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81.
Themos Grigoriadis Stavros Athanasiou George Giannoulis Sylvia-Christina Mylona Dionysia Lourantou Aris Antsaklis 《International urogynecology journal》2013,24(12):2131-2144
Introduction and hypothesis
The aim of this study was the cross-cultural adaptation, validation, and psychometric evaluation in the Greek language of two self-reported instruments used for patients with pelvic floor disorders (PFDs): the Pelvic Floor Distress Inventory (PFDI-20) and the Pelvic Floor Impact Questionnaire (PFIQ-7).Methods
For the cross-cultural adaptation, a multistep forward–back translation protocol was utilized. Evaluation of the psychometric properties of the questionnaires involved the assessment of validity, stability, internal consistency, and responsiveness. Validity, stability, and internal consistency were evaluated in women presenting with PFDs (group A), whereas responsiveness was assessed in women undergoing pelvic floor surgery (group B).Results
A total of 100 women presenting with PFDs were included in Group A. A near excellent content/face validity was confirmed as assessed by the missing values criterion (0–5 %). Stability, as assessed by the intraclass correlation coefficient, showed almost perfect agreement with a mean ICC of 0.850 (PFDI-20) and 0.840 (PFIQ-7). Internal consistency was found to be high for both questionnaires (Cronbach’s alpha?>?0.8). Finally, 85 women underwent pelvic floor repair surgery and were included for the assessment of responsiveness (group B). Good to excellent responsiveness was found for the prolapse and urinary subscales of the questionnaires. However, poor responsiveness was found for the colorectal–anal scale of the PFDI-20, whereas the colorectal–anal scale of the PFIQ-7 proved to be nonresponsive to change.Conclusions
The Greek versions of PFDI-20 and PFIQ-7 were found to be comprehensible, valid, reliable, and responsive to use with patients complaining of PFDs. 相似文献82.
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84.
Vassiliou V Kalogeropoulou C Giannopoulou E Leotsinidis M Tsota I Kardamakis D 《Clinical & experimental metastasis》2007,24(3):169-178
Purpose To investigate the therapeutic response of patients with different types of bone metastases treated with combined radiotherapy
and bisphosphonates.
Patients and methods By using computed tomography 52 patients were grouped into groups of lytic, mixed and sclerotic bone lesions. All patients
were treated with concomitant radiotherapy and ibandronate (10 monthly cycles) and underwent clinical and radiological evaluations
prior to therapy and at 3, 6 and 10 months of follow up.
Results At baseline there were statistically significant differences between the three groups for all the evaluated parameters. From
3 months onwards differences were leveled out. Statistically significant improvements were noted at all time points of evaluation
for all groups in parameters such as pain (0–10), quality of life (QOL-physical functioning, 0–100) and Karnofsky performance
status (KPS). The average pain score for the lytic group was reduced from 8.1 to 1.5 points at 3 months. The corresponding
reductions for the mixed and sclerotic groups were from 6.2 to 0.5 and from 4.4 to 0.3 points respectively. Complete pain
responses were >76.4% at all time points for all groups. Opioid consumption was also markedly reduced. Overall, the highest
clinical response was noted for the lytic group, even though the mean values of pain, QOL and KPS were worse than those of
the two other groups at all time points (apart from pain score at 10 months). The percentage of patients of the lytic group
experiencing a complete pain response was the least of the three groups during follow up. At 10 months bone density was almost
tripled for the lytic and almost doubled for the mixed group.
Conclusions Even though the therapeutic outcome for the three groups was similar, the degree of clinical response and reossification differed. 相似文献
85.
Spiropoulos K Trakada G Kalamboka D Kalogeropoulou C Petsas T Efremidis G Tsiamita M Trakada A Dimopoulos I 《Lung》2003,181(4):169-181
High-resolution computed tomography (HRCT) is a useful method for quantifying the extent of emphysema. Few reports have mentioned the relationships between HRCT scans and pulmonary function tests in chronic obstructive pulmonary disease (COPD). For diagnosis, COPD requires chronic airflow limitation and emphysema and/or chronic bronchitis. We examined 20 who were previous smokers with middle to moderate COPD. All were normocapnic with mean arterial oxygen pressure (PaO2) 77,52 ± 16,789 mmHg. Forced spirometry, somatic plethysmography and cardiopulmonary exercise test were performed in each patient. HRCT was performed in both full inspiration and full expiration at three levels through the upper (at the aortic arch), lower (2 cm above the diaphragm), and middle lung (midpoint between upper and lower) levels. During expiration all pulmonary function parameters correlated with the HRCT grade in the middle right and left part of the lungs. The middle right part of the lung during expiration correlated statistically significant with MVV (r = –0.681, p =0.001), forced vital capacity (FVC) (r = –0.477, p = 0.027), forced expiratory volume in 1 sec (FEV1) (r = –0.632, p = 0.002), resistance (r = 0.674, p = 0.001), residual volume (RV) (r = 0.733, p = 0.001), total lung capacity (TLC) (r = 0.696, p = 0.001), functional residual capacity (FRC) (r = 0.752, p =0.001) and peak oxygen consumption during exercise (VO2) (r = –0.493, p = 0.023). The middle left part of the lung during expiration correlated statistically significant with MVV (r = –0.673, p = 0.001), FVC (r = –0.493, p = 0.027), FEV1 (r = –0.629, p = 0.003), resistance (r = 0.593, p = 0.005), RV (r = 0.601, p = 0.005), TLC (r = 0.546, p = 0.012), FRC (r = 0.594, p = 0.006) and peak VO2 (r = –0.525, p = 0.015). Forced expiratory volume in 1 sec (FEV1), which is a well-established measure of airflow obstruction, correlated with the HRCT grade (1) in the middle left part of the lung during inspiration (r = –0.468, p = 0.035) and during expiration (r = – 0.629, p = 0.003) (2) in the lower right lung during inspiration (r = –0.567, p = 0.007) and during expiration (r = –0.558, p = 0.008) (3) in the lower left lung during inspiration (r = –0.542, p = 0.011) and during expiration (r = –0.558, p = 0.008) (4) in the upper right lung during expiration (r = –0.469, p = 0.037) (5) in the upper left lung during expiration (r = –0.463, p = 0.035) and (6) in the middle right lung during expiration (r = –0.632, p = 0.002). According to our results HRCT was a valuable tool for evaluating the severity of COPD — especially the middle right and left part of the lungs, during expiration — and correlated well with pulmonary function tests. 相似文献
86.
Christina Liava Emmanouil Sinakos Elissavet Papadopoulou Lamprini Giannakopoulou Stamatia Potsi Anestis Moumtzouoglou Anthi Chatziioannou Loukas Stergioulas Lydia Kalogeropoulou Ioannis Dedes Evangelos Akriviadis Danai Chourmouzi 《World journal of gastroenterology : WJG》2022,28(32):4540-4556
Hepatocellular carcinoma (HCC) is the sixth most common cancer. The main risk factors associated with HCC development include hepatitis B virus, hepatitis C virus, alcohol consumption, aflatoxin B1, and nonalcoholic fatty liver disease. However, hepatocarcinogenesis is a complex multistep process. Various factors lead to hepatocyte malignant transformation and HCC development. Diagnosis and surveillance of HCC can be made with the use of liver ultrasound (US) every 6 mo. However, the sensitivity of this imaging method to detect HCC in a cirrhotic liver is limited, due to the abnormal liver parenchyma. Computed tomography (CT) and magnetic resonance imaging (MRI) are considered to be most useful tools for at-risk patients or patients with inadequate US. Liver biopsy is still used for diagnosis and prognosis of HCC in specific nodules that cannot be definitely characterized as HCC by imaging. Recently the American College of Radiology designed the Liver Imaging Reporting and Data System (LI-RADS), which is a comprehensive system for standardized interpretation of CT and MRI liver examinations that was first proposed in 2011. In 2018, it was integrated into the American Association for the Study of Liver Diseases guidance statement for HCC. LI-RADS is designed to ensure high sensitivity, precise categorization, and high positive predictive value for the diagnosis of HCC and is applied to “high-risk populations” according to specific criteria. Most importantly LI-RADS criteria achieved international collaboration and consensus among liver experts around the world on the best practices for caring for patients with or at risk for HCC. 相似文献
87.
Stella Fragkiadaki Dionysia Kontaxopoulou Ion N. Beratis Nikolaos Andronas Alexandra Economou George Yannis 《Journal of clinical and experimental neuropsychology》2016,38(10):1144-1157
Introduction: Self-estimation of performance implies the ability to understand one’s own performance with relatively objective terms. Up to date, few studies have addressed this topic in mild cognitive impairment (MCI) patients. The aim of the present study was to compare objective measures of performance with subjective perception of specific performance on cognitive tests and investigate differences in assessment between MCI patients and healthy elderly. Method: Thirty-five participants diagnosed with MCI (women = 16, men = 19, mean age = 65.09 years ±SD = 7.81, mean education = 12.83 years ±SD = 4.32) and 35 control subjects similar in terms of age and education (women = 20, men = 15, mean age = 62.46 years ± SD = 9.35, mean education = 14.26 ± SD = 2.84) were examined with an extended battery of neuropsychological tests. After every test they were asked to self-evaluate their performance by comparing it to what they considered as average for people of their age and educational level. This self-evaluation was reported on a scale ranging from –100 to +100. Results: Significant differences were found in the self-assessment patterns of the two groups in memory measures of verbal and visual delayed recall, visuospatial perception, and tests of attention. MCI patients overestimated their performance on every cognitive domain while control participants underestimated their performance on measures of verbal memory. Conclusions: The present results indicate that accuracy of self-report is not uniform across groups and functional areas. The discrepancies in the MCI patients indicate unawareness of their memory deficits, which is contradictory to subjective memory complaints as being an important component for clinical diagnosis. 相似文献
88.
89.
90.
Petros Zabakis Dimitrios M Kardamakis Dimitrios Siablis Christina Kalogeropoulou Dimitrios Karnabatidis Georgia Malatara Ioannis A Dimopoulos 《Radiotherapy and oncology》2005,74(1):11-16
BACKGROUND AND PURPOSE: To evaluate the feasibility and efficacy of external beam irradiation (EBI) for the prevention of re-stenosis due to neointimal hyperplasia, after percutaneous transluminal angioplasty (PTA) and stent placement of the superficial femoral artery. PATIENTS AND METHODS: A total of 60 patients with the diagnosis of superficial femoral artery stenoses or occlusions due to peripheral arterial obstructive disease underwent PTA and implantation of a self-expandable stent at their superficial femoral artery. After the procedure, patients were randomised and 30 of them received EBI (6 MV photons, total dose 24 Gy in six fractions in 2 weeks), while the rest 30 received no radiation therapy. RESULTS: EBI was technically feasible in all patients, without serious radiation related side effects. Overall, a statistically significant difference was observed in stenosis categories between the two groups at 6 months follow-up (P=0.04). More specifically, significantly more patients in the control group presented with stenosis greater or equal than 70% [EBI group 30% (9/30); control group 66.7% (20/30); P=0.009]. This difference in the percentage of re-stenosis had as a consequence significantly lower re-intervention rates among the patients of the irradiated group [17% (5/30) versus 47% (14/30); P=0.025] during the 6 months follow-up period. We also observed that the irradiated patients had re-stenosis at the stent ends, while the non-irradiated had re-stenosis at the stent ends and the lumen. Three of the irradiated patients, who discontinued the anti-platelet treatment, have shown thrombosis of the irradiated artery during the first month from the completion of the treatment. CONCLUSIONS: It is our belief that EBI is a feasible, safe and effective method for the prevention of neointimal hyperplasia at the superficial femoral artery. Further studies are deemed necessary to optimise the radiotherapy schedule. 相似文献