全文获取类型
收费全文 | 23143篇 |
免费 | 2481篇 |
国内免费 | 1580篇 |
专业分类
耳鼻咽喉 | 156篇 |
儿科学 | 361篇 |
妇产科学 | 251篇 |
基础医学 | 2921篇 |
口腔科学 | 348篇 |
临床医学 | 3164篇 |
内科学 | 3613篇 |
皮肤病学 | 216篇 |
神经病学 | 1536篇 |
特种医学 | 1003篇 |
外国民族医学 | 20篇 |
外科学 | 2094篇 |
综合类 | 3558篇 |
现状与发展 | 5篇 |
一般理论 | 5篇 |
预防医学 | 1405篇 |
眼科学 | 807篇 |
药学 | 2527篇 |
33篇 | |
中国医学 | 1403篇 |
肿瘤学 | 1778篇 |
出版年
2024年 | 96篇 |
2023年 | 393篇 |
2022年 | 1063篇 |
2021年 | 1312篇 |
2020年 | 981篇 |
2019年 | 857篇 |
2018年 | 903篇 |
2017年 | 734篇 |
2016年 | 731篇 |
2015年 | 1010篇 |
2014年 | 1385篇 |
2013年 | 1124篇 |
2012年 | 1664篇 |
2011年 | 1738篇 |
2010年 | 1070篇 |
2009年 | 907篇 |
2008年 | 1120篇 |
2007年 | 1118篇 |
2006年 | 1176篇 |
2005年 | 1065篇 |
2004年 | 679篇 |
2003年 | 719篇 |
2002年 | 599篇 |
2001年 | 463篇 |
2000年 | 581篇 |
1999年 | 565篇 |
1998年 | 381篇 |
1997年 | 381篇 |
1996年 | 278篇 |
1995年 | 260篇 |
1994年 | 214篇 |
1993年 | 130篇 |
1992年 | 204篇 |
1991年 | 145篇 |
1990年 | 133篇 |
1989年 | 105篇 |
1988年 | 119篇 |
1987年 | 98篇 |
1986年 | 102篇 |
1985年 | 76篇 |
1984年 | 33篇 |
1983年 | 30篇 |
1979年 | 35篇 |
1974年 | 38篇 |
1973年 | 27篇 |
1970年 | 23篇 |
1969年 | 31篇 |
1968年 | 23篇 |
1967年 | 30篇 |
1966年 | 31篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
61.
62.
去带盲升结肠可控膀胱术后远期并发症(附105例报告) 总被引:2,自引:0,他引:2
目的 探讨去带盲升结肠可控膀胱术后远期并发症的发生及防治.方法 回顾性分析1995年10月至2003年1月105例去带盲升结肠可控膀胱术后患者资料.男83例,女22例.年龄32~78岁,平均60岁.随访时间9~82个月,平均40.5个月.结果 发生远期并发症27例(25.7%),其中导尿插管困难4例(3.8%),3例行尿道扩张后治愈,1例再次手术利用末段回肠重建输出道;贮尿囊结石5例(4.8%),4例行贮尿囊切开取石治愈,1例无自觉症状者未行处理;贮尿囊穿孔1例(0.9%),行手术修补后痊愈;贮尿囊过度扩张1例(0.9%),行贮尿囊缩小术;肾积水8例(7.6%),合并输尿管返流1例,合并下段输尿管狭窄4例,其中2例行狭窄段输尿管切除再吻合,1例术前为氮质血症者发展为尿毒症需行规律血透;血氯增高7例(6.7%),1例出现高氯性酸中毒需长期口服碳酸氢钠;单纯表现为症状性泌尿系感染1例(0.9%).27例中另合并症状性泌尿系感染10例,根据尿培养结果予敏感抗生素治愈.结论 去带盲升结肠可控膀胱术后远期并发症多与症状性泌尿系感染相关,积极防治泌尿系感染,规律、充分的贮尿囊冲洗及定时清洁导尿对远期并发症的预防有重要作用. 相似文献
63.
急性心肌梗死患者出现束支传导阻滞(BBB)被认为与预后差有关。这种观点在血管成形术时代是否正确尚不清楚。本研究旨在评估采用直接血管成形术治疗的急性心肌梗死伴BBB患者的预后。评估了急性心肌梗死直接血管成形术试验中3053例接受急诊导管术的患者。将入院心电图存在左束支传导阻滞的患者(LBBB,n=48,1.6%)与右束支传导阻滞患者(RBBB,n=95,3.1%)或无BBB患者(n=2910,95.3%)进行比较。具有BBB的患者年龄较大,更多见糖尿病、外周血管疾病和曾行冠状动脉搭桥术,射血分数较低,多支血管病变多见。 相似文献
64.
Q开关Nd:YAG激光不同波长治疗面部毛细血管扩张疗效比较 总被引:5,自引:0,他引:5
目的:观察Q开关Nd:YAG激光不同波长治疗面部毛细血管扩张的疗效及副反应。方法:128例病人按治疗波长随机分为532nm组75例,585nm组53例,治疗光斑2.0mm,能量密度2.2-6.8J/cm。,脉宽10ns;术后3个月根据术前照片判定疗效,标准分为Ⅳ级。结果:治疗次数1-4次,间隔时间3-5个月,两组共治愈71例(55,47%),疗效与治疗次数成正相关。其中532nm组治愈36例(48.00%),平均治愈次数2.64次;585nm组治愈35例(66.04%,),平均治愈次数2.40次,两组痊愈率及副反应差异无显性。结论:Q开关Nd:YAG激光倍频532/nm和585nm两种波长对密度较低、直径较细的面部毛细血管扩张均有可靠疗效,术后除色素沉着发生较高外,其他不良反应较少。 相似文献
65.
目的:观察重症急性胰腺炎(SAP)大鼠白血病抑制因子(LIF)在肺组织中表达的时相变化, 探讨LIF在SAP病程及肺损伤中的意义.方法:36只♂SD大鼠随机分为正常对照组(N 组,n=6)、假手术组(Sham组,n=6)和重症急性胰腺炎组(SAP组,n=24).采用胰管逆行灌注50 g/L牛磺胆酸钠的方法复制大鼠SAP模型.用RT-PCR法检测肺组织中LIF mRNA的表达水平,免疫组织化学方法检测NLIF在肺组织中的表达变化.结果:SAP组3 h后肺组织LIF mRNA的表达量明显高于对照组和假手术组(灰度值:1.018± 0.065 vs 1.451±0.067,1.322±0.072,P<0,05), 并且6,12,24 h持续升高(0.853±0.058,0.635 ±0.064,0.582±0.089)(P<0.01).同样,SAP组 LIF蛋白表达在3和6 h后明显高于对照组和假手术(127.36±2.76,122.53±2.43 vs 159.46 ±2.78,156.35±3.12,P<0.05),并且12,24 h后也维持在很高的水平(109.37±2.87,102.42± 2.27).结论:LIF作为促炎症因子参与了SAP肺组织的炎症反应. 相似文献
66.
Zheng Qi-xin Zhu Tong-bai Du Jing-yuan Hong Guang-xiang Li Shi-pu Yan Yun-hua Zhang En-dang 《华中科技大学学报(医学英德文版)》1992,12(3):173-178
Summary The authors have prepared the artificial bone of porous tricalcium phosphate ceramics according to an appropriate formula
and manufacturing technology. Physical and chemical testing shows that it possesses several distinguishing features: the communicating
pores and macro/micropores; mean pore size, 380 μm (from 240 μm to 510 μm); porosity, 46.4 %; and compressive strength, 97.4
kg/cm2. It consists of CaO (49.09 %) and P2O5 (48.84 %). The testing of its biocompatibility shows that it is devoid of systemic or local toxicity, and free of irritation
or foreign body response in tissues, and it does not result in hemolysis or mutation. The new bone readily grows into its
pores with direct contact to the implanted material. 11 cases of bone defects were treated with this artificial bone with
satisfactory results. 相似文献
67.
The subdivisions of the sacral intermediolateral nucleus (IML) of the cat have been studied by using a double-labeling technique of retrograde Fluoro-gold (FG) and wheat germ agglutinin-conjugated horseradish peroxidase (WGA-HRP) tracing. The parasympathetic preganglionic neurons (PGNs) that were labeled by the FG injected into the pelvic nerve formed a ‘V’-shaped column known as the sacral parasympathetic nucleus (SPN) in the sacral IML. The neurons that were labeled by the WGA-HRP applied to the lateral parabrachial nucleus (PBL) formed an elongated spindle-shaped column extending throughout the IML of the sacral segments. We designated it by the name of sacral visceral sensory nucleus (SVSN). These findings indicate that the sacral IML of the cat contain two distinct subdivisions, SPN and SVSN. 相似文献
68.
J. Pfisterer F. Kommoss W. Sauerbrei B. Baranski M. Kiechle H. Ikenberg A. Du Bois & A. Pfleiderer 《International journal of gynecological cancer》1996,6(1):54-60
In a retrospective study the prognostic significance of nuclear DNA content was investigated, as measured by flow cytometry, of the tumor specimens from 212 women with nonpretreated FIGO stage IB and II cervical cancer. One-hundred and thirty cases (62%) were found to be diploid, whereas 82 (38%) were aneuploid. Univariate analysis of the follow-up data showed an increased relative risk (RR) for recurrence free survival (RFS) for stage II tumors (RR = 1.87, 95% CI: 1.13–3.10, P = 0.015) and for age (RR = 1.52, 95% CI: 0.66–3.52 and RR = 2.35, 95% CI: 1.19–4.65, P = 0.032). Ploidy showed a relative risk of 1.33 (95% CI: 0.83–2.13, NS). In addition, univariate analysis of overall survival (OS) revealed similar results. For the subgroup of patients with primary surgery ( n = 151), positive pelvic nodes (RR = 5.38, 95% CI: 2.70–10.71, P = 0.0001) and parametrial extension (RR = 2.53, 95% CI: 1.24–5.17, P = 0.011) were significant factors for OS after univariate analysis, the estimated effects on RFS were slightly smaller. Multivariate analysis of RFS for the whole study population showed age, histologic grade and stage with a slightly increased risk, but no effect was significant. Ploidy with an RR of 0.97 (95% CI: 0.58–1.62) seems to have no influence on prognosis. For the subgroup with primary surgery, ploidy again failed statistical significance with an RR of 1.20 (95% CI: 0.58–2.49). Our results suggest that abnormalities of the nuclear DNA content in this homogeneous group of patients are associated with clinical and morphological prognosticators, however, ploidy is not an independent prognostic factor for RFS, or for the whole study population or for the subgroup with primary surgery. 相似文献
69.
中西医结合治疗坏死性筋膜炎 总被引:1,自引:0,他引:1
本文积累了1981~1994年近十余年的临床资料,总结了中西医结合治疗坏死性筋膜炎的临床治疗经验。指出坏死性筋膜炎是一种少见的严重的软组织感染,发展迅速,病死率高,应引起临床医生的高度警惕,做出早期诊断是非常必要的。提出了扶正祛邪的中西医结合的整体治疗方案,全身治疗与局部处理相结合。对患处要采取早期,这时的多切口引流,给"邪"以出路。取得良好的疗效。 相似文献
70.
Effect of isoelectric point on biodistribution and inflammation imaging with indium-111-labelled IgG
Caroline I. ten Kate Alan J. Fischman Robert H. Rubin A. J. Fucello D. Riexinger Robert A. Wilkinson Lina Du Ban An Khaw H. William Strauss 《European journal of nuclear medicine and molecular imaging》1990,17(6-8):305-309
Electrostatic effects play an important role in protein interactions and may alter the biodistribution of antibodies. To study the effect of molecular charge on the biodistribution and infection imaging properties of human polyclonal immunoglobulin G (IgG), its iso electric point was varied by changing the level of diethylene triamine penta-acetic acid (DTPA) substitution: 0.8, 0.9, 3.7, 5.1 and 5.9 DTPA/IgG. Biodistributions of the different IgG preparations were determined at 10 min, 1, 6, 24, and 48 h post injection in normal rats, and infection imaging properties were determined in rats withEscherichia coli thigh infections. The biodistribution was significantly affected by pl. The immunoglobulin preparations with 0.9 and 3.7 DTPA/IgG showed faster clearance from the circulation and generally lower accumulation in most organs. The images had a target-to-background ratio of approximately 1.3–2.3:1. These results suggest that even though targeting is not affected by the level of DTPA substitutions, preparations with 0.9 and 3.7 DTPA/IgG may be superior imaging agents because of reduced accumulation by background organs. 相似文献