全文获取类型
收费全文 | 772篇 |
免费 | 38篇 |
国内免费 | 32篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 15篇 |
妇产科学 | 6篇 |
基础医学 | 113篇 |
口腔科学 | 15篇 |
临床医学 | 66篇 |
内科学 | 145篇 |
皮肤病学 | 15篇 |
神经病学 | 15篇 |
特种医学 | 134篇 |
外科学 | 69篇 |
综合类 | 86篇 |
预防医学 | 30篇 |
眼科学 | 9篇 |
药学 | 70篇 |
肿瘤学 | 53篇 |
出版年
2023年 | 3篇 |
2022年 | 2篇 |
2021年 | 22篇 |
2020年 | 6篇 |
2019年 | 16篇 |
2018年 | 10篇 |
2017年 | 8篇 |
2016年 | 12篇 |
2015年 | 10篇 |
2014年 | 18篇 |
2013年 | 22篇 |
2012年 | 32篇 |
2011年 | 21篇 |
2010年 | 25篇 |
2009年 | 24篇 |
2008年 | 29篇 |
2007年 | 44篇 |
2006年 | 32篇 |
2005年 | 28篇 |
2004年 | 12篇 |
2003年 | 21篇 |
2002年 | 19篇 |
2001年 | 25篇 |
2000年 | 13篇 |
1999年 | 14篇 |
1998年 | 40篇 |
1997年 | 24篇 |
1996年 | 23篇 |
1995年 | 20篇 |
1994年 | 19篇 |
1993年 | 16篇 |
1992年 | 8篇 |
1991年 | 17篇 |
1990年 | 12篇 |
1989年 | 27篇 |
1988年 | 25篇 |
1987年 | 21篇 |
1986年 | 22篇 |
1985年 | 13篇 |
1984年 | 14篇 |
1983年 | 14篇 |
1982年 | 7篇 |
1981年 | 13篇 |
1980年 | 14篇 |
1978年 | 4篇 |
1977年 | 3篇 |
1976年 | 3篇 |
1975年 | 7篇 |
1974年 | 2篇 |
1972年 | 3篇 |
排序方式: 共有842条查询结果,搜索用时 0 毫秒
111.
112.
113.
Training effects on muscle fatigue in man 总被引:1,自引:0,他引:1
Summary Effects of 3 months training, on electrical and mechanical failures during fatigue, were studied in human adductor pollicis muscle. Eight subjects carried out a daily training program of 10 series of 20 fast (0.5 s) voluntary contractions, against a load equivalent to 30–40% of the muscle maximal force. Contractile properties in control and trained muscles are tested by delivering supramaximal electrical pulses (30 Hz) to the motor nerve, thereby triggering series of 60 1-s contractions separated by 1-s intervals. Training produces significant increase in tension development during a 30 Hz isometric tetanus (+13%;P<0.001). Concimitant rates of tension development and of relaxation are respectively augmented by +18% (P<0.001) and +12% (P<0.001). No significant change of surface muscle action potential (SAP) is observed after training. The considerable loss of force recorded during fatigue in control muscles (–36%) is significantly smaller (P<0.001) after training (–17%). Slowing of tension development and of tension relaxation, observed during fatigue in control muscles (respectively –47% and –79%) is smaller after training (respectively –28% and –65%). Analysis of electrical failure indicates that training significantly (P<0.01) reduces augmentation of muscle SAP duration and area recorded during fatigue. Comparison of time courses of mechanical and electrical failures in control and trained muscles, supports the idea that intracellular processes play the major role in tension decay associated with fatigue in human adductor pollicis muscle.This work was supported by the Fonds National de la Recherche Scientifique of Belgium and the Conseil de la Recherche of the University of Brussels 相似文献
114.
Doornbos AM Meynen EM Duchateau GS van der Knaap HC Trautwein EA 《European journal of clinical nutrition》2006,60(3):325-333
OBJECTIVE: To determine the impact of intake occasion (with or without a meal), and product fat level on the cholesterol-lowering efficacy of a plant sterol (PS)-enriched (3 g/day) single-dose yoghurt drink. DESIGN: Double-blind, randomized, placebo-controlled, parallel study with a 4 weeks run-in and 4 weeks intervention period. SETTING: Subjects recruited from the general community. SUBJECTS: A total of 184 moderate hypercholesterolaemic subjects (81 men and 103 women) (age 57+/-2 years) completed the study. INTERVENTIONS: The study product was a 100-g single-dose yoghurt drink with or without added PS in the form of PS esters. The subjects were randomly assigned to one of five 4-week treatments: (i) drink A (0.1% dairy fat, 2.2% total fat) with a meal, (ii) drink A without a meal, (iii) drink B (1.5% dairy fat, 3.3% total fat) with a meal, (iv) drink B without a meal and (v) placebo drink with a meal. RESULTS: LDL-cholesterol (LDL-C) was significantly lowered when the single-dose drink was taken with a meal independent of its fat content (drink A: -9.5% (P<0.001, 95% CI: -13.8 to -5.2); drink B: -9.3% (P<0.001, 95% CI: -13.7 to -4.9)) as compared to placebo. When consumed without a meal, LDL-C was also significantly decreased (drink A: -5.1% (P<0.05, 95% CI: -9.4 to -0.8); drink B: -6.9% (P<0.01, 95% CI: -11.3 to -2.5) as compared to placebo, however the effect was significantly smaller as compared to the intake with a meal. CONCLUSION: These results indicate that a PS-ester-enriched single-dose yoghurt drink effectively reduces LDL-C irrespective of the fat content of the product. A substantially larger decrease in serum cholesterol concentration was achieved when the single-dose drink was consumed with a meal emphasizing the importance of the intake occasion for optimal cholesterol-lowering efficacy. SPONSORSHIP: Unilever Research and Development, Vlaardingen, The Netherlands. 相似文献
115.
116.
Background
Medical Termination of Pregnancy (MTP) is a commonly performed during the first trimester. Dilatation and Evacuation (D & E) mandates rapid dilatation of cervix with metal dilators, which requires anaesthesia and may be associated with trauma to the uterus, cervix and later cervical incompetence. The problem of rapid cervical dilatation is obviated with intravaginal misoprostol.Methods
Intravaginal misoprostol tablet 200 microgram was inserted, a night prior to MTP to ripen the cervix. Cervix was dilated with metal dilators only in cases where cervix did not loosen up sufficiently. Products of conception were removed by suction.Results
Out of 108 cases cervical dilatation was not required in 96 cases (88.9%).Conclusion
Intravaginal misoprostol 200 microgram proved effective as a priming agent prior to MTP in the first trimester.Key Words: Misoprostol, MTP 相似文献117.
T Sinha PP Varma A Srivastava SC Karan AS Sandhu GS Sethi R Khanna R Talwar V Narang 《Medical Journal Armed Forces India》2006,62(3):236-238
Background
Laparoscopic donor nephrectomy (LDN) has been gaining popularity among kidney donors. There have been concerns about the safety and efficacy of the procedure as compared to open donor nephrectomy (ODN). We compare our results on LDN with ODN.Methods
We retrospectively analysed our data of LDN and ODN. Duration of surgery, blood loss, period of hospitalisation, per oral intake and analgesic requirements.Result
22 LDNs were done, the operation time ranged from 220-300 minutes, and blood loss from 100-150ml. In the first 10 laparoscopic operations four cases required conversion to open surgical dissection. Only one case was converted to open surgery in the subsequent 12 laparoscopic cases. Oral intake was started on the first postoperative day. Analgesic requirement in laparoscopy cases was less. Patients were mobilised on the first day after surgery. Patients were discharged by seventh day. There was no significant difference in the functioning of the graft after revascularisation in the recipient.Conclusion
Laparoscopic donor nephrectomy is a safe and effective technique of donor nephrectomy.Key Words: Laparoscopy, Laparoscopic donor nephrectomy, Living kidney donors, Kidney transplantation 相似文献118.
Background
Monoclonal gammopathies occurs in patients with malignant diseases of plasma cells and lymphocytes and in few benign conditions. The objective of this study was to assess the precision, accuracy and confirmation of monoclonal gammopathies on serum protein electrophoresis (SPE) and the clinical relevance of detection and characterization of M component.Methods
All samples received for serum electrophoresis in the last 3 years were analysed for data on M band positivity and correlating it with clinical profile of the patients. Immunofixation (IFE), Immunoelectrophoresis (IEP) and IgG, IgM estimation were carried out in few cases. The follow up of cases was done by serial monitoring of SPE and β2 microglobulin levels.Results
1155 samples were received during the 3 years period. 282 (24.4%) samples were positive for M component on SPE. Of these, 239 (84.8%) patients had M spike in λ region and 43 patients had M spike in β region. The mean load of the M protein band in the λ region was 37.8% and in β region was 35.8%. IgG with κ chain was seen in 40%, IgG with λ chain was seen in 50%, 5% patients each had IgM with κ and IgA with λ light chain. 246 samples (96.5%) had high levels of β2 microglobulin. Of the 116 cases of multiple myeloma, IgG levels was more commonly raised (5%) as compared to IgA (6.9%) and IgM (5.2%).Conclusion
It is recommended that SPE should be performed in patients having unexplained weakness, anaemia, back pain, osteoporosis, osteolytic lesions, fractures, renal insufficiency or recurrent infections.Key Words: Serum protein, Electrophoresis, M band, Multiple myeloma 相似文献119.
120.
A hybrid digital subtraction angiography technique and noise-reduction algorithm were used to evaluate the carotid bifurcation. Temporal, hybrid, and reduced-noise hybrid images were obtained in right and left anterior oblique projections, and both single- and multiple-frame images were created with each method. The resulting images were graded on a scale of 1 to 5 by three experienced neuroradiologists. Temporal images were preferred over hybrid images (average score = 3.2 and 2.4, respectively). The percentage of nondiagnostic examinations, as agreed upon by two readers, was higher for temporal alone than temporal + hybrid (4 and 1, respectively). In addition, also by agreement between two readers, temporal + hybrid images significantly increased the number of bifurcations seen in two views (87%) compared to temporal subtraction alone (64%). 相似文献