全文获取类型
收费全文 | 71990篇 |
免费 | 6005篇 |
国内免费 | 3710篇 |
专业分类
耳鼻咽喉 | 804篇 |
儿科学 | 899篇 |
妇产科学 | 714篇 |
基础医学 | 9159篇 |
口腔科学 | 1051篇 |
临床医学 | 8136篇 |
内科学 | 12170篇 |
皮肤病学 | 1271篇 |
神经病学 | 4195篇 |
特种医学 | 3695篇 |
外国民族医学 | 19篇 |
外科学 | 7752篇 |
综合类 | 8942篇 |
现状与发展 | 14篇 |
一般理论 | 8篇 |
预防医学 | 4142篇 |
眼科学 | 1722篇 |
药学 | 7667篇 |
51篇 | |
中国医学 | 3090篇 |
肿瘤学 | 6204篇 |
出版年
2024年 | 173篇 |
2023年 | 893篇 |
2022年 | 2391篇 |
2021年 | 3263篇 |
2020年 | 2315篇 |
2019年 | 2210篇 |
2018年 | 2330篇 |
2017年 | 2136篇 |
2016年 | 2456篇 |
2015年 | 3517篇 |
2014年 | 4179篇 |
2013年 | 4232篇 |
2012年 | 6102篇 |
2011年 | 6249篇 |
2010年 | 4458篇 |
2009年 | 3376篇 |
2008年 | 4220篇 |
2007年 | 4123篇 |
2006年 | 3658篇 |
2005年 | 3550篇 |
2004年 | 2634篇 |
2003年 | 2603篇 |
2002年 | 2194篇 |
2001年 | 1514篇 |
2000年 | 1202篇 |
1999年 | 1101篇 |
1998年 | 659篇 |
1997年 | 623篇 |
1996年 | 425篇 |
1995年 | 476篇 |
1994年 | 342篇 |
1993年 | 213篇 |
1992年 | 318篇 |
1991年 | 248篇 |
1990年 | 205篇 |
1989年 | 215篇 |
1988年 | 152篇 |
1987年 | 157篇 |
1986年 | 145篇 |
1985年 | 95篇 |
1984年 | 58篇 |
1983年 | 38篇 |
1982年 | 31篇 |
1981年 | 26篇 |
1980年 | 23篇 |
1979年 | 27篇 |
1974年 | 15篇 |
1973年 | 21篇 |
1971年 | 14篇 |
1969年 | 20篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
41.
Dong Hwee Kim Yoon Kyoo Kang Miriam Hwang Ho Sung Jo Ki Hoon Kim 《Clinical neurophysiology》2004,115(5):1021-1026
OBJECTIVE: To evaluate the usefulness of the TenElectrodes, a new stimulator for inching test, in the diagnosis and localization of ulnar neuropathy at the elbow (UNE). METHODS: Sixty-two ulnar nerves in 40 control subjects and 24 ulnar nerves in 23 patients with typical symptoms and signs of UNE were studied. The inching test of ulnar motor nerve using TenElectrodes was done along 8 cm across the elbow in the extended position. RESULTS: In the inching test of the control group, the mean segmental latency difference was 0.19+/-0.08 ms. Maximal latency difference over a 1 cm segment did not exceed 0.40 ms in any of the controls but exceeded 0.5 ms or more in all clinical UNE patients. In all UNE patients, the lesion sites were identified by the inching test using TenElectrodes: the retroepicondylar groove (54.2%), the humeroulnar arcade (29.2%), and dual compression (16.6%). CONCLUSIONS: TenElectrodes is a useful stimulator for the inching test in the diagnosis of UNE. The precise localization of compression was possible in all patients with UNE and the most common site was the retroepicondylar groove. 相似文献
42.
[目的 ]探讨细针穿刺乳腺肿瘤组织的端粒酶活性检测在乳腺癌诊断中的意义 .[方法 ]用聚合酶链反应 酶联免疫吸附测定法检测 79例术前乳腺肿瘤细针穿刺活检标本和大体标本的端粒酶活性 ,并与病理诊断进行比较 .[结果 ]乳腺癌 6 5例中穿刺组织端粒酶呈阳性的为 5 7例 ,阳性率为 88% ;大体组织端粒酶呈阳性的为 5 4例 ,阳性率为 83% .淋巴结转移者端粒酶活性高于无淋巴结转移者 .乳腺良性疾病 14例中端粒酶呈阳性的为 2例 ,阳性率为 14 % .[结论 ]术前乳腺肿瘤穿刺组织的端粒酶活性检测有利于乳腺肿瘤的早期诊断及鉴别诊断 . 相似文献
43.
目的 评价开放复位可塑形钛板内固定治疗跟骨骨折的疗效。方法 对33例(37足)以后关节突移位为主的跟骨骨折,行跟骨外侧入路、开放性复位可塑形钛板螺钉内固定,必要时行植骨术(18例)。结果 平均随访11.5个月,参照Mary—land food score评分,对患足是否疼痛、步态、距下关节及踝关节活动度、是否支架辅助、术后X线摄片等加以评估,19足疗效为优,17足为良,1足可。其中钛板断裂1例,手术切口皮缘坏死1例,换药后自愈。结论 跟骨外侧入路开放复位可塑形钛板螺钉内固定,必要时植骨术是治疗跟骨骨折的有效方法。 相似文献
44.
45.
Eun Hee Sohn Chang Joon Song Hyo-Jin Lee Samyong Kim Jae-Moon Kim Ae Young Lee 《JOURNAL OF CLINICAL NEUROLOGY》2007,3(2):108-111
Lymphomatoid granulomatosis (LG) is a potentially malignant lymphoproliferative disorder. The lung is the most common involved site, followed by the skin and nervous system. However, LG of the central nervous system presenting with Parkinsonism is very rare. We report a patient with LG who presented with parkinsonian features such as bilateral rigidity, bradykinesia, and agitation. Brain magnetic resonance imaging showed multifocal punctuate enhanced lesions in both supra- and infratentorial areas. Steroid pulse therapy resulted in a dramatical improvement in the symptoms and MRI abnormalities. 相似文献
46.
电脑比配色仪与比色板之间的相近性分析 总被引:1,自引:0,他引:1
目的:通过对比色记录的分析,比较Vita比色板、松风Vintage Halo比色板和电脑比配色仪之间的相近性和差异性。方法:随机抽取100名年龄在21~24岁的本地在校大学生,由男女两位测试者使用电脑比配色仪、Vita比色板和松风Vintage Halo比色板对被测试者的左上中切牙进行比色分析。结果:三种比色方法均以A色调最为集中,占总数的55%以上。其次是D色调占总数20%以上。男女测试者的选色在A、R、VR.系列中无明显差异。结论:电脑比配色仪、Vita比色板、松风Vintage Halo比色板均不能完全覆盖本地区青年天然中切牙的色度特征,只在A色调系列中重复率较高。 相似文献
47.
凹槽交锁髓内钉治疗股骨多段骨折(附18例报告) 总被引:4,自引:1,他引:3
目的探讨一种新型交锁髓内钉-凹槽交锁股骨髓内钉(Biorigid nail femur,简称BNF)治疗股骨多段骨折的方法。方法自2002年3月~2003年10月应用德国aap公司生产的BNF治疗骨折多段骨折18例。结果本组经过3~18个月、平均9个月的随访。骨折均愈合,膝、髋关节恢复良好。结论BNF具有设计独特、内固定可靠、主钉全程均可交锁的特点,能满足自股骨转子下到股骨髁之间一处或多处骨折内固定需要。 相似文献
48.
49.
Su Jin Park Su Jin Kim Yumie Rhee Ji Hyun Byun Seong Hwan Kim Myoung Hee Kim Eun Jig Lee Sung-Kil Lim 《Journal of bone and mineral research》2007,22(6):889-896
The FIGNL1 gene was proven to be a new subfamily member of ATPases associated with diverse cellular activities (AAA proteins). In this in vitro study, the AAA proteins inhibited osteoblast proliferation and stimulated osteoblast differentiation. We showed that FIGNL1 may play some regulatory role in osteoblastogenesis. INTRODUCTION: The fidgetin-like 1 (FIGNL1) gene encodes a new subfamily member of ATPases associated with diverse cellular activities (AAA proteins). Although the FIGNL1 protein localizes to both the nucleus and cytoplasm, the function of FIGNL1 remains unknown. In a previous study, we identified several genes that mediate the anabolic effects of basic fibroblast growth factor (bFGF) on bone by using microarray data. FIGNL1 was one of the genes that downregulated >2-fold in MC3T3-E1 cells after treatment with bFGF. Therefore, this study was aimed to identify and confirm the function of FIGNL1 on osteoblastogenesis. MATERIALS AND METHODS: We examined the effect of the FIGNL1 gene on proliferation, differentiation, and apoptosis in mouse osteoblast cells (MC3T3-E1 and mouse primary calvarial cells) using flow cytometry, RT-PCR, cell proliferation assay, and cell death assay. MC3T3-E1 cells and mouse calvarial cells were transfected with small interfering RNA (siRNA) directed against the FIGNL1 or nontargeting control siRNA and examined by cell proliferation and cell death assays. Also, FIGNL1 was fused to enhance green fluorescent protein (EGFP), and the EGFP-fused protein was transiently expressed in MC3T3-E1 cells. RESULTS: Reduced expression of FIGNL1 by bFGF and TGF-beta1 treatment was verified by RT-PCR analysis. Overexpression of FIGNL1 reduced the proliferation of MC3T3-E1 and calvarial cells, more than the mock transfected control cells did. In contrast, siFIGNL1 transfection significantly increased the proliferation of osteoblasts, whereas overexpression of FIGNL1 did not seem to alter apoptosis in osteoblasts. Meanwhile, overexpression of FIGNL1 enhanced the mRNA expression of alkaline phosphatase (ALP) and osteocalcin (OCN) in osteoblasts. In contrast, siFIGNL1 decreased the expression of ALP and OCN. A pEGFP-FIGNL1 transfected into MCT3-E1 cells had an initially ubiquitous distribution and rapidly translocated to the nucleus 1 h after bFGF treatment. CONCLUSIONS: From these results, we proposed that FIGNL1, a subfamily member of the AAA family of proteins, might play some regulatory role in osteoblast proliferation and differentiation. Further analyses of FIGNL1 will be needed to better delineate the mechanisms contributing to the inhibition of proliferation and stimulation of osteoblast differentiation. 相似文献