钙拮抗剂TMB-8抑制BHQ,NE和KCl引起的培养乳牛基底动脉单个平滑肌细胞内游离钙的升高

用AR CM MIC阳离子测定系统,测量单个细胞内游离钙浓度([Ca²⁺]i),研究8-(N,N-二乙胺)-n-辛基 3,4,5-三甲氧基苯甲酸酯(TMB-8)对培养乳牛基底动脉平滑肌[Ca²⁺]i的作用。在细胞外钙浓度为1.3mmol·L^-1时,TMB-8(30μmol·L^-1)可明显抑制BHQ,NE及KCl引起[Ca²⁺]i的升高。在细胞外钙为零+EGTA 0.1mmol·L^-1时,TMB-8(10,30及100μmol·L^-1)可浓度依赖性地降低静息[Ca²⁺]i,TMB-8(30μmol·L^-1)可几乎完全阻断BHQ及NE引起[Ca²⁺]i的增加。研究表明TMB-8降低培养乳牛基底动脉平滑肌[Ca²⁺]i的机制,主要是抑制肌浆网Ca²⁺的释放,或增加肌浆网对Ca²⁺的摄入,并由此间接地抑制细胞外钙的内流。     

12种中草药的乙醇提取液对印鼠客蚤的毒效研究

目的:探讨中草药灭蚤的可行性。方法:用乙醇提出12种中草药的可溶成分,以瓶膜法测定其对印鼠客蚤的毒力。结果:在0.5g/ml(生药)的浓度下,10种中草药对印鼠客蚤有速效击倒作用,其中鸡血藤、巴豆仁、除虫菊花的10min击倒率大于50％;5种中草药的KD_(50)小于15min,比2％DDVP为优;巴豆仁接触30min恢复24h死亡率为70％。结论:除虫菊花、黎芦、鸡血藤、巴豆仁、贯众用于杀蚤有一定价值。     

Cardiokymograph system with a capacitance transducer and its preliminary application in the measurement of heart wall movement

A novel cardiokymograph system is introduced. The new system features a capacitance transducer with increased sensitivity and can be used in multichannel measurements. The novelty of this technique is the injection of a current into the patient coupled with the use of a capacitive displacement transducer and the possibility of multichannel monitoring. It provides for the possibility of removing breath noise when some signal processing technique, such as adaptive filtering, is used. Further investigation is needed to demonstrate clinical significance and pathologies.     

麦冬类中药组织切片计算机三维重建图鉴

利用计算机技术实现麦冬类中药组织连续切片三维重建与动态显示,为计算机辅助生药学鉴定和教学提供了新的三维图像技术和研究资料。     

A preliminary study of the changes in the direct-acting mutagenicities of several nitropolycyclic aromatic hydrocarbons after exposure under sunlight

Five commercially available nitropolyclyclic aromatic hydrocarbons (nitro-PAH), namely, 4-nitrobiphenyl, 2-nitrofluorene, 9-nitroanthracene, 1-nitropyrene, and 2,7-dinitrofluorene, were exposed under restricted sunlight in the open air. The direct-acting mutagenicities of the samples after an exposure of 45 days were measured in order to compare them with those of the original samples in the Ames Salmonella typhimurium bioassay. It was found that the mutagenicities of some nitro-PAH do not change significantly while the mutagenicities of others increase or decrease after exposure. A preliminary study of nitro-PAH reaction products after exposure using GC, GC/MS, and FT-IR is also reported.     

乙基叔丁醚对动物局部和全身的毒性研究

为了主人乙基叔丁醚（ＥＴＢＥ）的毒性作用，探讨它的灌注溶解治疗胆固醇结石的可能性。我们做了该药物的动物毒性实验，对比ＥＴＢＥ和ＭＴＢＥ（甲基叔丁醚）对动物的局部组织和全身毒性作用。局部毒性实验是对大白兔胆囊进行灌注后，病理观察组织变化。全身毒性实验是通过对小鼠腹腔注射药物的半致死量作对比。结果发现，ＥＴＢＥ对兔的胆囊、胆部属这和十二指肠的损害较ＭＴＢＥ组动物轻。ＥＴＢＥ摇篮腔注射半致死量ＬＤ５０）