全文获取类型
收费全文 | 643篇 |
免费 | 48篇 |
国内免费 | 1篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 23篇 |
妇产科学 | 63篇 |
基础医学 | 46篇 |
口腔科学 | 5篇 |
临床医学 | 45篇 |
内科学 | 121篇 |
皮肤病学 | 1篇 |
神经病学 | 44篇 |
特种医学 | 51篇 |
外科学 | 129篇 |
综合类 | 11篇 |
预防医学 | 33篇 |
眼科学 | 9篇 |
药学 | 55篇 |
肿瘤学 | 53篇 |
出版年
2021年 | 12篇 |
2018年 | 10篇 |
2017年 | 5篇 |
2016年 | 13篇 |
2015年 | 12篇 |
2014年 | 20篇 |
2013年 | 18篇 |
2012年 | 29篇 |
2011年 | 42篇 |
2010年 | 15篇 |
2009年 | 21篇 |
2008年 | 31篇 |
2007年 | 30篇 |
2006年 | 31篇 |
2005年 | 26篇 |
2004年 | 27篇 |
2003年 | 17篇 |
2002年 | 14篇 |
2001年 | 6篇 |
2000年 | 7篇 |
1999年 | 13篇 |
1998年 | 5篇 |
1997年 | 7篇 |
1995年 | 5篇 |
1994年 | 5篇 |
1992年 | 10篇 |
1991年 | 11篇 |
1990年 | 10篇 |
1989年 | 8篇 |
1988年 | 11篇 |
1987年 | 5篇 |
1985年 | 18篇 |
1983年 | 9篇 |
1982年 | 5篇 |
1980年 | 6篇 |
1979年 | 12篇 |
1978年 | 10篇 |
1977年 | 7篇 |
1976年 | 11篇 |
1975年 | 9篇 |
1974年 | 16篇 |
1973年 | 8篇 |
1972年 | 10篇 |
1971年 | 11篇 |
1970年 | 5篇 |
1969年 | 11篇 |
1968年 | 9篇 |
1967年 | 7篇 |
1966年 | 5篇 |
1962年 | 5篇 |
排序方式: 共有692条查询结果,搜索用时 15 毫秒
81.
82.
Improved survival of primary cadaveric renal allografts in blacks with quadruple immunosuppression. 总被引:4,自引:0,他引:4
R S Gaston S L Hudson M H Deierhoi W H Barber D A Laskow B A Julian J J Curtis B O Barger T W Shroyer A G Diethelm 《Transplantation》1992,53(1):103-109
Black recipients of cadaveric kidneys have been shown to have a lower rate of allograft survival than whites. Data were reviewed from 642 primary cadaveric transplants: results in 276 patients (163 white and 113 black) (group 1) who had received triple therapy (azathioprine-CsA-prednisone, 1985-87) were compared with those in 366 patients (180 white and 186 black) (group 2) receiving quadruple immunosuppression (MALG-azathioprine-CsA-prednisone, 1987-90). Blacks in group 2 had better patient (97% vs. 91%, P = 0.03) and graft (77% vs. 55%, P = 0.0002) survival at 1 year than in group 1. There was no difference in these parameters among whites in either group. Racial differences in graft survival noted in group 1 disappeared in group 2. While HLA BDR matching improved in group 2 patients (P = 0.0001), whites received better matched kidneys than blacks in both groups (P = 0.001). HLA matching was associated with improved graft survival only in white recipients of 4 BDR-matched kidneys. In group 1, more blacks than whites had at least one episode of acute rejection (76% vs. 57%, P = 0.001); blacks also lost more grafts to acute and chronic rejection. In group 2, there were no racial differences in the number of rejection episodes or immunologic graft losses. Of 14 potential variables examined by parametric analysis, only quadruple therapy significantly reduced risk of graft loss in blacks. Quadruple immunosuppression improved primary cadaveric renal allograft survival in black recipients, abrogating previously noted racial differences. 相似文献
83.
S M Riley E H Blackstone W A Sterling A G Diethelm 《Surgery, gynecology & obstetrics》1978,146(2):203-208
This noninvasive echocardiographic study of cardiac performance in 27 patients with chronic renal failure and vascular access documented the magnitude of forward cardiac output to be 65 per cent of the observed index. Hemodialysis resulted in acute hemodynamic changes, including an average fall in the cardiac index of 57 per cent, presumably because of a 40 per cent decrease in left ventricular filling volume. In patients in whom the vascular access had functioned longest, a time related cardiac decompensation is suggested by a cardiac index of significantly less than normal, p, 0.0013, with occlusion. Ventricular function was suboptimal three months post-transplant, as reflected by a continued low cardiac index and depressed ejection fraction, although the general reduction in cardiac index and diastolic volume on postoperative day 7 was of the magnitude expected from arteriovenous access occlusion. 相似文献
84.
85.
86.
Successful renal transplantation in hyperoxaluria 总被引:1,自引:0,他引:1
J M Morgan M W Hartley A C Miller A G Diethelm 《Archives of surgery (Chicago, Ill. : 1960)》1974,109(3):430-433
87.
Presence of apoptotic and nonapoptotic disseminated tumor cells reflects the response to neoadjuvant systemic therapy in breast cancer
下载免费PDF全文
![点击此处可从《Breast cancer research : BCR》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Fehm T Becker S Becker-Pergola G Sotlar K Gebauer G Dürr-Störzer S Neubauer H Wallwiener D Solomayer EF 《Breast cancer research : BCR》2006,8(5):R60-7
Introduction
Neoadjuvant systemic therapy (NST) is an established strategy to reduce tumor size in breast cancer patients prior to breast-conserving therapy. The effect of NST on tumor cell dissemination in these patients is not known. The aim of this study was to investigate the incidence of disseminated tumor cells (DTC), including apoptotic DTC, in breast cancer patients after NST, and to investigate the correlation of DTC status with therapy response. 相似文献88.
89.
Kinetic Studies on Activated Sulfones The decomposition rates and equilibria of activated sulfones are determined by pH-stat titrations of the sulfinic acids liberated during the decomposition reactions. The kinetic data are correlated with the Hammett σ constants. 相似文献
90.
J. Annus T. Brat Mr P. Diethelm R.H. Gray A. Lopes J. Newton E. Pizarro P.J. Rowe T. Scholz E.W. Wilson 《Contraception》1980,22(1):9-18
A multinational comparative trial of three IUDs (Copper 7, Lippes loop size D and the Postpartum T) randomly inserted immediately following delivery of the placenta was conducted in six centres. A total of 841 women entered the study. As the predetermined termination indices for expulsions were exceeded at six months the trial was prematurely closed. An excess of expulsions during the first 48 hours following insertion was observed for the Lippes loop compared to the other devices. At six months the expulsion rate for the Lippes loop was significantly higher than that for the Copper 7. In addition, the discontinuation rate for the Lippes loop at 12 months was significantly higher than that for the Copper 7. There were no significant differences in either the expulsion rates or the discontinuation rate at six or twelve months between the postpartum T and the other devices. At 12 months the pregnancy rates with all three devices was high; there were no ectopic pregnancies. Considerable between-centre differences were observed, particularly for expulsion rates. Possible reasons for this are discussed and future research lines are suggested. 相似文献