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排序方式: 共有220条查询结果,搜索用时 15 毫秒
151.
152.
Bovill EG; Soll RF; Lynch M; Bhushan F; Landesman M; Freije M; Church W; McAuliffe T; Davidson K; Sadowski J 《Blood》1993,81(1):77-83
This study investigated the incidences of undercarboxylated (protein induced by vitamin K absence: PIVKA) prothrombin and protein C in 496 neonates across a wide range of gestational ages. These findings are related to vitamin K1 levels (an indicator of cofactor availability) and vitamin K1 epoxide levels (a measure of the efficiency of the hepatic vitamin K cycle). PIVKA protein C was present in at least trace amounts in 27% of infants; whereas, PIVKA prothrombin was present in 7% of infants. PIVKA prothrombin and protein C were present at high plasma concentrations in 2% to 3% of term and preterm neonates and both PIVKA protein C and prothrombin increased with gestational age. Despite elevated plasma concentrations of PIVKA protein C and diminished levels of normally carboxylated protein C, clinical thrombosis was not observed. The mean (+/- SD) vitamin K1 level in the study population was 0.009 +/- 0.02 nmol/L (adult reference interval: 0.3 to 2.6 nmol/L) with no clear relationship between vitamin K1 levels and production of PIVKA protein C or prothrombin. By comparison with adults, the epoxide form of the vitamin comprised an abnormally high proportion of total vitamin K1; this suggests possible inefficiencies in hepatic reductase cycling. 相似文献
153.
van Gameren MM; Willemse PH; Mulder NH; Limburg PC; Groen HJ; Vellenga E; de Vries EG 《Blood》1994,84(5):1434-1441
To define the toxicity profile of recombinant human interleukin-6 (rhIL- 6) and to study its effect on hematopoiesis, biochemical parameters and other cytokines, rhIL-6 was administered in a phase I-II study to 20 patients with breast carcinoma or nonsmall cell lung cancer. RhIL-6 doses were 0.5, 1.0, 2.5, 5.0, 10, and 20 micrograms/kg/d, with at least three patients per dose level. RhIL-6 was administered 24 hours by continuous intravenous infusion followed by subcutaneous (SC) administration for 6 days, partly on an outpatient basis. RhIL-6- related side effects were fever, headache, myalgia, and local erythema. Starting at 2.5 micrograms/kg/d, these side effects were compounded by nausea, reversible increase in liver enzymes, and anemia. Flu-like symptoms were controllable up to and including 10 micrograms rhIL- 6/kg/d with acetaminophen. RhIL-6 increased platelet counts with a decrease in mean platelet volume and increased leukocytes caused by neutrophil, monocyte, and lymphocyte increase, with an increase in T cells and natural killer cells at 1.0 and 2.5 micrograms rhIL-6/kg/d. The reversible anemia was characterized by a decrease in serum iron, and an increase in ferritin and erythropoietin without reticulocytosis. RhIL-6 reduced total cholesterol levels and a dose-related increase of C-reactive protein and serum amyloid A plasma levels was observed. Serum IL-6 levels were increased, especially at 10 and 20 micrograms/kg/d, whereas no change in IL-1 beta and tumor necrosis factor alpha levels was observed. RhIL-6 can be administered with controllable side effects in this setting, up to and including a SC dose of 10 micrograms/kg/d on an outpatient basis, and has a promising stimulating effect on leukopoiesis and thrombopoiesis. 相似文献
154.
Nonsurgical treatment of splenic-artery aneurysms 总被引:4,自引:0,他引:4
Probst P; Castaneda-Zuniga WR; Gomes AS; Yonehiro EG; Delaney JP; Amplatz K 《Radiology》1978,128(3):619
155.
Background
Differences in the management of coronary artery disease between men and women have been reported in the literature. There are few studies of potential inequalities of treatment that arise from a primary care context. This study investigated the existence of such inequalities in the medical management of post myocardial infarction in older patients. 相似文献156.
157.
Research Group EG 《Gynecological endocrinology》2013,29(8):652-654
Objective: Vaginal dystrophy due to hypo-oestrogenism takes advantage of local and systemic oestrogens to balance the vaginal ecosystem and improve tissue hydration. Women who do not accept/tolerate hormone therapy can use intravaginal isoflavones to relieve vaginal dryness. The aim of this study was to investigate the clinical effect of a vaginal gel formulation containing isoflavones compared with no topical treatment in women with vaginal dystrophy. Material and methods: In a multicentre, controlled, parallel-group study, menopausal women with vaginal dystrophy were randomized to vaginal gel (EG) or no topical treatment (NT) for 4 weeks. EG contained isoflavones, Lactobacillus sporogenes, Calendula officinalis extract and lactic acid (Estromineral Gel, Rottapharm-Madaus). All patients received daily oral isoflavones plus L. sporogenes. Clinical evaluations were performed at time 0, 2 and 4 weeks. Results: 186 women were recruited, 103 in the EG group and 83 in the NT group, mean age 53.7 years, postmenopausal for 4.1 years. The severity of itching, burning, vulvovaginal erythema, vaginal dryness and dyspareunia were significantly reduced during EG treatment compared with the NT group. Conclusions: The combination of oral and topical isoflavones was shown to be more effective than oral treatment alone in reducing the problems of postmenopausal vaginal dystrophy. 相似文献
158.
Donald EG Griesdale Mypinder S Sekhon William R Henderson 《Critical care (London, England)》2013,17(1):401
The observational literature suggests that hypernatremia is associated with worse outcomes in patients with traumatic brain injury. In a previous issue of Critical Care, Wells and colleagues add to this literature by failing to show an association between hypernatremia and reduced intracranial pressure. However, we must bear in mind many limitations of observational methods before eliminating hyperosmolar therapy from our armamentarium.In a previous issue of Critical Care, Wells and colleagues [1] report on their retrospective cohort study examining the relationship between serum sodium and intracranial pressure (ICP) with severe traumatic brain injury (TBI). This is an ongoing topic of interest to neurointensivists as hyperosmolar therapy remains a treatment option for elevated ICP [2]. We commend the authors for their contribution to a fundamentally important issue in neurocritical care; however, several issues deserve further discussion.A critical limitation of observational methodology is confounding by indication, which exists when variables associated with exposure are also associated with outcomes in the study base [3]. Clinicians administer hyperosmolar therapy and induce hypernatremia on the basis of measured and unmeasured characteristics of patients. Lack of a formalized TBI protocol, including indications for hypertonic saline (HTS), can exacerbate this bias. For example, clinicians in the study by Wells and colleagues used both boluses and infusions of HTS with a range of administered concentrations (3% versus 7.5%). No attempt was made to adjust for differences in baseline characteristics of patients. Furthermore, although regression is an important method to help reduce bias, several assumptions must be met for the analysis to be valid. Linear regression is predicated upon independence of data. With 1,230 paired sodium and ICP measurements in 81 patients, there is likely to be marked within-subject correlation of data that is not taken into account by this analysis. Consequently, a linear mixed model or other analysis is warranted to specifically model and account for this correlation [4]. Failing to do so limits the interpretability of their results. 相似文献
159.
160.