Tagesperiodik der Rectaltemperatur sowie der Ausscheidung von Elektrolyten,Katecholaminmetaboliten und 17-Hydroxycorticosteroiden mit dem Harn beim Menschen mit und ohne Lichtzeitgeber

Zusammenfassung In einer 2mal 4 Tage dauernden Versuchsreihe wurden an 6 männlichen Versuchspersonen in 3stündigen Abständen die Urinmenge und die Harnausscheidung von Natrium, Kalium, Calcium, Dopamin, freien Gesamtkatecholaminen, Vanillinmandelsäure und 17-Hydroxycorticosteroiden, ferner tagsüber die motorische Aktivität und, kontinuierlich, die Rectaltemperatur gemessen. In beiden Versuchsabschnitten herrschte strenge Versuchsroutine mit festgesetzten Schlafzeiten. Im ersten Versuchsabschnitt kam dazu ein mit dem Wach-Schlaf-Cyclus phasengleicher Licht-Dunkel-Wechsel (LD), im zweiten Versuchsabschnitt herrschte für 96 Std Dunkelheit (DD). Die im LD beobachteten tagesrhythmischen Schwankungen bestanden im DD mit statistisch unveränderter Lage der Extremwerte zum Schlaf-Wach-Cyclus fort. Demnach war ein Licht-Dunkel-Wechsel für die Ausprägung und für die Synchronisation der Tagesperiodik der genannten Funktionen unter den Bedingungen dieses Versuchs nicht notwendig; soziale Zeitgeber wie Versuchsroutine und Schlaf-Wach-Cyclus reichten dazu aus. Die motorische Aktivität sowie Gleichwert und Schwingungsbreite der Calcium-Tageskurven waren im DD signifikant niedriger als im LD. Darüber hinaus zeigten sich Tendenzen zur Abnahme von Gleichwert und Schwingungsbreite bei den übrigen Funktionen — mit Ausnahme der 17-OHCS und der Rectaltemperatur, die im DD zu höheren Schwingungsbreiten tendierten.Stipendiat der Alexander von Humboldt-Stiftung.     

MILK SENSITIVITY IN DERMATITIS HERPETIFORMIS

SUMMARY.– A case of dermatitis herpetiformis elicited by the intake of milk is described. A woman aged 30 had suffered from colic, loose stools and fatigue for 3 years. Investigation revealed a severe atrophy of the intestinal mucosa, increased faecal fat excretion, and impaired xylose absorption. On a glutenfree and almost milk-free diet the malabsorption improved, but it recurred during a period with increased milk intake; at the same time dermatitis herpetiformis developed. Following renewed milk elimination the dermatitis disappeared. On repeated provocation and elimination of milk the dermatitis herpetiformis reappeared and disappeared. During milk intake the gamma-G, gamma-A and gamma-M-globulin increased and, when milk was eliminated, they decreased. It is suggested, that in this patient the ingestion of milk provided an antigenic stimulus which was in some way concerned with the development of the skin lesions.     

Sclerosing lymphangitis of the penis: a lymphangiofibrosis thrombotica occlusiva*

Three patients with so-called non-venereal sclerosing lymphangitis of the penis are presented. Light and electron microscopy of one case revealed a lymphatic collecting vessel with a fibrin thrombus in the process of recanalization and vessel wall fibrosis due to hyperplasia of smooth muscle cells and fibroblasts. The term ‘lymphangiofibrosis thrombotica occlusiva’ is proposed. Lymph stasis is suggested as a provoking factor for the dilatation and clinically striking firm thickening of the affected collecting vessel. No microorganisms were recognized. Within the fibrin thrombus, sprouts of endothelial cells showed intracellular vacuoles, probably indicating the first identifiable step in lymph capillary lumen formation. Signs of collagen remodelling were encountered in the thickened vessel wall.     

Hepatic arterial flow distribution with hepatic neoplasms: significance in infusion chemotherapy

Hepatic artery radionuclide flow studies and hepatic angiography in eight patients with various hepatic neoplasms were evaluated to determine the patterns of arterial flow distribution in the presence of portal vein occlusion. Increased hepatic arterial blood flow to the lobe or segment supplied by the occluded portal vein was observed in all patients. This phenomenon must be taken into account when positioning catheters for hepatic artery infusion chemotherapy; while it may improve the flow of chemotherapeutic agents to tumors located in the area of an occluded portal vein branch, it may also result in diversion of flow to the normal hepatic parenchyma away from tumors occupying the hepatic segments with patent portal venous flow. Hepatic angiography and radionuclide flow studies provide the necessary information for correct positioning of hepatic artery infusion catheters.     

Postoperative acute cholecystitis complicating urologic operations

Two cases are described of acute gangrenous cholecystitis following urologic operations. The subject is reviewed. The predominance of urologic procedures as the preceding factor for this postoperative complication is pointed out. The possible causes, the presenting features, the diagnosis, management, and serious prognosis are discussed. Awareness of the condition, early diagnosis, and operation are recommended. Its importance to the urologist is stressed.