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Armin Dick Wolfgang Kromen Eberhard Jüngling Stephanie Grosskortenhaus Helmut Kammerrmeier Dierk Vorwerk Rolf W. Günther 《Cardiovascular and interventional radiology》1999,22(5):389-393
Purpose: To quantify horseradish peroxidase (HRP) delivery into the arterial wall, as a model of local drug delivery, and to compare
two different percutaneous delivery balloons.
Methods: Perforated and hydrophilic hydrogel-coated balloon catheters were used to deliver HRP in aqueous solution into the wall of
porcine iliac arteries in vivo. HRP solutions of 1 mg/ml were used together with both perforated and hydrophilic hydrogel-coated
balloon catheters and 40 mg/ml HRP solutions were used with the hydrogel-coated balloon only. The amount of HRP deposited
in the arterial wall was then determined photospectrometrically.
Results: Using the 1 mg/ml HRP solution, the hydrogel-coated balloon absorbed 0.047 mg HRP into the coating. Treatment with this balloon
resulted in a mean vessel wall concentration of 7.4 μg HRP/g tissue ± 93% (standard deviation) (n = 7). Treatment with the hydrogel-coated balloon that had absorbed 1.88 mg HRP into the coating (using the 40 mg/ml HRP solution)
led to a mean vessel wall concentration of 69.5 μg HRP/g tissue ± 74% (n = 7). Treatment with the perforated balloon using 1 mg/ml aqueous HRP solution led to a mean vessel wall concentration of 174 μg/g
± 81% (n = 7). Differences between the hydrogel-coated and perforated balloons (1 mg/g solutions of HRP) and between hydrogel-coated balloons
(0.047 mg vs 1.88 mg absorbed into the balloon coating) were significant (p < 0.05; two-sided Wilcoxon test).
Conclusions: The use of a perforated balloon catheter allowed the delivery of a higher total amount of HRP compared with the hydrogel-coated
balloon, but at the cost of a higher systemic HRP application. To deliver 174 μg HRP per gram of vessel wall with the perforated
balloon, 6.5 ± 1.5 mg HRP were lost into the arterial blood (delivery efficiency range = 0.2%–0.3%). With 0.047 mg HRP loaded
into the coating of the hydrogel balloon, 7.4 μg HRP could be applied to 1 g of vessel wall (delivery efficiency 1.7%), and
with 1.88 mg HRP loaded into the coating of the hydrogel balloon, 69.5 μg HRP could be applied per gram of vessel wall (delivery
efficiency 0.6%). 相似文献
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Pulmonary vein (PV) isolation is an effective treatment option for symptomatic atrial fibrillation. PV stenosis is a well-recognized complication of radiofrequency energy application but has not been observed following cryoballoon ablation. Here, we report a case of asymptomatic PV stenosis associated with cryoballoon PV isolation, illustrating a risk that should be considered when applying this technique. 相似文献
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Achieving successful communication in transcultural contexts means integrating emotional communication patterns into a global context. Professional, rational communication is characteristic of the cultural dimension, and emotions are characteristic of the direct, interpersonal dimension of human existence. Humans strive to achieve coherence in all dimensions of their lives; this goal is in the end the most essential aspect of psychophysical self-regulation. A major role in integrating emotional needs and cultural features in global coherence is played by the attractor 'global affinity'. The transitions from emotional coherence to cultural coherence, and likewise from cultural coherence to global coherence, can cause considerable insecurity as well as psychological problems, which previously went by the name 'adjustment disorders'. However, instead of pathologizing these processes, we should understand them in a salutogenic sense as challenges important for both individual and collective development. The development of more coherence is regulated by the neuropsychological approach and avoidance system. This system can be consciously fostered by directing our attention to the commonalities of all human beings. Such a global salutogenic orientation furthers both communication and creativity in teamwork. This article introduces a consequent salutogenic and evolutionary systemic view of transcultural communication and demonstrates its effectiveness in a number of case examples. 相似文献
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Dierk Vorwerk Ziv J. Haskal Yasuaki Arai 《Cardiovascular and interventional radiology》2010,33(6):1073-1078
Editorial
Editor’s Recognition Award for Distinction in Reviewing 2010 相似文献59.
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