | 12篇 |
一般理论 | 4篇 |
预防医学 | 294篇 |
眼科学 | 92篇 |
药学 | 216篇 |
中国医学 | 3篇 |
肿瘤学 | 220篇 |
出版年
2024年 | 5篇 |
2023年 | 43篇 |
2022年 | 73篇 |
2021年 | 125篇 |
2020年 | 80篇 |
2019年 | 123篇 |
2018年 | 130篇 |
2017年 | 96篇 |
2016年 | 100篇 |
2015年 | 87篇 |
2014年 | 119篇 |
2013年 | 167篇 |
2012年 | 261篇 |
2011年 | 251篇 |
2010年 | 99篇 |
2009年 | 105篇 |
2008年 | 162篇 |
2007年 | 153篇 |
2006年 | 136篇 |
2005年 | 147篇 |
2004年 | 123篇 |
2003年 | 107篇 |
2002年 | 107篇 |
2001年 | 17篇 |
2000年 | 12篇 |
1999年 | 11篇 |
1998年 | 17篇 |
1997年 | 17篇 |
1996年 | 14篇 |
1995年 | 13篇 |
1994年 | 7篇 |
1993年 | 9篇 |
1992年 | 8篇 |
1991年 | 3篇 |
1990年 | 6篇 |
1988年 | 9篇 |
1985年 | 6篇 |
1984年 | 4篇 |
1983年 | 3篇 |
1982年 | 5篇 |
1981年 | 5篇 |
1980年 | 2篇 |
1979年 | 2篇 |
1978年 | 2篇 |
1976年 | 3篇 |
1966年 | 2篇 |
1933年 | 1篇 |
1927年 | 1篇 |
1920年 | 1篇 |
1915年 | 1篇 |
排序方式: 共有2989条查询结果,搜索用时 15 毫秒
11.
Chapiro E Feldmann D Denoyelle F Sternberg D Jardel C Eliot MM Bouccara D Weil D Garabédian EN Couderc R Petit C Marlin S 《European journal of human genetics : EJHG》2002,10(12):851-856
Hearing impairment is the most frequent sensory defect in children, with a genetic basis in about 50% of cases. Several point mutations and deletions in mitochondrial DNA (mtDNA) have been identified in non-syndromic sensorineural hearing loss (NSSNHL). Beside the frequent A1555G mutation, a number of mutations in tRNAs have been reported recently, but their incidence remains unknown. We identified the T7511C mutation in the tRNASer(UCN) gene in two French families with isolated deafness. Maternal transmission was obvious in both. The 15 patients with hearing impairment exhibited a variable disease phenotype in terms of onset, severity, and progression. T7511C was present in all the patients screened. Homoplasmic and heteroplasmic levels were observed and did not correlate with the severity of the disease. T7511C was also present in 12 hearing offspring of the oldest deaf mothers, confirming the existence of modulatory factors. Our data suggest that this mtDNA mutation should be screened for in all cases of familial NSSNHL compatible with maternal transmission. 相似文献
12.
We have investigated the effects of a stronger actomyosin bond on force (Ps) during rapid stretch of active permeabilized rabbit psoas muscle fibers as a function of temperature from 5 to 30 degrees C. The strength of the actomyosin bond is enhanced by addition of polyethylene glycol (PEG), especially in pre-powerstroke states [Chinn et al. (2000) Biophys J 49: 437-451]. We have hypothesized that such states produce much of the force when activated muscles are stretched [Getz et al. (1998) Biophys J 75: 2971-2983]. Addition of PEG to activated fibers produced a small increase in isometric tension, Po (50-90 kN/m2), which was approximately independent of temperature. In contrast PEG produced a dramatic increase in Ps at low temperatures (200-300 kN/m2), but a modest increase at higher temperatures (70-90 kN/m2). We also measured Ps and Po in solutions containing the phosphate analog aluminum fluoride (AlF4) with and without PEG. In the absence of PEG, AlF4 reduced Po much more than Ps. Addition of PEG did not enhance Po, but enhanced Ps significantly. The contrasting effects of PEG on Ps and Po, and the effect of temperature can be explained by a model in which stretch force is produced by pre-powerstroke cross-bridges whose maximum distension is increased by PEG, and isometric force is produced by strongly bound cross-bridges whose bond strength is also enhanced by PEG, but to a lesser extent. 相似文献
13.
Elise Rotureau Christophe Chassenieux Edith Dellacherie Alain Durand 《Macromolecular chemistry and physics.》2005,206(20):2038-2046
Summary: Amphiphilic polysaccharides are obtained by hydrophobic modification of a neutral bacterial polysaccharide, dextran. By reacting the polysaccharide with aliphatic epoxides (epoxyoctane and epoxydodecane) in dimethyl sulfoxide, a series of amphiphilic polymers is obtained which covers a large range of structural parameters (length of the polysaccharide, number and nature of hydrocarbon moieties). The solution behavior of dextran derivatives is first characterized by viscometric measurements in dilute and semi‐dilute domains. The effects of molecular parameters on polymer viscosity behavior are evidenced and discussed. Information on the state of aggregation of polymers is obtained by the use of static and dynamic light scattering. The presence of aggregates in the dilute domain is clearly evidenced and their structural characteristics are estimated (size, molecular weight and number of aggregation). The aggregates are shown to account for the viscometric results in the examined concentration range, relating their chemical parameters (hydrodynamic radius and molecular weight) to the macroscopic behavior of the solutions.
14.
15.
Bradshaw Catherine P. Pas Elise T. Musci Rashelle J. Kush Joseph M. Ryoo Ji Hoon 《Prevention science》2021,22(7):986-1000
Prevention Science - This study examined the impact of a state policy requiring that any school with a habitual truancy rate of 8% or higher to be trained in Tier 1 school-wide Positive Behavioral... 相似文献
16.
17.
Kathryn L. Young-Shand Michael J. Dunbar Elise K. Laende Joanna E. Mills Flemming Janie L. Astephen Wilson 《The Journal of arthroplasty》2021,36(7):2473-2479
BackgroundThere are numerous reports of poor satisfaction after total knee arthroplasty (TKA), yet there is little known about when to use evidence-based models of care to improve patient outcomes.ObjectiveThis study aimed to characterize longitudinal changes in patient-reported satisfaction after TKA and to identify factors for early identification of poor satisfaction.MethodsFor a cohort of primary TKA surgeries (n = 86), patient-reported outcomes were captured one week before TKA and 6 weeks, 12 weeks, 6 months, and 1 and 2 years after TKA. “Satisfied” versus “not fully satisfied” patients were defined using a binary response (≥90 vs <90) from a 100-point scale. Wilcoxon signed-rank tests identified changes in satisfaction between follow-up times, and longitudinal analyses examined demographic and questionnaire factors associated with satisfaction.ResultsImprovements in satisfaction occurred within the first 6 months after TKA (P ≤ 0.01). Preoperative patient-reported outcome measures alone were not predictive of satisfaction. Key factors that improved longitudinal satisfaction included higher Oxford Knee Scores (odds ratio (OR) = 2.1, P < .001), general health (EQ-VAS, OR = 1.3, P = .03), and less visual analog scale pain (VAS; OR = 1.7, P < .001). Differences in these factors between satisfied and not fully satisfied patients were identified as early as 6 weeks after surgery.ConclusionVisibly different satisfaction profiles were captured among satisfied and not fully satisfied patient responses, with differences in patient-perceived joint function, general health, and pain severity occurring as early as 6 weeks after surgery. This study provides metrics to support early identification of patients at risk of poor TKA satisfaction, enabling clinicians to apply timely targeted treatment and support interventions, with the aim of improving patient outcomes. 相似文献
18.
19.
Archives of Sexual Behavior - 相似文献
20.
Elise Pelgrims Sally Ann Lynch Laurens Hannes Mariëtte J. V. Hoffer Cindy Melotte Arie Van Haeringen Ann Swillen Jeroen Breckpot 《American journal of medical genetics. Part A》2023,191(7):1889-1899
Triplication of chromosomal region 1p36.3 is a rare genomic rearrangement. In this report, we delineate the phenotypic spectrum associated with 1p36.3 triplications. We describe four patients with microtriplications of variable size, but with a strong phenotypic overlap, and compare them to previously described patients with an isolated triplication or duplication of this region. The 1p36.3 triplication syndrome is associated with a distinct phenotype, characterized by global developmental delay, moderate intellectual disability, seizures, behavioral problems, and specific facial dysmorphic features, including ptosis, hypertelorism, and arched eyebrows. The de novo occurrence of these microtriplications demonstrates the reduced reproductive fitness associated with this genotype, in contrast to 1p36.3 duplications which are mostly inherited and can be associated with similar facial features but with a less severe developmental phenotype. The shared triplicated region encompasses four disease-related genes of which GABRD and SKI are most likely to contribute to the phenotype. 相似文献