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261.
Lucio Urbani Alessandro Mazzoni Lucia Bindi Gianni Biancofiore Massimo Bisà Luca Meacci Massimo Esposito Roberto Mozzo Piero Colombatto Irene Bianco Tiziana Grazzini Laura Coletti Paolo De Simone Gabriele Catalano Umberto Montin Giovanni Tincani Emanuele Balzano Stefania Petruccelli Paola Carrai Carlo Tascini Francesco Menichetti Fabrizio Scatena Franco Filipponi 《Clinical transplantation》2009,23(6):853-860
Abstract: The aim of the present work was to assess the incidence of neuro‐nephrotoxicity after a single‐staggered dose of calcineurin inhibitors (CI) with different immunosuppressive approaches. From January to December 2006, all liver transplantation (LT) recipients at risk of renal or neurological complications treated with extracorporeal photopheresis (ECP) + mycophenolate mofetil + steroids and staggered introduction of CI (ECP group) were compared with a historical control group on standard CI‐based immunosuppression. The ECP group included 24 patients with a mean model for end‐stage liver disease (MELD) score of 19.9 ± 11.1. The control group consisted of 18 patients with a mean MELD score of 12.5 ± 5.2 (p = 0.012). In the ECP group CI were introduced at a mean of 9.2 ± 6.2 d (4–31 d) after LT. Five patients in the ECP group presented acute neuro‐nephrotoxicity after the first CI administration on post‐transplant d 4, 5, 6, 6, and 14. Overall patient survival at one, six, and 12 months was 100%, 95.8%, and 95.8% in the ECP group vs. 94.4%, 77.7%, and 72.2% in the control group (p < 0.001). In conclusion, we showed that CI toxicity may occur after a single‐staggered dose administration, ECP seems to be a valuable tool for managing CI‐related morbidity regardless of the concomitant immunosuppressive regimen, being associated with a lower mortality rate in the early post‐transplant course. 相似文献
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263.
Di Quirico R Di Tano V Cornacchia R Orfanelli R Leonio L Bindi F 《Il Giornale di chirurgia》2008,29(4):177-179
The Authors describe the utility of comprehensive protocols for the treatment of major burns and the adoption of these for the initial and correct management of burns by prehospital and hospital emergency staff. 相似文献