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Kazuhiko Nakamura Tetsuhide Ito Kazuhiro Kotoh Eikichi Ihara Haruei Ogino Tsutomu Iwasa Yoshimasa Tanaka Yoichiro Iboshi Ryoichi Takayanagi 《Clinical journal of gastroenterology》2012,5(1):1-8
Inflammatory bowel disease (IBD) is frequently associated with extraintestinal manifestations such as hepatopancreatobiliary
manifestations (HPBMs), which include primary sclerosing cholangitis (PSC), pancreatitis, and cholelithiasis. PSC is correlated
with IBD, particularly ulcerative colitis (UC); 70–80% of PSC patients in Western countries and 20–30% in Japan have comorbid
UC. Therefore, patients diagnosed with PSC should be screened for UC by total colonoscopy. While symptoms of PSC-associated
UC are usually milder than PSC-negative UC, these patients have a higher risk of colorectal cancer, particularly in the proximal
colon. Therefore, regular colonoscopy surveillance is required regardless of UC symptoms. Administration of 5-aminosalicylic
acid or ursodeoxycholic acid may prevent colorectal cancer and cholangiocarcinoma. While PSC is diagnosed by diffuse multifocal
strictures on cholangiography, it must be carefully differentiated from immunoglobulin G4 (IgG4)-associated cholangitis, which
shows a similar cholangiogram but requires different treatment. When PSC is suspected despite a normal cholangiogram, the
patient may have small-duct PSC, which requires a liver biopsy. IBD patients have a high incidence of acute and chronic pancreatitis.
Most cases are induced by cholelithiasis or medication, although some patients may have autoimmune pancreatitis (AIP), most
commonly type 2 without elevation of serum IgG4. AIP should be accurately identified based on characteristic image findings,
because AIP responds well to corticosteroids. Crohn’s disease is frequently associated with gallstones, and several risk factors
are indicated. HPBMs may influence the management of IBD, therefore, accurate diagnosis and an appropriate therapeutic strategy
are important, as treatment depends upon the type of HPBM. 相似文献
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Helicobacter pylori infection in children with chronic idiopathic thrombocytopenic purpura 总被引:1,自引:0,他引:1
Hiroko Hayashi Masumi Okuda Noriyuki Aoyagi Megumi Yoshiyama Eikichi Miyashiro Shinji Kounami Norishige Yoshikawa 《Pediatrics international》2005,47(3):292-295
BACKGROUND: Recently a high prevalence of Helicobacter pylori infection has been reported in adult patients with chronic idiopathic thrombocytopenic purpura (cITP). Furthermore, after H. pylori eradication therapy in such patients, their platelet counts have been observed to increase, suggesting that H. pylori may be a causative agent of adult cITP. However, there have been only a few reports of children with cITP. The purpose of the present paper was to examine the association between H. pylori infection and cITP in Japanese children. METHODS: Helicobacter pylori stool antigens (HpSA) were measured and the prevalence of H. pylori infection was determined in 10 children with cITP. RESULTS: Helicobacter pylori infection was found in only two of the subjects. In a boy, the urea breath test (UBT) was also positive and the patient received eradication therapy using amoxicillin, clarithromycin, and lansoprazole for 1 week. The therapy was successful and the patient's platelet count increased. The response was maintained throughout more than 1 year of follow up. CONCLUSIONS: The prevalence of H. pylori infection in children with cITP is not high. However, the platelet count increased after eradication therapy in a boy with cITP. It is suggested that the eradication of H. pylori infection would be valuable in children, as well as in adults, with cITP. 相似文献
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Li W Murai Y Okada E Matsui K Hayashi S Horie M Takano Y 《Pathology international》2002,52(3):234-238
A modified western blotting protocol was developed to increase the binding specificity of antigens and antibodies, using intermittent microwave irradiation (IMWI) with seven antibodies and two cell lines. The method was based on IMWI of the blotting membrane in the immunoblotting step using 5% skim milk as the diluting buffer. For some antibodies against p53, CDK4 and cyclinE, there were no distinct differences between the IMWI(+) and IMWI(-) counterparts; but improvement over the standard protocol was noted in both. For some antibodies, such as the polyclonal antibody against tubulin and the monoclonal antibodies against beta-tubulin, cyclinA and cyclinB1 (which were otherwise difficult to obtain good results with), IMWI was extremely effective, resulting in clear, specifically binding bands and a clean background. Moreover, the times were reduced from 8 to 3 h. Both the IMWI(+) and IMWI(-) protocols can be applied as simple, rapid and highly specific detection techniques for applications with various antigens, reducing background 'noise' to a minimum. 相似文献
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