全文获取类型
收费全文 | 1207篇 |
免费 | 65篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 59篇 |
妇产科学 | 21篇 |
基础医学 | 119篇 |
口腔科学 | 38篇 |
临床医学 | 55篇 |
内科学 | 191篇 |
皮肤病学 | 10篇 |
神经病学 | 144篇 |
特种医学 | 14篇 |
外科学 | 187篇 |
综合类 | 5篇 |
预防医学 | 170篇 |
眼科学 | 10篇 |
药学 | 71篇 |
肿瘤学 | 174篇 |
出版年
2023年 | 8篇 |
2022年 | 9篇 |
2021年 | 15篇 |
2020年 | 27篇 |
2019年 | 22篇 |
2018年 | 25篇 |
2017年 | 19篇 |
2016年 | 21篇 |
2015年 | 24篇 |
2014年 | 25篇 |
2013年 | 43篇 |
2012年 | 75篇 |
2011年 | 81篇 |
2010年 | 44篇 |
2009年 | 37篇 |
2008年 | 82篇 |
2007年 | 76篇 |
2006年 | 107篇 |
2005年 | 75篇 |
2004年 | 72篇 |
2003年 | 78篇 |
2002年 | 84篇 |
2001年 | 12篇 |
2000年 | 14篇 |
1999年 | 18篇 |
1998年 | 16篇 |
1997年 | 18篇 |
1996年 | 10篇 |
1995年 | 14篇 |
1994年 | 12篇 |
1993年 | 11篇 |
1992年 | 10篇 |
1991年 | 4篇 |
1990年 | 4篇 |
1989年 | 7篇 |
1988年 | 6篇 |
1986年 | 5篇 |
1985年 | 6篇 |
1983年 | 6篇 |
1982年 | 10篇 |
1980年 | 5篇 |
1979年 | 3篇 |
1978年 | 2篇 |
1977年 | 3篇 |
1974年 | 3篇 |
1972年 | 4篇 |
1967年 | 2篇 |
1966年 | 3篇 |
1965年 | 2篇 |
1964年 | 2篇 |
排序方式: 共有1275条查询结果,搜索用时 445 毫秒
11.
12.
Reference Values for Echocardiography in Middle‐Aged Population: The Cardiovascular Risk in Young Finns Study
下载免费PDF全文
![点击此处可从《Echocardiography (Mount Kisco, N.Y.)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Saku Ruohonen Ph.D Juha W. Koskenvuo M.D. Ph.D. Maria Wendelin‐Saarenhovi M.D. Ph.D. Mikko Savontaus M.D. Ph.D. Mika Kähönen M.D. Ph.D. Tomi Laitinen M.D. Ph.D. Terho Lehtimäki M.D. Ph.D. Eero Jokinen M.D. Ph.D. Jorma Viikari M.D. Ph.D. Markus Juonala M.D. Ph.D. Leena Taittonen M.D. Ph.D. Päivi Tossavainen M.D. Ph.D. Merja Kallio M.D. Ph.D. Jeroen J. Bax M.D. Ph.D. Olli Raitakari M.D. Ph.D. 《Echocardiography (Mount Kisco, N.Y.)》2016,33(2):193-206
13.
14.
Inequality in oral health‐related quality of life before and after a major subsidization reform
下载免费PDF全文
![点击此处可从《European journal of oral sciences》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Eero Raittio Satu Lahti Urpo Kiiskinen Sari Helminen Arpo Aromaa Anna L. Suominen 《European journal of oral sciences》2015,123(4):267-275
In Finland, a dental subsidization reform, implemented in 2001–2002, abolished age restrictions on subsidized dental care. We investigated income‐related inequality in oral health‐related quality of life (OHRQoL) and its determinants among adult Finns before and after the reform. Three cross‐sectional postal surveys, focusing on perceived oral health and the use of dental services among people born before 1971, were conducted in 2001 (n = 2,046), 2004 (n = 1,728), and 2007 (n = 1,560). Five measures, based on the Oral Health Impact Profile‐14, were used as indicators of OHRQoL. Income‐related inequality and associated factors were analysed using the concentration index and its decomposition. Prevalence, extent, and severity of oral health impacts were slightly lower in 2007 than in 2001. The oral health impacts were concentrated, at all study time points, among individuals with lower income. Most of the inequality was related to self‐perceived general health, tooth loss, and income. Contributions of time since the last dental visit and satisfaction with the last treatment period to the inequality decreased from 2001 to 2007. However, the contributions of these factors were already small (10–20%) in 2001. In general, OHRQoL improved slightly; however, no clear or dramatic change in inequality in OHRQoL was seen after the reform. 相似文献
15.
Vahid Mehrpour Travis Meyer Eero P. Simoncelli Nicole C. Rust 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(18)
Memories of the images that we have seen are thought to be reflected in the reduction of neural responses in high-level visual areas such as inferotemporal (IT) cortex, a phenomenon known as repetition suppression (RS). We challenged this hypothesis with a task that required rhesus monkeys to report whether images were novel or repeated while ignoring variations in contrast, a stimulus attribute that is also known to modulate the overall IT response. The monkeys’ behavior was largely contrast invariant, contrary to the predictions of an RS-inspired decoder, which could not distinguish responses to images that are repeated from those that are of lower contrast. However, the monkeys’ behavioral patterns were well predicted by a linearly decodable variant in which the total spike count was corrected for contrast modulation. These results suggest that the IT neural activity pattern that best aligns with single-exposure visual recognition memory behavior is not RS but rather sensory referenced suppression: reductions in IT population response magnitude, corrected for sensory modulation.Under the right conditions, we are very good at remembering the images that we have seen: we can remember thousands of images after viewing each only once and only for a few seconds (1, 2). How our brains support this remarkable ability, often called “visual recognition memory” (3), is not well understood. The most prominent proposal to date suggests that memories about whether images have been encountered before are signaled in high-level visual brain areas such as inferotemporal cortex (IT) and perirhinal cortex via adaptation-like reductions of the population response to repeated as compared to novel stimuli, a phenomenon referred to as repetition suppression (RS) (4–9). Repetition suppression exhibits the primary attributes needed to account for the vast capacity of single-exposure visual memory behavior: response decrements in subsequent exposures are selective for image identity (even after viewing an extensive sequence of other images), and last for several minutes to hours (5, 6, 10). RS has also been shown to account for behavior in an image recognition memory task: a linear decoder with positive weights can predict single-exposure visual recognition memory behavior from neural responses in IT cortex (10).Despite the fact that the RS hypothesis is consistent with available evidence, it seems likely to be too simplistic an explanation for visual recognition memory encoding. In particular, it is well known that sensory neurons such as those of IT cortex are modulated not only by image memory, but also by stimulus properties such as image contrast (11). It is thus unclear whether and how these stimulus-induced effects interfere with judgments of whether images are novel or have been encountered before, and if they do not, how image memory can be decoded from neural responses in a way that disambiguates it from changes in these stimulus properties. To investigate this, we measured behavioral and neural responses of monkeys trained to report whether images were novel or repeated while disregarding image contrast (Fig. 1A).Open in a separate windowFig. 1.Visual memory behavior. (A) The contrast-invariant, single-exposure visual memory task. The monkeys viewed a sequence of images and reported whether they were novel (never seen before) or repeated (seen exactly once) while ignoring randomized changes in contrast. Monkeys were trained to saccade to one of two response targets to indicate their choice (red arrows). Images were repeated with a randomly chosen delay between the first and repeated presentation (“n-back”). (B) Images were displayed at one of two contrast levels, yielding two conditions for novel images, high (H) and low (L), and four conditions for repeated images: HH (repeated H preceded by novel H), LL (repeated L preceded by novel L), HL (repeated L preceded by novel H), and LH (repeated H preceded by novel L). The four repeated conditions were organized into same-contrast and mixed-contrast groups depending on whether the initial and repeated presentations were at the same or different contrasts, respectively. (C) Behavioral performance for the data pooled across monkeys in the task, where small black dots indicate average performance for an individual session and large colored dots indicate the average performance across sessions. A measure of contrast invariance, I, was computed as the ratio of the variance across contrast conditions and the variance with respect to the maximally contrast-modulated pattern after taking overall performance into account, subtracted from 1 (SI Appendix, SI Methods). Insets illustrate the expected behavioral pattern with minimal (I = 0) and maximal (I = 1) contrast invariance. 相似文献
16.
17.
Hypertension and high serum cholesterol level are important risk factors for atherosclerosis and coronary heart disease. In
the present study we tested the hypothesis whether high sodium intake, when given in combination with Western type high-fat
diet, induces endothelial dysfunction and promotes atherosclerosis. Furthermore, the role and enzyme sources of increased
oxidative stress were examined. Low-density lipoprotein receptor-deficient mice (LDLR−/−) and control C57Bl/6 mice received either high-fat, normal-sodium diet (fat 18% and cholesterol 0.5%; NaCl 0.7%; w/w) or
high-fat, high-sodium diet (7% NaCl w/w) for 12 weeks. Superoxide formation was assessed by lucigenin enhanced chemiluminescence,
endothelial functions were examined ex vivo, and atherosclerotic lesions from the aorta were assessed by light microscopy.
High-fat, high-sodium diet increased systolic blood pressure in LDLR−/− mice but not in C57Bl/6 mice, whereas it induced cardiac hypertrophy in both mouse strains. Dietary combination of fat and
sodium induced endothelial dysfunction in LDLR−/− mice. Preincubation with a superoxide scavenger Tiron normalized endothelial dysfunction, whereas the hydrogen peroxide scavenger
catalase did not alter endothelial function. High sodium intake induced superoxide formation in LDLR−/− mice on high-fat diet. Stimulation of muscarinic receptors in the endothelial cells by acetylcholine increased superoxide
generation, whereas preincubation with the nitric oxide synthase (NOS) inhibitor L-arginine methyl ester or endothelium removal
reduced superoxide production. Inhibition of nicotinamide adenine dinucleotide phosphate (NADPH)-oxidase by apocynin decreased
vascular superoxide formation whereas the xanthine oxidase inhibitor oxypurinol did not significantly affect oxidative stress
in LDLR−/− mice. In conclusion, the detrimental effects of dietary sodium on endothelial function and progression of atherosclerosis
in LDLR−/− mice on high-fat diet are mediated by increased ROS formation mainly through uncoupled NOS and NADPH oxidase. The present
study also underscores the importance of superoxide and endothelial NOS uncoupling in the pathogenesis of endothelial dysfunction. 相似文献
18.
Justo Lorenzo Bermejo Eero Pukkala Tom B. Johannesen Jan Sundquist Kari Hemminki 《British journal of haematology》2014,164(5):675-683
Survival after non‐Hodgkin lymphoma (NHL) has increased thanks to improved treatment but NHL survivors have an increased risk of second neoplasms. The assessment of cancer risk patterns after NHL may help to quantify the late side‐effects of therapy. Poisson regression was used to estimate relative risks (RRs) and absolute incidence rates for nine solid tumours based on a nationwide cohort of 60 901 NHL survivors from Finland, Norway and Sweden. Patients were diagnosed between 1980 and 2006 and developed 6815 s neoplasms. NHL patients showed an increased risk of each of the nine investigated cancer sites: prostate and pancreas (both RRs 1·28), breast (1·37), colorectum (1·48), urinary bladder (1·52), stomach and lung (both RRs 1·87), skin (melanoma 2·27) and kidney (2·56). The RRs showed a U‐shaped relationship with time after NHL for all nine‐second cancer types. NHL diagnosis early in life was a risk factor for the development of second cancers with the exception of melanoma, but a risk excess was even observed in patients diagnosed with NHL at age 80+ years. The present study provides accurate estimates on the adverse late effects of NHL therapy, which should guide the establishment of cancer prevention strategies in NHL survivors. 相似文献
19.