全文获取类型
收费全文 | 2177篇 |
免费 | 114篇 |
国内免费 | 19篇 |
专业分类
耳鼻咽喉 | 54篇 |
儿科学 | 71篇 |
妇产科学 | 122篇 |
基础医学 | 182篇 |
口腔科学 | 105篇 |
临床医学 | 185篇 |
内科学 | 507篇 |
皮肤病学 | 62篇 |
神经病学 | 120篇 |
特种医学 | 83篇 |
外科学 | 478篇 |
综合类 | 30篇 |
预防医学 | 44篇 |
眼科学 | 56篇 |
药学 | 73篇 |
中国医学 | 3篇 |
肿瘤学 | 135篇 |
出版年
2023年 | 16篇 |
2022年 | 22篇 |
2021年 | 34篇 |
2020年 | 33篇 |
2019年 | 53篇 |
2018年 | 54篇 |
2017年 | 51篇 |
2016年 | 75篇 |
2015年 | 81篇 |
2014年 | 105篇 |
2013年 | 128篇 |
2012年 | 171篇 |
2011年 | 173篇 |
2010年 | 96篇 |
2009年 | 94篇 |
2008年 | 144篇 |
2007年 | 200篇 |
2006年 | 158篇 |
2005年 | 160篇 |
2004年 | 113篇 |
2003年 | 85篇 |
2002年 | 72篇 |
2001年 | 40篇 |
2000年 | 44篇 |
1999年 | 28篇 |
1998年 | 5篇 |
1997年 | 10篇 |
1996年 | 10篇 |
1995年 | 3篇 |
1993年 | 2篇 |
1992年 | 3篇 |
1991年 | 4篇 |
1990年 | 3篇 |
1989年 | 4篇 |
1988年 | 2篇 |
1980年 | 1篇 |
1978年 | 2篇 |
1977年 | 2篇 |
1974年 | 1篇 |
1973年 | 4篇 |
1972年 | 5篇 |
1971年 | 1篇 |
1970年 | 5篇 |
1969年 | 1篇 |
1968年 | 1篇 |
1967年 | 3篇 |
1966年 | 1篇 |
1965年 | 1篇 |
1963年 | 1篇 |
1960年 | 1篇 |
排序方式: 共有2310条查询结果,搜索用时 93 毫秒
31.
32.
OBJECTIVES: We have described our experience with transcatheter occlusion of congenital coronary arterial fistulas in adults. METHODS: Six symptomatic patients, mean aged 41+/-12 years (four men, two women) underwent transcatheter occlusion of fistulas. All had chest pain or dyspnea on exertion. Four of the patients had single fistula. Two of the patients had multiple fistulas. The fistulas originated from the left anterior descending coronary artery in four patients, and from the circumflex artery in two. They all drained into the pulmonary trunk. Graft stenting was used in two patients who had multiple fistulas, and coils in four who had a single fistula. The coils were implanted through a microcatheter, which was passed through a JL 4 8F guiding catheter. RESULTS: Coils were used to completely occlude fistulas. Two 3.0x20 mm coronary graft stents were deployed in the coronary arteries to occlude the fistulas. The procedures were uncomplicated. At follow up, all patients underwent coronary angiography, and one of the patients with coil embolization and one of the patients with graft stenting had small residual flow. Patient's chest pain or dyspneas have resolved after the procedure. CONCLUSION: Transcatheter closure in adults of congenital coronary fistulas with graft stents and coils are safe and effective, and can be regarded as an acceptable alternative to surgery. 相似文献
33.
Fadlullah Aksoy Remzi Dogan Orhan Ozturan Selahattin Tugrul Bayram Veyseller Omer Faruk Ozer Alev Pektas 《Clinical and experimental otorhinolaryngology》2015,8(4):312-319
Objectives
In this study we investigated the probable protective effects of thymoquinone on amikacin-induced ototoxicity in rats.Methods
Thirty-two healthy rats were divided into four groups (amikacin, amikacin+thymoquinone, thymoquinone, and no treatment). Thymoquinone was fed to the rats via oral gavage in a dose of 40 mg/kg/day throughout the study period of 14 days. Amikacin was given by the intramuscular route in a dose of 600 mg/kg/day. Audiological assessment was conducted by the distortion product otoacoustic emission (DPOAE) and auditory brainstem response (ABR) tests, administered to all rats at the beginning of the study, and also on days 7 and 15. Biochemical parameters were calculated at the termination of the study to evaluate the oxidative status.Results
There were significant decreases in DPOAE values and significant increases in ABR thresholds of the amikacin group on days 7 and 15, as compared to the amikacin+thymoquinone group. While ABR thresholds of the amikacin group increased significantly on days 7 and 15 as compared to their initial values, there were no significant differences between the initial and the 7th and 15th day values of ABR thresholds in the amikacin+thymoquinone group. Total oxidant status and oxidative stress index values of the amikacin+thymoquinone group were significantly lower than those of the amikacin group. Total antioxidant status values of the amikacin+thymoquinone group were significantly higher than those of the amikacin group.Conclusion
Our study has demonstrated that the ototoxic effect brought forth by amikacin could be overcome with the concurrent use of thymoquinone. 相似文献34.
Consistent copy number changes and recurrent PRKAR1A mutations distinguish Melanotic Schwannomas from Melanomas: SNP‐array and next generation sequencing analysis
下载免费PDF全文
![点击此处可从《Genes, chromosomes & cancer》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Lu Wang Ahmet Zehir Justyna Sadowska Nengyi Zhou Marc Rosenblum Klaus Busam Narasimhan Agaram William Travis Maria Arcila Snjezana Dogan Michael F. Berger Donavan T. Cheng Marc Ladanyi Khedoudja Nafa Meera Hameed 《Genes, chromosomes & cancer》2015,54(8):463-471
Melanotic Schwannomas (MS) are rare tumors that share histological features with melanocytic tumors and schwannomas. However, their genetics are poorly understood. To elucidate the genetic characteristics of MS, we performed genome‐wide studies in a series of cases. Twelve MS cases were available for the study. Genomic DNAs extracted from formalin‐fixed paraffin embedded tumor tissues were subjected to copy number (CN) and allelic imbalance (AI) analysis by Single Nucleotide Polymorphism (SNP)‐array and screened for mutations in coding exons of 341 key cancer‐associated genes using a hybrid capture‐based next‐generation sequencing (NGS) assay. Sanger sequencing was used to further verify recurrent mutations detected by NGS study. SNP‐array analysis revealed remarkably stereotypic chromosomal abnormalities in MS. Hypodiploidy was common, typically involving monosomies of chromosomes 1, 2, and 17. All 12 samples showed mutations in PRKAR1A gene, including 2 cases with 2 mutations each. The 14 mutations were scattered across PRKAR1A, and most were inactivating mutations. AI on 17q, presenting as loss of heterozygosity with or without CN losses, combined with a PRKAR1A mutation was observed in 9/12 MS cases. The remaining 3 cases included the two samples harboring two mutations in PRKAR1A. MS exhibits a stereotypic pattern of chromosomal losses. In contrast, melanomas are typically characterized by the presence of multiple CN aberrations, without demonstrable differences in the frequency of losses and gains. Inactivation of both alleles of PRKAR1A by “two hits” observed in almost all cases underscores the central role of PRKAR1A in the pathogenesis of this neoplasm. © 2015 Wiley Periodicals, Inc. 相似文献
35.
Fatih Ula? ümit Dogan O?uz Dikba? Serdal ?elebi Asena Kele? 《Indian journal of ophthalmology》2015,63(3):244-249
Purpose:
The effect of hypothyroidism on the choroidal thickness (CT) was investigated in patients with subclinical hypothyroidism and overt hypothyroidism, and biochemically and clinically euthyroid patients receiving levothyroxine treatment. The patients were compared with healthy subjects.Materials and Methods:
One eye of 71 hypothyroid and 22 healthy subjects between 20 and 40 years of age were included in this study. CT measurements were taken at the fovea and at 2 points that were 1500 μm nasal and temporal to the fovea using spectral-domain optical coherence tomography. Independent sample t-test''s and was used for statistical analysis of the data.Results:
The CT was significantly thicker in hypothyroid patients compared to healthy subjects (P values were 0.013 for subfoveal, 0.015 for temporal and 0.020 for nasal segments). The intraocular pressure (IOP) and body mass index (BMI) were also significantly higher in hypothyroid patients (P values were 0.021 and 0.003, respectively). There was not a statistically significant difference in the BMI and IOP measurements between healthy subjects and euthyroid patients (P > 0.05). However, there was a statistically significant difference in the subfoveal, temporal and nasal CT measurements between healthy subjects and euthyroid patients (P values were 0.006, 0.031 and 0.013, respectively).Conclusions:
All subgroups of hypothyroid patients had thicker CT compared to healthy subjects. Euthyroid patients receiving levothyroxine treatment had lower IOP, BMI levels, and serum lipid levels than patients with subclinical hypothyroidism and overt hypothyroidism. 相似文献36.
Left main coronary artery aneurysm is rare finding at coronary angiography. We report a case of a large left main coronary artery aneurysm in a 59-year-old male who had cardiac catheterization for effort angina and inducible myocardial ischemia. 相似文献
37.
38.
39.
Does patient education increase antimuscarinic treatment persistence in overactive bladder syndrome?
下载免费PDF全文
![点击此处可从《International Journal of Urological Nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Tulin Yildiz RN PhD Cenk M Yazici MD Cagri Dogan MD Muzeyyen Cetintas RN Arzu Malak RN 《International Journal of Urological Nursing》2015,9(2):84-91
Overactive bladder syndrome (OAB) is a chronic condition that requires long‐term management. Patient education may have role in decreasing the unfavourable effects of long‐term treatment of OAB. The aim of the study was to evaluate the effect of detailed patient education on the patients' persistence with antimuscarinic treatment for OAB. A total of 140 patients with the diagnosis of OAB were included in this study. Patients were randomly divided into two groups. Patients in Group 1 were given information by the same urology doctor about the disease and treatment. Patients in Group 2 were given information by a urology nurse. Patients were recalled in the first, third and sixth months of treatment. The treatment persistency was evaluated in the whole study population and between the groups. The persistency rates of the whole group were 88·6% in the first month, 65·7% in the third month and 45·7% in the sixth month. At the end of the sixth month, 42·8% of males and 47·1% of females were taking antimuscarinics (p = 0·580). The persistence rate of Groups 1 and 2 were 82·8 and 94·3% at the first month. (p = 0·034). It decreased to 31·4% in the first and 60% in the second group at the sixth month (p = 0·001). The persistence rate of antimuscarinic treatment is low. Patient education is simple and effective way of increasing persistence. Clinicians must pay attention to inform their patients about the disease and possible side effects of treatment. An educated health provider may be very helpful in educating patients for OAB. 相似文献
40.
Hechtman Jaclyn Frances DeMatteo Ronald Nafa Khedoudja Chi Ping Arcila Maria E. Dogan Snjezana Oultache Alifya Chen Wen Hameed Meera 《Annals of surgical oncology》2015,22(8):2633-2639
Annals of Surgical Oncology - The incidence of other primary neoplasms in gastrointestinal stromal tumor (GIST) patients is relatively high. Our aim was to better characterize the clinicopathologic... 相似文献