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121.
Hanada E 《Annali dell'Istituto superiore di sanità》2007,43(3):208-217
Most problems with the electromagnetic environment of medical institutions have been related to radiated electromagnetic fields and have been constructed from reports about electromagnetic interference (EMI) with electronic medical equipment by the radio waves emitted from mobile telephone handsets. However, radiated electromagnetic fields are just one of the elements. For example, little attention has been placed on problems with the electric power source. Apparatus for clinical treatment and diagnosis that use electric power sources have come into wide use in hospitals. Hospitals must pay careful attention to all elements of the electromagnetic environment. Herein, I will show examples of measurements and measuring methods for radiated electromagnetic fields, static magnetic fields, and power-source noise, common components of the medical electromagnetic environment. 相似文献
122.
Shimizu T Matsuishi T Iwamoto R Handa K Yoshioka H Kato H Ueda S Hara H Tabira T Mekada E 《The Journal of infectious diseases》2002,185(9):1346-1350
Subacute sclerosing panencephalitis (SSPE) is a slowly progressive and highly lethal disease of the central nervous system. Although the primary cause of SSPE is believed to be persistent infection of neuron and glial cells by a measles virus, the precise mechanism of the progression of this disease has not yet been elucidated. CD9, a member of the tetraspanin family, is expressed in myelin and other nervous tissues. This study detected significant amounts of anti-CD9 antibodies in the cerebrospinal fluid (CSF) of all patients with SSPE included in the study. Anti-CD9 antibodies were also detected in the CSF of some patients with other neurologic disorders, but those patients had lower levels of anti-CD9 antibodies than did the patients with SSPE. The level of anti-CD9 antibodies was elevated and reached a peak that coincided with the appearance of brain atrophy. These findings shed light on a new aspect of the causes and progression of SSPE. 相似文献
123.
Nakajima Ayako Inoue Eisuke Shimizu Yoko Kobayashi Akiko Shidara Kumi Sugimoto Naoki Seto Yohei Tanaka Eiichi Taniguchi Atsuo Momohara Shigeki Yamanaka Hisashi 《Clinical rheumatology》2015,34(3):441-449
Clinical Rheumatology - To clarify the impact of comorbidities on treatment strategies and outcomes in patients with rheumatoid arthritis (RA) using a large observational RA cohort, the presence of... 相似文献
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Mitsutoshi Kimura Kan Nawata Osamu Kinoshita Haruo Yamauchi Yasuhiro Hoshino Masaru Hatano Eisuke Amiya Koichi Kashiwa Miyoko Endo Yukie Kagami Mariko Nemoto Minoru Ono 《Journal of artificial organs》2017,20(4):311-317
Continuous flow left ventricular assist device (CF-LVAD) therapy has improved the survival of patients with advanced heart failure. However, the readmission rate of CF-LVAD patients is still relatively high. A total of 90 patients who received CF-LVADs between April 2011 and March 2016 at our institute and were discharged home were analyzed retrospectively. They were followed up through March 2017. Clinical data, including frequency, length and etiology of readmission, were obtained from medical records. The mean observation period after initial discharge was 713 ± 322 days. In total, 73 patients (81%) had 236 readmissions, 214 unplanned and 22 planned. The overall and unplanned readmission rates were 1.34 and 1.22 per patient-year, respectively. The rate of freedom from unplanned first readmission at 1 year after initial discharge was 39%. The median interval between the previous hospital discharge and first and second readmissions was 311 and 213 days, respectively (log-rank test, p = 0.117). The rate of readmission after more than three readmissions was significantly higher than that of first or second readmission (log-rank test, p < 0.001). The most common etiology of readmission was driveline infection (DLI) (36%), followed by stroke (9%). The median length of hospital stay due to DLI was 23 days. The patients with repeated unplanned readmissions had significantly lower EuroQol 5 dimensions questionnaire utility score than those with no or just one readmission. Readmission was common in CF-LVAD patients, and the most common etiology of readmissions was DLI. The interval to the next readmission seemed shorter for patients with repeated readmissions. 相似文献
127.
Masahiro Nishida Ryo Kosaka Osamu Maruyama Takashi Yamane Akio Shirasu Eisuke Tatsumi Yoshiyuki Taenaka 《Journal of artificial organs》2017,20(1):26-33
A long-term durability test was conducted on a newly developed axial-flow ventricular assist device (VAD) with hydrodynamic bearings. The mock circulatory loop consisted of a diaphragm pump with a mechanical heart valve, a reservoir, a compliance tank, a resistance valve, and flow paths made of polymer or titanium. The VAD was installed behind the diaphragm pump. The blood analog fluid was a saline solution with added glycerin at a temperature of 37 °C. A pulsatile flow was introduced into the VAD over a range of flow rates to realize a positive flow rate and a positive pressure head at a given impeller rotational speed, yielding a flow rate of 5 L/min and a pressure of 100 mmHg. Pulsatile flow conditions were achieved with the diastolic and systolic flow rates of ~0 and 9.5 L/min, respectively, and an average flow rate of ~5 L/min at a pulse rate of 72 bpm. The VAD operation was judged by not only the rotational speed of the impeller, but also the diastolic, systolic, and average flow rates and the average pressure head of the VAD. The conditions of the mock circulatory loop, including the pulse rate of the diaphragm pump, the fluid temperature, and the fluid viscosity were maintained. Eight VADs were tested with testing periods of 2 years, during which they were continuously in operation. The VAD performance factors, including the power consumption and the vibration characteristics, were kept almost constant. The long-term durability of the developed VAD was successfully demonstrated. 相似文献
128.
Kazuma Date Takashi Nishimura Mamoru Arakawa Yoshiaki Takewa Satoru Kishimoto Akihide Umeki Masahiko Ando Toshihide Mizuno Tomonori Tsukiya Minoru Ono Eisuke Tatsumi 《Journal of artificial organs》2017,20(1):18-25
Continuous-flow left ventricular assist devices (LVADs) have improved the prognosis of end-stage heart failure. However, continuous-flow LVADs diminish pulsatility, which possibly result in bleeding, aortic insufficiency, and other adverse effects. We previously developed a novel control system for a continuous-flow LVAD (EVAHEART®; Sun Medical), and demonstrated that we could create sufficient pulsatility by increasing its rotational speed (RS) in the systolic phase (Pulsatile Mode) in the normal heart model. Here, we aimed to evaluate differences between systolic assist with advanced and delayed loads by shifting the timing of increased RS. We implanted EVAHEART in six goats (55.3 ± 4.3 kg) with normal hearts. We reduced their heart rates to <60 bpm using propranolol and controlled the heart rates at 80 and 120 bpm using ventricular pacing. We shifted the timing of increasing RS from ?60 to +60 ms in the systolic phase. We found significant increases in all the following parameters when assessments of delayed timing (+60 ms) were compared with assessments of advanced timing (?60 ms): pulse pressure, mean dP/dt max of aortic pressure, and energy-equivalent pulse pressure. During continuous-flow LVAD support, pulsatility can be controlled using a rotary pump. In particular, pulsatility can be shifted by delaying increased RS. 相似文献
129.
Osteoclast differentiation factor is a ligand for osteoprotegerin/osteoclastogenesis-inhibitory factor and is identical to TRANCE/RANKL
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Hisataka Yasuda Nobuyuki Shima Nobuaki Nakagawa Kyoji Yamaguchi Masahiko Kinosaki Shin-ichi Mochizuki Akihiro Tomoyasu Kazuki Yano Masaaki Goto Akihiko Murakami Eisuke Tsuda Tomonori Morinaga Kanji Higashio Nobuyuki Udagawa Naoyuki Takahashi Tatsuo Suda 《Proceedings of the National Academy of Sciences of the United States of America》1998,95(7):3597-3602
Osteoclasts, the multinucleated cells that resorb bone, develop from hematopoietic cells of monocyte/macrophage lineage. Osteoclast-like cells (OCLs) are formed by coculturing spleen cells with osteoblasts or bone marrow stromal cells in the presence of bone-resorbing factors. The cell-to-cell interaction between osteoblasts/stromal cells and osteoclast progenitors is essential for OCL formation. Recently, we purified and molecularly cloned osteoclastogenesis-inhibitory factor (OCIF), which was identical to osteoprotegerin (OPG). OPG/OCIF is a secreted member of the tumor necrosis factor receptor family and inhibits osteoclastogenesis by interrupting the cell-to-cell interaction. Here we report the expression cloning of a ligand for OPG/OCIF from a complementary DNA library of mouse stromal cells. The protein was found to be a member of the membrane-associated tumor necrosis factor ligand family and induced OCL formation from osteoclast progenitors. A genetically engineered soluble form containing the extracellular domain of the protein induced OCL formation from spleen cells in the absence of osteoblasts/stromal cells. OPG/OCIF abolished the OCL formation induced by the protein. Expression of its gene in osteoblasts/stromal cells was up-regulated by bone-resorbing factors. We conclude that the membrane-bound protein is osteoclast differentiation factor (ODF), a long-sought ligand mediating an essential signal to osteoclast progenitors for their differentiation into osteoclasts. ODF was found to be identical to TRANCE/RANKL, which enhances T-cell growth and dendritic-cell function. ODF seems to be an important regulator in not only osteoclastogenesis but also immune system. 相似文献
130.