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921.
922.
Alexander Grundmann BMBCh Chieh-Hsi Wu PhD Marc Hardwick BMBCh J. Kenneth Baillie FRCA PhD Peter J M Openshaw FRCP PhD Malcolm G. Semple FRCPCH PhD Dankmar Böhning PhD Sarah Pett FRACP PhD Benedict D. Michael FRCP PhD Rhys H. Thomas FRCP PhD Ian Galea FRCP PhD for the ISARICC investigators 《Annals of neurology》2023,93(1):88-102
923.
Thomas Williams Nevin John Alberto Calvi Alessia Bianchi Floriana De Angelis Anisha Doshi Sarah Wright Madiha Shatila Marios C. Yiannakas Fatima Chowdhury Jon Stutters Antonio Ricciardi Ferran Prados David MacManus Marie Braisher James Blackstone Olga Ciccarelli Claudia A. M. Gandini Wheeler-Kingshott Frederik Barkhof Jeremy Chataway the UCL MS-STAT investigators 《European journal of neurology》2023,30(9):2769-2780
Background and purpose
There is increasing evidence that cardiovascular risk (CVR) contributes to disability progression in multiple sclerosis (MS). CVR is particularly prevalent in secondary progressive MS (SPMS) and can be quantified through validated composite CVR scores. The aim was to examine the cross-sectional relationships between excess modifiable CVR, whole and regional brain atrophy on magnetic resonance imaging, and disability in patients with SPMS.Methods
Participants had SPMS, and data were collected at enrolment into the MS-STAT2 trial. Composite CVR scores were calculated using the QRISK3 software. Prematurely achieved CVR due to modifiable risk factors was expressed as QRISK3 premature CVR, derived through reference to the normative QRISK3 dataset and expressed in years. Associations were determined with multiple linear regressions.Results
For the 218 participants, mean age was 54 years and median Expanded Disability Status Scale was 6.0. Each additional year of prematurely achieved CVR was associated with a 2.7 mL (beta coefficient; 95% confidence interval 0.8–4.7; p = 0.006) smaller normalized whole brain volume. The strongest relationship was seen for the cortical grey matter (beta coefficient 1.6 mL per year; 95% confidence interval 0.5–2.7; p = 0.003), and associations were also found with poorer verbal working memory performance. Body mass index demonstrated the strongest relationships with normalized brain volumes, whilst serum lipid ratios demonstrated strong relationships with verbal and visuospatial working memory performance.Conclusions
Prematurely achieved CVR is associated with lower normalized brain volumes in SPMS. Future longitudinal analyses of this clinical trial dataset will be important to determine whether CVR predicts future disease worsening. 相似文献924.
Annette Maznyczka PhD Sandeep Arunothayaraj MD Mohaned Egred MD Adrian Banning MD Philippe Brunel MD Miroslaw Ferenc MD Thomas Hovasse MD Adrian Wlodarczak PhD Manuel Pan PhD Thomas Schmitz MD Marc Silvestri MD Andrejs Erglis MD Evgeny Kretov PhD Jens Flensted Lassen PhD Alaide Chieffo MD Thierry Lefevre MD Francesco Burzotta MD James Cockburn MD Olivier Darremont MD Goran Stankovic PhD Marie-Claude Morice MD Yves Louvard MD David Hildick-Smith MD EBC MAIN investigators 《Catheterization and cardiovascular interventions》2023,102(3):415-429