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61.
Antonio Grande-Trillo Carmen Baliellas Laura Lladó Carlos Casasnovas Joaquín V. Franco-Baux Laura Gracia-Sánchez Miguel Á. Gómez-Bravo Emma González-Vilatarsana Luis Caballero-Gullón Eduardo Echeverri José González-Costello 《American journal of transplantation》2021,21(1):372-381
Domino liver transplantation (DLT) has been used widely in patients with hereditary amyloid transthyretin (ATTR) amyloidosis. New-onset polyneuropathy in recipients of DLT has been reported, but there are few cases of cardiac involvement reported. We aimed to perform a cross-sectional study for ATTR amyloidosis with cardiomyopathy (ATTR-CM) in DLT recipients. We evaluated 23 living DLT recipients a median of 9 years since DLT at 2 referral centers with a systematic cardiac evaluation, including bone scintigraphy. Median age was 72 years, 91% had hypertension, 35% had diabetes mellitus, 67% had chronic renal failure, and 8 patients (35%) developed new-onset polyneuropathy. Only 13% had a normal electrocardiogram and a normal echocardiography, and most of them showed some conduction disturbance or increase in left ventricular wall thickness, but only 1 patient with a Glu89Lys mutation developed ATTR-CM diagnosed by bone scintigraphy and endomyocardial biopsy. None of the recipients of a DLT with Val30Met mutation showed cardiac involvement by bone scintigraphy. In conclusion, DLT from Val30Met donors seems to be safe regarding the development of ATTR-CM. Evaluation of cardiomyopathy in DLT recipients is challenging due to concomitant comorbidities and in this context, bone scintigraphy can be helpful to evaluate ATTR-CM. 相似文献
62.
Juan Carlos Sebasti n-Tom s Aleix Mart nez-P rez El as Mart nez-L pez Nicola de Angelis Marcos G mez Ruiz Eduardo Garc a-Granero 《World journal of gastrointestinal surgery》2021,13(8):834-847
Total mesorectal excision (TME) is the standard surgical treatment for the curative radical resection of rectal cancers. Minimally invasive TME has been gaining ground favored by the continuous technological advancements. New procedures, such as transanal TME (TaTME), have been introduced to overcome some technical limitations, especially in low rectal tumors, obese patients, and/or narrow pelvis. The earliest TaTME reports showed promising results when compared with the conventional laparoscopic TME. However, recent publications raised concerns regarding the high rates of anastomotic leaks or local recurrences observed in national series. Robotic TaTME (R-TaTME) has been proposed as a novel technique incorporating the potential benefits of a perineal dissection together with precise control of the distal margins, and also offers all those advantages provided by the robotic technology in terms of improved precision and dexterity. Encouraging short-term results have been reported for R-TaTME, but further studies are needed to assess the real role of the new technique in the long-term oncological or functional outcomes. The present review aims to provide a general overview of R-TaTME by analyzing the body of the available literature, with a special focus on the potential benefits, harms, and future perspectives for this novel approach. 相似文献
63.
Eduardo Alarcón-Capel Alberto Ruano-Ravina Juan M. Barros-Dios 《Gaceta sanitaria / S.E.S.P.A.S》2021,35(1):72-80
ObjectiveTo assess the association between exposure to radon and genitourinary cancer in a mining population through a systematic review of the scientific literature.MethodA systematic review of the scientific literature was carried out in MEDLINE (PubMed), combining MeSH (Medical Subject Heading) terms and free terms. We applied a specific scale to assess the quality of the included studies.ResultsWe included 17 studies; all were cohort studies with the exception of one which was a pooling of data. All studies included analysed the relationship between exposure to radon and genitourinary cancer. While some studies point towards an association between radon exposure and genitourinary cancer, especially kidney cancer, others do not find such association.ConclusionsThe included studies showed great heterogeneity. It cannot be concluded that there is an association between exposure to radon and genitourinary cancer. More research is needed on this topic, designing studies with higher statistical power, better control of confounders, and preferably prospective. 相似文献
64.
Carlos Eduardo Rochitte Eduardo Marinho Tassi Afonso Akio Shiozaki 《The International Journal of Cardiac Imaging》1990,6(Z1):46
Abstracts
Role of endomyocardial biopsy in the diagnosis and management of cardiomyopathies 相似文献65.
Pacini Laura Limatola Cristina De Laurenzi Vincenzo Ricci Irene Spinedi Angelo 《Journal of neuro-oncology》1997,31(1-2):141-146
In the human neuroblastoma cell line SK-N-BE(2), arachidonic acid (AA), supplied in the medium at micromolar concentrations, markedly ehnanced [14C]stearic acid (SA) (but not [14C]palmitic acid or [14C]oleic acid) incorporation into phosphatidylinositol (PtdIns). AA failed to stimulate [14C]SA incorporation into PtdIns precursors, namely phosphatidic acid and cytidinediphosphodiacylglycerol; furthermore, enhanced [14C]SA incorporation, brought about by exogenously administered AA, was not restricted to PtdIns tetraenoic species. When cells were pulsed for 1 h with [14C]SA (either in the presence or absence of AA) and then reincubated in AA- and [14C]SA-free medium, a marked loss of radioactivity from PtdIns was observed, that however was restricted to molecular species other than tetraenoic. These results are discussed in the light of possible mechanisms through which PtdIns achieves the 1-stearoyl-2-arachidonoyl configuration. 相似文献
66.
Limatola Cristina Pacini Laura Candi Eleonora Spinedi Angelo 《Journal of neuro-oncology》1997,31(1-2):129-132
Stimulation of SK-N-BE(2) cells with 1 mM carbachol (Cch) elicited phosphoinositide (PPI) hydrolysis and a rapid elevation of cytosolic Ca2+ concentration ([Ca2+]i) from 115 nM to about 500 nM, followed by a plateau around 200 nM. In myo [3H]inositol-labelled cells, Cch-evoked accumulation of [3H]inositol phosphates (IPs) was not affected when [Ca2+]i was clamped at resting by cell loading with 10 M BAPTA/AM; under these conditions, maximal 1,4,5-inositol trisphosphate accumulation was not reduced either. When [Ca2+]i was clamped around 700 nM by cell treatment with 600 nM ionomycin, Cch-evoked [3H]IPs accumulation was enhanced by less than 20%, but it was impaired by a 30% and a 55% after [Ca2+]i reduction to about 70 nM and 35—50 nM, by cell loading with 20 M or 40 M BAPTA/AM, respectively. These results show that, in SK-N-BE(2) cells, Cch-activated PPI-specific phospholipase C is sensitive to [Ca2+]i but it already operates under suboptimal conditions at resting [Ca2+]i. 相似文献
67.
Francisco Cano Angela Delucchi Eduardo Wolff Eugenio Rodriguez Angel Fuentes 《Pediatric nephrology (Berlin, Germany)》1995,9(5):606-608
A 6-month protocol of oral pulse calcitriol was used in nine uraemic children (2–14 years old) on dialysis who presented with renal osteodystrophy. Calcitriol was administered twice a week, 4 g per dose for patients over 30 kg and 3g for patients less than 30 kg. Plasma levels of parathyroid hormone, calcium, phosphorus and alkaline phosphatase were carefully controlled during the study. Parathyroid hormone levels decreased by 68% and 56% by the 2nd and 6th months of treatment in seven patients, while they remained unchanged in two patients with focal segmental glomerulosclerosis and massive proteinuria. Eight hypercalcaemic episodes from 77 determinations were observed, all of them recovered after 1 week of vitamin D withdrawal. We conclude that oral calcitriol pulse therapy is a good alternative for renal osteodystrophy in uraemic children. Careful monitoring of plasma parathyroid hormone and calcium is needed during follow-up when using this approach in paediatric patients. 相似文献
68.
Riveros EG 《Annals of nuclear medicine》1999,13(5):367-368
Eight patients were inadvertently administered, and imaged with, 99mTc-labeled MDP which was 45 months expired. Two cases are presented. All patients were subsequently imaged with normal MDP. The images obtained with expired MDP were clinically acceptable. No differences in scan abnormalities were observed compared with normal MDP for any of the patients. None of the patients suffered any side effects attributable to the expired MDP. 相似文献
69.
Oliveira EA Diniz JS Cabral AC Leite HV Colosimo EA Oliveira RB Vilasboas AS 《Pediatric nephrology (Berlin, Germany)》1999,13(9):859-864
With the increasing use of obstetric echography fetal hydronephrosis has been reported more frequently. The purpose of this
study was to identify prognostic factors associated with adverse outcome, such as renal failure and death, in fetal hydronephrosis.
One hundred and forty-eight children with fetal hydronephrosis were admitted, submitted to a systematic protocol, and prospectively
followed. Prognostic factors associated with fetal echography and clinical and laboratory findings on admission were studied.
The median follow-up was 39 months. The analysis was conducted in two steps. In a univariate analysis, variables associated
with adverse outcome were identified by the Kaplan-Meier method. The variables that were significantly associated with adverse
outcome were then included in a multivariate analysis. This analysis, using the multivariate Cox’s model, was performed to
identify variables that were independently associated with a worse prognosis. Only variables that remained independently associated
with adverse outcome were included in the final model. After final adjustment by Cox’s multivariate model, three variables
were identified as independent predictors of adverse outcome: oligohydramnios, prematurity, and glomerular filtration rate
lower than 20 ml/min. Thus, in the presence of oligohydramnios, prematurity, and abnormal renal function, the medical team
must plan appropriate follow-up for infants at health centers prepared to investigate and treat uropathies in newborns.
Received: 24 August 1998 / Revised: 7 December 1998 / Accepted: 11 December 1998 相似文献
70.
Secretory breast carcinoma is a rare tumor originally described in children and adolescent women with a characteristic morphology and a controversial choice of treatment. We report an additional case of a 4-year-old girl with a breast tumor diagnosed as a secretory carcinoma without involvement of the axillary lymph nodes. The therapy consisted of simple mastectomy and low axillary dissection. She presented with a local recurrence near the surgical scar 8 months later, and a wide elliptical excision of the scar and underlying tissue was performed with subsequent radiotherapy of the surgical bed. This tumor has a relatively benign behavior and rarely metastasizes. A literature review revealed only 22 cases of breast carcinoma in childhood and adolescence. ▪ 相似文献