全文获取类型
收费全文 | 2267篇 |
免费 | 89篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 39篇 |
儿科学 | 103篇 |
妇产科学 | 138篇 |
基础医学 | 285篇 |
口腔科学 | 39篇 |
临床医学 | 139篇 |
内科学 | 442篇 |
皮肤病学 | 58篇 |
神经病学 | 199篇 |
特种医学 | 49篇 |
外科学 | 116篇 |
综合类 | 14篇 |
一般理论 | 1篇 |
预防医学 | 232篇 |
眼科学 | 115篇 |
药学 | 254篇 |
中国医学 | 2篇 |
肿瘤学 | 146篇 |
出版年
2024年 | 2篇 |
2023年 | 18篇 |
2022年 | 87篇 |
2021年 | 117篇 |
2020年 | 37篇 |
2019年 | 55篇 |
2018年 | 65篇 |
2017年 | 50篇 |
2016年 | 57篇 |
2015年 | 75篇 |
2014年 | 96篇 |
2013年 | 106篇 |
2012年 | 206篇 |
2011年 | 203篇 |
2010年 | 105篇 |
2009年 | 88篇 |
2008年 | 138篇 |
2007年 | 123篇 |
2006年 | 153篇 |
2005年 | 148篇 |
2004年 | 146篇 |
2003年 | 119篇 |
2002年 | 112篇 |
2001年 | 7篇 |
2000年 | 3篇 |
1999年 | 11篇 |
1998年 | 9篇 |
1997年 | 6篇 |
1996年 | 3篇 |
1995年 | 4篇 |
1994年 | 7篇 |
1993年 | 2篇 |
1992年 | 1篇 |
1991年 | 2篇 |
1989年 | 2篇 |
1988年 | 1篇 |
1986年 | 1篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1982年 | 1篇 |
1980年 | 1篇 |
1977年 | 1篇 |
1966年 | 1篇 |
排序方式: 共有2371条查询结果,搜索用时 31 毫秒
91.
92.
Misztal T Górski K Tomaszewska-Zaremba D Molik E Romanowicz K 《The Journal of endocrinology》2008,198(1):83-89
The push-pull perfusions of the infundibular nucleus-median eminence (IN/ME) were made in lactating ewes (n=7) twice, to identify dopamine (DA)-derived salsolinol and the changes in its extracellular concentration in response to suckling. The perfusate collecting period in every ewe consisted of control non-suckling period, 1000-1230 h (five perfusates), and suckling period, 1230-1500 h (next five perfusates). Simultaneously, blood samples were collected from 1000 to 1500 h at 10-min intervals. The perfusate concentrations of salsolinol and DA were measured by HPLC, and plasma prolactin and GH concentrations were assayed by the RIA. Mean concentrations of salsolinol in perfusates collected from the anterior and posterior parts of the IN/ME (according to post-mortem localization of a perfusion site) increased significantly (P<0.05 and P<0.001 respectively) during the suckling period, when compared with those noted during the non-suckling period. While no DA was found in the anterior part, only vestigial amounts of DA were found in a few perfusates collected from the posterior part. Salsolinol was not detected in the IN/ME of ewes 10 weeks after weaning (seasonal anoestrus). Mean plasma prolactin and GH concentrations during suckling were significantly (P<0.001) higher than those noted during the non-suckling period. In conclusion, our current study reveals that salsolinol is present in the IN/ME of lactating ewes and that its extracellular concentration increases during suckling. Moreover, it supports the role of salsolinol as a neurotransmitter involved in the regulatory process of prolactin secretion at least during lactation. 相似文献
93.
Marta Kieć-Świerczyńska Dominika Świerczyńska-Machura Dorota Chomiczewska-Skóra Ewa Nowakowska-Świrta Beata Kręcisz 《International journal of occupational medicine and environmental health》2014,27(2):196-205
Objectives
To evaluate sensitization to chemicals present in work environment after an outbreak of contact dermatitis in workers of vehicle equipment factory, exposed to polyurethane foam, based on 4,4′-diphenylmethane diisocyanate (MDI).Material and Methods
From among 300 employees, 21 individuals reporting work-related skin and/or respiratory tract symptoms underwent clinical examination, patch testing, skin prick tests, spirometry and MDI sIgE measurement in serum. Patch tests included isocyanates series, selected rubber additives, metals, fragrances, preservatives, and an antiadhesive agent.Results
Clinical examination revealed current eczema in the area of hands and/or forearms in 10 workers. Positive patch test reactions were found in 10 individuals, the most frequent to diaminodiphenylmethane and 4-phenylenediamine (7 persons). Reactions to an antiadhesive agent were assessed as irritant (5 workers). Except for sensitization to common aeroallergens, no significant abnormalities were found in the remaining tests. Occupational allergic contact dermatitis was diagnosed in 7 workers, irritant contact dermatitis in 10 and coexisiting allergic and irritant contact dermatitis in 3 workers.Conclusions
In workers manufacturing products from polyurethane foam, attention should be paid to the risk of developing contact dermatitis. Skin problems in our study group were attributable probably to insufficient protection of the skin. 相似文献94.
The article presents a systematic review protocol. The aim of the study is an assessment of current studies regarding the application of artificial intelligence and neural networks in the screening for adverse perinatal outcomes. We intend to compare the reported efficacy of these methods to improve pregnancy care and outcomes. There are more and more studies that describe the role of machine learning in facilitating the diagnosis of adverse perinatal outcomes, like gestational diabetes or pregnancy hypertension. A systematic review of available literature seems to be crucial to compare the known efficacy and application. Publication of a systematic review in this category would improve the value of future studies. The studies reporting on artificial intelligence application will have a major impact on future prenatal practice. 相似文献
95.
Rheumatology International - New markers of systemic lupus erythematosus (SLE) activity are under investigation. In recent years, the researchers have been focusing increased attention on the role... 相似文献
96.
Mari Aikio Harri Elamaa David Vicente Valerio Izzi Inderjeet Kaur Lotta Seppinen Helen E. Speedy Dorota Kaminska Sanna Kuusisto Raija Sormunen Ritva Heljasvaara Emma L. Jones Mikko Muilu Matti Jauhiainen Jussi Pihlajam?ki Markku J. Savolainen Carol C. Shoulders Taina Pihlajaniemi 《Proceedings of the National Academy of Sciences of the United States of America》2014,111(30):E3043-E3052
97.
98.
Sonja Zweegman Claudia A.M. Stege Einar Haukas Fredrik H. Schjesvold Mark-David Levin Anders Waage Rineke B.L. Leys Saskia K. Klein Damian Szatkowski Per Axelsson Trung Hieu Do Dorota Knut-Bojanowska Ellen van der Spek Asta Svirskaite Anja Klostergaard Morten Salomo Celine Blimark Paula F. Ypma Ulf-Hendrik Mellqvist Pino J. Poddighe Marian Stevens-Kroef Niels W.C.J. van de Donk Pieter Sonneveld Markus Hansson Bronno van der Holt Niels Abildgaard 《Haematologica》2020,105(12):2879
99.
Pawel Robak Dorota Jesionek-Kupnicka Piotr Kupnicki Aaron Polliack Tadeusz Robak 《European journal of haematology》2020,105(6):682-691
Skeletal involvement is a rare complication of hairy cell leukemia (HCL) with an incidence of approximately 3%. Bone lesions are commonly lytic, and the most common sites of involvement are the femoral head and neck. Skeletal involvement is typically associated with high tumor burden and bone marrow infiltration. However, isolated cases of skeletal disease without splenomegaly or bone marrow involvement are occasionally reported. This review focuses on skeletal lesions in HCL, particularly the pathogenesis, clinical symptoms, diagnostic methods, and treatment approach. A literature review of the MEDLINE database for articles in English concerning hairy cell leukemia, skeletal symptoms, bone involvement was conducted via PubMed. Publications from January 1970 to May 2020 were scrutinized. Additional relevant publications were obtained by reviewing the references from the chosen articles. 相似文献
100.
Mirosław Banasik Maria Boratyńska Katarzyna Kościelska‐Kasprzak Dorota Kamińska Dorota Bartoszek Marcelina Żabińska Marta Myszka Sławomir Zmonarski Marcin Protasiewicz Beata Nowakowska Agnieszka Hałoń Pawel Chudoba Marian Klinger 《Transplant international》2014,27(10):1029-1038
Non‐HLA antibodies (Abs) targeting vascular receptors are thought to have an impact on renal transplant injury. Anti‐angiotensin II type 1‐receptor‐activating antibodies (anti‐AT1R) have been mentioned to stimulate a severe vascular rejection, but the pretransplant screening has not been introduced yet. The aim of our study was to assess the incidence and importance of anti‐AT1R antibodies and their influence on renal transplant in the 1st year of observation. We prospectively evaluated the presence of anti‐AT1R antibodies in 117 consecutive renal transplant recipients in pre‐ and post‐transplant screening. Anti‐AT1R antibodies were observed in 27/117 (23%) of the analyzed recipients already before transplantation. The function of renal transplant was considerably worse in anti‐AT1R(+) group. The patients with anti‐AT1R Abs >9 U/ml lost their graft more often. Biopsy‐proven AR was described in 4/27 (15%) pts in the anti‐AT1R(+) group and 13/90 (14.4%) in the anti‐AT1R(?) group, but more severe cases of Banff IIB or antibody‐mediated rejection (AMR) were more often observed in anti‐AT1R (+) 4/27 (15%) vs. 1/90 (1.1%) in anti‐AT1R(+) (P = 0.009). Patients with anti‐AT1R Abs level >9 U/ml run a higher risk of graft failure independently of classical immunological risk factors. The recipients with anti‐AT1R Abs developed more severe acute rejections described as IIB or AMR in Banff classification. More recipients among the anti‐AT1R‐positive ones lost the graft. Our study suggests monitoring of anti‐AT1R Abs before renal transplantation for assessment of immunologic risk profiles and the identification of patients highly susceptible to immunologic events, graft failure, and graft loss. 相似文献