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121.
Winters SJ Wang C Abdelrahaman E Hadeed V Dyky MA Brufsky A 《Journal of andrology》2006,27(4):560-564
Inhibin-B is a heterodimeric glycoprotein produced by Sertoli cells. Although inhibin-B levels are low when seminiferous tubules are damaged, studies in normal monkeys reveal that inhibin-B levels also correlate positively with Sertoli cell number. In this study, we measured inhibin-B levels in healthy young adult men aged 18-24 years and in prepubertal boys aged 5-9 years in relation to body mass index (BMI). Inhibin-B levels declined with increasing obesity in young adult men; values were 26% lower in men who were obese compared to normal-weight men. Sex hormone-binding globulin and total testosterone, but not free testosterone, were also lower with increasing BMI; serum follicle-stimulating hormone and luteinizing hormone levels were unaffected by obesity. In prepubertal boys, by contrast, inhibin-B was unaffected by obesity. We propose that reduced levels of inhibin-B indicate that obese men have fewer Sertoli cells than men of normal weight. Moreover, normal values in obese prepubertal boys suggest that the effect of obesity on inhibin-B is established during puberty. Finally, because each Sertoli cell is thought to support a finite number of germ cells, fewer Sertoli cells in obesity may predispose to a lower sperm count in adulthood. We speculate that the escalating prevalence of obesity and insulin resistance among adolescents might negatively influence male reproductive function for the next generation. 相似文献
122.
123.
The objective of this controlled pilot study was to determine if mRNA coding for interleukin-5 (IL-5), a cytokine that promotes eosinophil differentiation, growth, and migration, could be detected in three T-cell lymphomas that were infiltrated extensively by eosinophils. To detect mRNA coding for IL-5, we performed an RNA polymerase chain reaction on mRNA extracted from three T-cell lymphomas with eosinophilia and from 29 positive and negative validation controls. Using this procedure, we detected a 293-base pair, IL-5-specific amplification product in the three cases of T-cell lymphoma with eosinophilia and in 11 of 12 positive validation controls, including 10 cases of Hodgkin's disease with eosinophilia. IL-5 mRNA was not detectable in the 17 negative validation controls. This preliminary study suggests that IL-5 mRNA is detectable by polymerase chain reaction in three cases of T-cell lymphoma with eosinophilia. © 1993 Wiley-Liss, Inc. 相似文献
124.
Tobacco agar, a new medium for differentiating Candida dubliniensis from Candida albicans 总被引:2,自引:0,他引:2 下载免费PDF全文
Isolates of Candida dubliniensis may be misidentified as Candida albicans in microbiological laboratories if only the germ tube and/or the chlamydospore test is used for identification to the species level. In this study, we have evaluated the efficacy of tobacco agar for the differentiation of C. dubliniensis from C. albicans. On this medium at 28 degrees C, all 30 C. dubliniensis isolates produced yellowish-brown colonies with hyphal fringes and abundant chlamydospores, whereas 54 C. albicans isolates formed smooth, white-to-cream-colored colonies with no chlamydospore production. This medium provides a simple tool for presumptive differentiation of C. dubliniensis from C. albicans. 相似文献
125.
Melissa Butt Eiman Khesroh Jocelyn Simmers Ann M. Rogers Matthew F. Helm Andrea Rigby 《Surgery for obesity and related diseases》2021,17(7):1302-1309
BackgroundBariatric surgery rates are increasing in tandem with obesity in the United States. patients after surgery bariatric can lose up to or more than one-third of their excess weight within the first year. This sudden loss of weight can lead to skin redundancy and increased susceptibility to dermatological issues. There is a paucity of literature addressing the issue of skin redundancy and associated factors following bariatric surgery.ObjectivesTo evaluate the prevalence and severity of dermatological concerns among postbariatric surgery patients and assess the impact of these issues on patients’ quality of life.SettingSurgical Weight Loss Clinic at an academic medical center in south-central Pennsylvania.MethodsA cross-sectional survey was administered from September 9 to November 30, 2020 to adult postoperative patients. Data were collected via self-report questionnaires with a retest issued approximately 72 hours later. The survey included questions regarding occurrences of skin disturbances and the Dermatology Life Quality Index. All analyses were conducted using SAS version 9.4.ResultsA total of 575 patients were invited to participate, with 103 participating and 69 completing the retest. The health questionnaire indicated that 69.6% of patients had challenges with skin rashes or irritation due to loose skin; 80.6% were interested in having skin removal surgery; and only 5.8% were referred to a dermatologist for their concerns.ConclusionThe presence of skin concerns was associated with impaired HRQOL among postbariatric patients. This suggests a need to further educate the bariatric interdisciplinary team to evaluate the impacts of skin pathology on postbariatric patients. 相似文献
126.
Yasser Emad Safaa Sayed Ghada S. El-Azkalany Hussein S. El-Fishawy Eiman Abd El Latif Amal H. Eissa 《The Egyptian Rheumatologist》2018,40(1):51-54
Aim of the work
To assess the role of serum anti-annexin V antibodies in Beh?et’s disease (BD) patients in relation to disease manifestations and activity.Patients and methods65 BD patients and 30 matching controls were included. Disease activity was estimated by the Behçet Disease Current Activity Form (BDCAF). Serum IgG anti-annexin V antibodies titre was measured using the enzyme-linked immunosorbent assay.ResultsThe patients’ age was 36.1 ± 8.5 years and disease duration 7.2 ± 5.2 years; 56 males and 9 females. The serum anti-annexin V antibodies level was significantly increased in the BD patients (50.9 ± 12.9 AU/ml) compared to the control (7.3 ± 3.1 AU/ml) (p < 0.0001). Serum anti-annexin V antibodies were significantly increased in BD patients with ocular involvement, skin lesions and neuro-Behcet’s compared to those without (p = 0.02, p = 0.004 and p = 0.002 respectively). Levels were comparable between those with uveitis, vitrous cells, retinal vasculitis, conjunctivitis and hypopyon and those without (p = 0.12, p = 0.22, p = 0.9, p = 0.67, p = 0.79 and p = 0.46 respectively). While those with xerophthalmia had a significantly higher level of anti-annexin V antibodies (60.6 ± 5.7 AU/ml) compared to those without (50.2 ± 13.1 AU/ml) (p = 0.02). The anti-annexin V antibodies significantly correlated with the BDCAF (r = 0.41, p = 0.001) and age (r = 0.43, p < 0.0001) but not with the disease duration (r = 0.22, p = 0.08), steroid dose (r = ?0.21, p = 0.09) or laboratory investigations. On regression analysis, only the age would predict the anti-annexin V antibodies level (p = 0.02) while the BDCAF would not (p = 0.33).ConclusionThere is a role of apoptosis in the pathogenesis of BD with special relation to the ocular, cutaneous and neurological manifestations and a possible link to the disease activity. 相似文献127.
Field evaluation of a rota- and adenovirus immunochromatographic assay using stool samples from children with acute diarrhea in Ghana 下载免费PDF全文
Weitzel T Reither K Mockenhaupt FP Stark K Ignatius R Saad E Seidu-Korkor A Bienzle U Schreier E 《Journal of clinical microbiology》2007,45(8):2695-2697
We evaluated the Rida Quick rotavirus/adenovirus Combi rapid immunochromatographic test (ICT) under field conditions with Ghanaian children with acute diarrhea. Compared to PCR results, sensitivities and specificities were 75% and 95% for rotavirus and 22% and 84% for adenovirus. In resource-poor settings, ICTs may help to overcome difficulties in the diagnosis of rotavirus infection. 相似文献
128.
Ahmet Afşin Oktay Halis Kaan Akturk Kerim Esenboğa Fahad Javed Nichole M. Polin Eiman Jahangir 《Current problems in cardiology》2018,43(3):68-110
Diabetes mellitus (DM) has become a public health problem worldwide, and it has large implications for cardiovascular disease (CVD). In this article, we discuss the etiology and pathophysiology of CVD in DM including the effects of abnormal glucose homeostasis, genetic factors, epigenetics, apoptosis, common pathophysiological mechanisms shared by both DM and CVD, and contributions of other comorbidities. We then cover the pathogenesis of both atherosclerotic disease and cardiomyopathy in relation to DM. Finally, we discuss the prevention of heart disease in DM with a focus on hypertension and dyslipidemia management, weight loss, lifestyle changes, antiplatelet therapy, and glycemic control. 相似文献
129.
Previous investigators have not described some of the new anatomic variations or provided quantitative and analytical data of the arterial anatomy of the lips in as much depth as in this study. Dissections of 14 different facial sides of cadavers were done. Through investigating the arterial supply of the upper and lower lips, measurements were performed and statistically analyzed. The main arterial supply of the upper lip was from the superior labial artery (SLA, mean external diameter, 1.8 mm [SD, 0.74 mm]); in addition, the subalar and septal branches contributed to its vascularization. The origin of the SLA was above the labial commissure in 78.6%. The subalar branch was not found but replaced by the alar artery that arose from the infraorbital artery in 1 specimen. The main arterial supply of the lower lip was derived from 3 branches of the facial artery, the inferior labial artery (mean external diameters, 1.4 mm [SD, 0.31 mm]) and the horizontal and vertical labiomental arteries. The inferior labial artery originated mostly below the labial commissure in 42.9% and formed a common trunk with the SLA in 28.6%. The horizontal labiomental artery was present in all, but vertical labiomental artery was absent in 21.4% of specimens. Overall, observed anatomic variations were classified into types I to VIII. Significant relations between the demographic variables and measured parameters were reported including the correlation coefficient among evaluated parameters. In conclusion, this study provides various information that aids in creating new flaps and supports the vascular base for clinical procedures in reconstructive surgery of the lip. 相似文献
130.
Azza Ahmed Aboul Enein Nermeen Ahmed El Desoukey Eiman Abdel Wahab Hussein Mona Hamdi Nada Adnan Jamjom 《Transfusion and apheresis science》2013,48(2):213-218
BackgroundThe aim of the work was to detect the presence of anti-human leukocyte antigens (anti-HLAs) class I and II antibodies in sera of multitransfused aplastic anemia pediatric patients using two different techniques. The effect of the implemented transfusion practice on the frequency of these antibodies was studied as well as their effect on the patient’s clinical condition.MethodsFlowcytometry panel reactive antibodies (FlowPRAs) for HLA class I and II were determined and compared to the results obtained by Complement-dependent-cytotoxicity (CDC) assay.ResultsOver the past 3 years, 20 aplastic anemia patients received leukoreduced blood components, 5/20 patients received leukoreduced products exclusively throughout their disease (group1), 15/20 patients had received non-leukoreduced components previously (group2). None of the patients in group1 was FlowPRA positive. Six patients from group2 (40%) were FlowPRA positive, only four out of these six patients showed positive CDC test. Positive and negative predictive values of CDC were 44.4 and 81.4% respectively, with 65% accuracy. Platelet refractoriness was encountered in 13/20 patients; only 3 out of these 13 patients (23%) were FlowPRA I positive (38 ± 18%). One refractory patient died from intracranial hemorrhage. His FlowPRA I was 65.7% and CDC assay failed to detect it.ConclusionLeukoreduction of blood components minimizes the incidence of HLA alloimmunization. Further investigations for other immune causes of platelet refractoriness are recommended. FCM is a simple and reliable technique for detection of anti-HLA antibodies, while CDC assay lacks sensitivity and specificity. 相似文献