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Marie Tournier Anne Bénard-Laribière Fabrice Jollant Emilie Hucteau Papa-Yatma Diop Ana Jarne-Munoz Antoine Pariente Emmanuel Oger Julien Bezin 《Acta psychiatrica Scandinavica》2023,148(3):233-241
Background
Previous studies that found an association between benzodiazepines and suicidal behaviours were confounded by indication bias.Aims
To limit this bias, a case crossover study (CCO) was conducted to estimate the risk of suicide attempt and suicide associated with benzodiazepines.Method
Patients ≥16 years, with hospitalised suicide attempt or suicide between 2013 and 2016, and at least one benzodiazepine dispensing within the 120 days before their act were selected in the nationwide French reimbursement healthcare system databases (SNDS). For each patient, frequency of benzodiazepine dispensing was compared between a risk period (days −30 to −1 before the event) and two matched reference periods (days −120 to −91, and −90 to −61).Results
A total of 111,550 individuals who attempted suicide and 12,312 suicide victims were included, of who, respectively, 77,474 and 7958 had recent psychiatric history. Benzodiazepine dispensing appeared higher in the 30-day risk period than in reference ones. The comparison yielded adjusted odds ratios of 1.74 for hospitalised suicide attempt (95% confidence interval 1.69–1.78) and 1.45 for suicide (1.34–1.57) in individuals with recent psychiatric history, and of 2.77 (2.69–2.86) and 1.80 (1.65–1.97) for individuals without.Conclusion
This nationwide study supports an association between recent benzodiazepine use and both suicide attempt and suicide. These results strengthen the need for screening for suicidal risk carefully before initiation and during treatment when prescribing benzodiazepines. Registration No. EUPAS48070 ( http://www.ENCEPP.eu ). 相似文献106.
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R Diouf E Diop I C Ndiaye A Tall A A Kasse L S Diop 《Revue de laryngologie - otologie - rhinologie》1991,112(5):423-427
Cervico-facial carcinology is currently one of the major concerns of oto-rhino-laryngologists. The authors have chosen laryngeal cancers to determine the limits of the practice of such cervico-facial carcinology in the topics. Over a 10-year period, 61 patients with a suspected malignant laryngeal disease were examined at the E.N.T. Clinic of the University Hospital in Dakar. Histological confirmation was found in only 38 patients, and a curative treatment was undertaken with 27 patients. No significant differentiation could be found from the results as far as sex, age and histology were concerned. On the other hand, the TNM breakdown of our 36 carcinomas revealed that in 78% of the cases large tumours (T3, T4) were involved. In the vast majority of these cases (18/27), treatment was purely surgical, with a total laryngectomy in 90% of the cases. Pharyngostomas accounted for the majority of the early postoperative complications (6/14). Over 10 years of practice, 70% of our patients have died or have been lost from sight. These poor results are due to numerous factors, including late consultation, the lack of specialists and the insufficiency of technical facilities. To improve results, the authors recommended the setting-up of proper cancer institutes. 相似文献
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Ndiaye A Diop M Ndoye JM Konaté I Ndiaye AI Mané L Nazarian S Dia A 《Surgical and radiologic anatomy : SRA》2007,29(8):675-681
Surgical access to the inguinal region, notably during hernia repairs, exposes the ilioinguinal nerve to the risk of damage
at the origin of the neuralgia. The incidence of these post-operative neuropathies and their medicolegal consequences justify
this study about the anatomical variations of the ilioinguinal nerve. With the aim of preventing its damage during repairs
of groin hernias and identifying the factors of onset of chronic spontaneous neuropathy of the ilioinguinal nerve, we dissected
100 inguinal regions of 51 fresh adult corpses. The nerve was absent in seven cases and double in one case. Out of the 94
ilioinguinal nerves observed, we analyzed the path in relation to the inguinal ligament and the connections with the walls
of the inguinal canal and its content. The ilioinguinal nerve travels along the superficial surface of the internal oblique
muscle, passing on average 1.015 cm from the inguinal ligament. In one case, the fibers of the internal oblique muscle spanned
it in several places. The nerve was antero-funicular in 78.72% of cases and perforated the fascia of the external oblique
in 28.72% of cases. The terminal division took place in the inguinal canal in 86% of cases, with terminal branches that sometimes
perforated the fascia of the external oblique. These results enabled us to better understand the etiopathogenic aspects of
certain neuropathies of the groin and to propose techniques useful for the protection of the nerve during repairs of groin
hernias. 相似文献